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Retinal neovascularization induced by mutant vldlr gene inhibited in an inherited retinitis pigmentosa mouse model:an in-vivo study

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International Journal of Ophthalmology(English edition) 2021年第7期14卷 990-997页

作者： Wei-Ming Yan Pan Long Mei-Zhu Chen Dong-Yu Wei Jian-Cong Wang Zuo-Ming Zhang Lei Zhang Tao Chen Department of Ophthalmology the 900^(th)Hospital of Joint Logistic Support Forceo of PLA(Clinical Medical College of Fujian Medical UniversityDongfang Hopsital Affiliated to Xiamen University)Fuzhou 350025Fujian ProvinceChina Center of Clinical Aerospace Medicine Air Force Medical UniversityXi’an 710032Shaanxi ProvinceChina Department of Ophthalmology the West General Hospital of Chinese PLAChengdu 610083Sichuan ProvinceChina BeiJing HealthOLight Technology Co. Ltd.Beijing 10010China Shaanxi Eye Hospital Xi’an People’s Hospital(Xi’an Fourth Hospital)Affiliated Guangren HospitalSchool of MedicineXi’an Jiaotong UniversityXi’an 710004Shaanxi ProvinceChina

AIM:To explore whether the retinal neovascularization(NV)in a genetic mutant mice model could be ameliorated in an inherited retinitis pigmentosa(RP)mouse,which would help to elucidate the possible mechanism and prevention of retinal NV diseases in ***:The vldlr^(-/-)mice,the genetic mutant mouse model of retinal NV caused by the homozygous mutation of vldlr gene,with the rd1 mice,the inherited RP mouse caused by homozygous mutation of Pde6b gene were *** of the above two mice led to the birth of the F1 hybrids,further inbreeding of which gave birth to the F2 *** ocular genotypes and phenotypes of the mice from all generations were examined,with the F2 offspring grouped according to the ***:The rd1 mice exhibited the RP phenotype of outer retinal degeneration and loss of retinal *** vldlr^(-/-)mice exhibited the phenotype of retinal NV obviously shown by the fundus fluorescein *** F1 hydrides,with the heterozygote genotype,exhibited no phenotypes of RP or retinal *** F2 offspring with homozygous genotypes were grouped into four *** were the F2-Ⅰmice with the wild-type Pde6b and vldlr genes(Pde6b~(+/+)-vldlr~(+/+)),which had normal ocular phenotypes;the F2-Ⅱmice with homozygous mutant vldlr gene(Pde6b~(+/+)-vldlr^(-/-)),which exhibited the retinal NV phenotype;the F2-Ⅲmice with homozygous mutant Pde6b gene(Pde6b^(-/-)-vldlr~(+/+)),which exhibited the RP ***,the F2-Ⅳmice with homozygous mutant vldlr and Pde6b gene(Pde6b^(-/-)-vldlr^(-/-))showed only the RP phenotype,without the signs of retinal ***:The retinal NV can be inhibited by the RP phenotype,which implies the role of a hyperoxic state in treating retinal NV diseases.

关键词： retinitis pigmentosa retinal neovascularization Pde6b gene vldlr gene photoreceptor

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