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vitamin k alleviates bone calcium loss caused by Salmonella Enteritidis through carboxylation of osteocalcin

Journal of Animal Science and Biotechnology 2021年第4期12卷 1572-1581页

作者： Yaojun Liu Rainer Mosenthin Lihong Zhao Jianyun Zhang Cheng Ji Qiugang Ma State key Laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China Institute of Animal Science University of Hohenheim70593 StuttgartGermany

Background:The present study aimed at evaluating the effect of vitamin k(Vk)supplementation on bone health of laying hens challenged by Salmonella Enteritidis.Methods:A total of 8032-week-old double negative salmonella-free brown-egg laying hens were randomly assigned to 4 treatments with 20 replicates each(1 bird per replicate)according to a 2×2 factorial design with 2 dietary Vk supplementation levels[0 mg/kg(Vk0)vs 2 mg/kg Vk(Vk2)and 2 challenge treatments[Salmonella Enteritidis(SE)vs physiological saline solution(PS)].During the last 3 days of week 43 of age,birds of both Vk treatments were either orally challenged with 1.0 mL suspension of 109 cfu/mL S.Enteritidis daily or received the same volume of PS.Results:The laying rate,daily egg mass,tibia strength,CT,cOC and cOC/(cOC+ucOC)of Vk2 treatment increased(Pk0,however,the medullary area and ucOC of Vk2 treatment decreased(Pk0.Mortality,medullary area,serum Ca content of SE treatments increased(Pk levels with regard to tibia strength and serum Ca levels.At week 42,serum CT was positively correlated with cOC(R=0.99,P=0.009);at week 44,tibia strength was positively correlated with BMD(R=0.95,P=0.045),but negatively correlated with medullary area(R=−0.98,P=0.018).Conclusions:Vk(2 mg/kg)supplementation to diets of laying hens can enhance bone strength under challenge situations with Salmonella Enteritidis.Medullary area has proven to be a sensitive biomarker for bone calcium loss caused by SE infection.

关键词： Calcium Laying hen Salmonella Enteritidis vitamin k

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Relationship between Acquired Deficiency of vitamin k-dependent Clotting Factors And Hemorrhage

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2010年第3期30卷 312-317页

作者：杨锐张小平魏文宁洪梅杨焰胡豫 Institute of Hematology Union HospitalTongji Medical CollegeHuazhong University of Science and Technology key Laboratory of Biological Targeted Therapy of Hubei Province

This study examined the changes of activities of vitamin k-dependent clotting factors(VkDCF) under various pathological conditions and explored the relationship between acquired deficiency of VkDCFs and hemorrhage.Clinical data of 35 patients who were diagnosed as having acquired deficiency of VkDCF were retrospectively analyzed.Coagulation factors involved in the intrinsic and extrinsic pathways were detected in these patients and 41 control subjects.The results showed that the average activities of VkDCFs were decreased in the patients in comparison to the control subjects and significantly increased after treatment of these patients with vitamin k and blood products.Multivariate regression analysis indicated that decreased activity of VkDCF was not an independent risk factor for bleeding disorders owing to deficiency or metabolic disturbance of vitamin k.It was concluded that acquired deficiency of VkDCF occurs under a variety of pathologic conditions and is closely associated with hemorrhagic events.Administration of vitamin k and transfusion of blood products containing high concentrations of VkDCFs helps alleviate the hemorrhagic diseases.

关键词： coagulation factor deficiency hemorrhage vitamin k

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Dietary vitamin k Restriction and Effectiveness of vitamin k Antagonists Prescribed at the CNHU-HkM University Cardiology Clinic/BENIN

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Food and Nutrition Sciences 2023年第10期14卷 928-940页

作者： Clémence Germaine Metonnou Charles Jérôme Sossa Lamidhi Salami Rébécca Sabgohan Colette Azandjeme Camelle Mizehoun-Adossoda Virginie Mongbo Health Promotion Department Regional Institute of Public Health University of Abomey-Calavi Ouidah Benin Health Policy and Systems Department Regional Institute of Public Health University of Abomey-Calavi Abomey-Calavi Benin School of Nutrition-Dietetics Faculty of Health Sciences University of Abomey-Calavi Cotonou Benin

Introduction: Their efficacy in preventing thrombotic and embolic events has been proven in numerous studies, but their narrow therapeutic index requires particular vigilance, especially in terms of biology. In addition, treatment-related hemorrhagic complications are not uncommon. This study explores the influence of dietary vitamin k restriction on the efficacy of antivitamin k treatment at the University Cardiology Clinic of CNHU-HkM. Methods: Cross-sectional and descriptive study that took place from 25 April to 29 August 2019. Patients’ dietary behaviors and successive INR values were collected. Information on dietary intake was obtained by 2 non-consecutive 24-hour recalls. The effectiveness of VkA treatment was assessed by the “Time in Therapeutic Range” (TTR) of the INR. VkA treatment was considered effective for a TTR greater than 65%. Results: At the end of this study, 40 patients were surveyed. The mean age of the participants was 58.05 years ± 13.32 years, with a sex ratio of 1.35. Complete arrhythmia due to atrial fibrillation was the main indication for VkA treatment (37.50%) and fluindione was the most commonly prescribed drug (77.50%). The duration of treatment was less than or equal to 2 years in 47.5% of the subjects surveyed. Before starting treatment, 85% of patients received advice on restricting vitamin k-rich foods, and 45% of patients reported “food burnout” after a period of compliance with the restriction. The majority of respondents (97.50%) complied with the restriction on vitamin k-rich foods. All respondents had high energy intakes and a poor distribution of macronutrients, with a predominance of carbohydrates and proteins. 2.5% of respondents were on effective anti-vitamin k therapy with a TTR of over 65%. Conclusion: Restriction of vitamin k-rich foods is not conducive to effective treatment with vitamin k antagonists.

关键词： Antivitamin k Dietary Restriction vitamin k Therapeutic Efficacy

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Coagulation function in patients with pancreatic carcinoma

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Chinese Medical Journal 2009年第6期122卷 697-700页

作者： WANG Hang-yan XIU Dian-rong LI Zhi-fei WANG Gang Department of General Surgery Peking University Third Hospital Beijing 100191 China

Background The coagulation function in patients with pancreatic carcinoma is abnormal and the reason is not very clear. In this study, we retrospectively analyzed the coagulation function in patients with pancreatic carcinoma.Methods From June 2004 to December 2007, 132 patients received diagnosis and treatment in our hospital. The coagulative parameters including the prothrombin time, activated partial thromboplastin time, and fibrinogen levels were collected and studied retrospectively.Results The average fibrinogen levels in patients with pancreatic carcinoma, （476.21±142.05） mg/dl, were significantly higher than in patients with cholangiolithiasis, （403.28±126.41） mg/dl （P 〈0.05）. In patients with pancreatic carcinoma, the levels of fibrinogen in the group with jaundice were significantly higher than in patients without jaundice （P 〈0.05）. In patients who received Pancreaticoduodenectomy, Whipple＇s operation, the level of fibrinogen in the group with local invasiveness was significantly higher than in the group without invasiveness. The group with lymphatic metastasis had higher levels than the group without lymphatic metastasis （P 〈0.05）. There was no significant difference of intraoperative blood loss between patients with vitamin k, （748.27±448.51） ml, and those without vitamin k, （767.31±547.89） ml （P 〉0.05）.Conclusions The level of fibrinogen in patients with pancreatic carcinoma was elevated. The elevated fibrinogen level may be associated with invasiveness and lymphatic metastasis. Using vitamin k in perioperation management did not reduce intraoperative blood loss.

关键词： pancreatic carcinoma fibrinogen pancreatic cancer vitamin k

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维生素k穴位注射治疗严重原发性痛经的国际合作临床研究(英文)

维生素K穴位注射治疗严重原发性痛经的国际合作临床研究(英文)

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第三届江浙沪中西医结合高峰论坛

作者：王莉 Francesco Cardini Anna Laura Regalia Christine Wade Emanuela Forcella 复旦大学附属妇产科医院

目的:痛经是一种常见的妇科疾病,Vit k穴位注射是从传统中医衍生的一种针药结合治疗痛经的中西医结合新方法。本研究的目的是探讨维生素k穴位注射对不同国家和文化背景的严重痛经患者的治疗效果。方法:受试对象于痛经的第1天或第2天行Vi... 详细信息

目的:痛经是一种常见的妇科疾病,Vit k穴位注射是从传统中医衍生的一种针药结合治疗痛经的中西医结合新方法。本研究的目的是探讨维生素k穴位注射对不同国家和文化背景的严重痛经患者的治疗效果。方法:受试对象于痛经的第1天或第2天行Vit k三阴交穴位注射,双侧穴位注入4mg维生素k(中国)或5mgVit k(意大利),治疗前、治疗后及其后3个随访周期进行疼痛强度和持续时间评价,并记录卧床时间改变、日常活动受限情况、服用药物情况。结果:在中国和意大利vit k穴位注射均可显著缓解原发性痛经,二国的VAS积分在治疗后下降都非常明显(pk穴位注射是一种治疗原发性痛经有效安全的治疗方法,在随访周期中显示持续的止痛效果,且对不同种族和文化背景的人群都有效,可以推荐作为任何急症情况下严重痛经的治疗。

关键词： dysmenorrhea menstrual pain acupuncture traditional medicine Chinese vitamin k

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