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vitamin d insufficiency among Women Post-Partum in Northern Sweden—A Public Health Concern

Food and Nutrition Sciences 2017年第1期8卷 99-109页

作者： Pamela Hasslof Frida Karlsson Videhult Sven Arne Silfverdal Christina E.West Christina Stecksén-Blicks department of Odontology Pediatric DentistryUmea UniversityUmeaSweden department of Clinical Sciences PediatricsUmea UniversityUmeaSweden

Pregnancy and post-partum represent a period of susceptibility for vitamin d insufficiency. This study investigated S-25 [OH] d levels in women in northern Sweden 4 weeks post-partum and its association with selected background factors. Blood from 100 healthy women were analyzed for iron status and serum levels of S-25[OH] d using ionization-mass spectrometry (HPLC-APCI-MS). d as insufficiency and deficiency. Maternal BMI, dietary habits, fungal infections during pregnancy, and infant birth characteristics were collected using questionnaires and medical charts. 58% were vitamin d insufficient whereas 10% had deficiency. insufficiency was most common during winter (OR = 2.77;95% CI = 1.1-6.96) and women with deficiency reported lower milk consumption;11.3 ± 22.8 intakes per months vs. 34.0 ± 28.9 for those above 25 nmol/L (p °49'N. The odds of being insufficient were increased during winter whereas milk consumption was negatively associated with deficiency. The low vitamin d-levels particularly during winter is a public health concern. From a public health perspective it has to be considered whether dietary advices alone should be modified or if supplementation with vitamin d during pregnancy and the post-partum period also is needed.

关键词： vitamin d insufficiency Fungal Infection Postpartum Public Health Season

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Association between vitamin d insufficiency and the Risk for Gestational diabetes Mellitus in Pregnant Chinese Women

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Biomedical and Environmental Sciences 2012年第4期25卷 399-406页

作者： WANG Ou NIE Min HU Ying Ying ZHANG Kui LI Wei PING Fan LIU Jun Tao CHEN Li Meng XING Xiao Ping department of Endocrinology Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Sciences Key Laboratory of Endocrinology Ministry of Health Beijing 100730 China department of Obstetrics& Gynecology Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Sciences Beijing 100730 China department of Nephrology Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Sciences Beijing 100730 China

Objective To investigate the association between vitamin d deficiency and risk of gestational diabetes rnellitus （GdM） in pregnant Chinese women. Methods A nested case-control study was conducted. Clinical and biochemical data were analyzed for 200 subjects with GdM and 200 subjects with normal glucose tolerance （NGT）. Results The median （interquartile range） serum 25-hydroxyvitamin d （25OHd） levels were 22.39 （17.67, 29.38） and 25.86 （19.09, 34.88） nmol/L in the GdM and NGT groups, respectively. Rates of 25OHd deficiency or insufficiency were significantly higher in the GdM group than in the NGT group. Subjects with 25OHd levels 〈25 nmol/L had a 1.g-fold higher risk of GdM compared with subjects with higher vitamin d levels. In the GdM group, serum 25OHd was independently associated with HbAlc and insulin resistance after adjusting for confounding factors. In the NGT group, serum 25OHd was independently associated with fasting plasma glucose and systolic blood pressure after adjusting for maternal age and other confounding factors. Conclusion 2SOHd insufficiency is very common in Chinese women. Low 25OHd status may be associated with insulin resistance and act as a risk factor for GdM.

关键词： Gestational diabetes mellitus vitamin d insufficiency Chinese women

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vitamin d deficiency and insufficiency in Northeast Tennessee

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Health 2020年第9期12卷 1085-1094页

作者： Arun Joseph Kattakayam donovan Reed Sajin M. Karakattu Beth Bailey Millard Ray Lamb Paul O. Lewis dima Youssef department of Internal Medicine Norwalk Hospital Norwalk CT USA Texas Oculoplastics Consultants TOC Eye & Face Austin TX USA department of Internal Medicine Division of Pulmonary and Critical Care East Tennessee State University Johnson City TN USA department of Family Medicine East Tennessee State University Johnson City TN USA Recovery Associates Johnson City TN USA department of Pharmacy Johnson City Medical Center Johnson City TN USA department of Internal Medicine Division of Infectious Diseases East Tennessee State University Johnson City TN USA

Background: The role of vitamin d in population subgroups throughout the world continues to be a topic of interest among researchers. Current evidence demonstrates that treating vitamin d deficiency plays a significant role in improving mortality in hospitalized patients, reducing hospital length of stay, and boosting innate immune system. vitamin d levels vary with age, gender, body mass index (BMI) and geographical area. The purpose of this study is to evaluate vitamin d levels in a cohort of patients in Northeast Tennessee. Study: This institutional review board-approved, retrospective study evaluated vitamin d levels of patients obtained from Mcleod Cancer and Blood Center. vitamin d levels were collected over a 2-year period and classified as deficient (30 ng/mL). data were then stratified based on patient characteristics (age, gender, body mass index (BMI), race, seasons, and place of residence) and compounds of vitamin d (d2 and d3). Results: There were 2011 individuals included, with only 44.3% having replete levels and 21.4% with levels less than 20 ng/mL. Females with vitamin d deficiency are more likely to have levels below 20 ng/ml compared to males (18.6% vs. 23%, respectively, p = 0.003). Regarding BMI, the highest levels were reported in normal weight and overweight. With regards to age, advanced age (≥70) was associated with the highest levels and most replete patients. Winter months were associated with the lowest levels of vitamin d. Higher vitamin d levels were found in individuals over 70 years, normal weight and overweight category. Conclusion: Testing vitamin d levels in high-risk groups becomes of utmost importance in areas with longer winter months, obese and underweight patients. vitamin d levels should be routinely tested and treated in vulnerable populations.

关键词： vitamin d vitamin d deficiency vitamin d insufficiency Northeast Tennessee

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Efficacy of Hypovitaminosis d Correction in Children of the Older Age Group Residing in Moscow

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Journal of Health Science 2017年第6期5卷 271-281页

作者： Zakharova Irina Solovyova Ekaterina Klimov Leonid Vasilyeva Svetlana Tvorogova Tatyana Sugyan Narine Rakhteenko Alina Kuryaninova Victoria Pludowsky Pawel department of Pediatric FSBEI HPT "Russian Medical Academy of Postgraduate Continuing Education" of the Ministry of Health Moscow 123995 Russia Federation department of Pediatric FSBEI HE "Stavropol State Medical University" of the Ministry of Health Stavropol 355002 RussiaFederation department of Biochemistry and of Experimental Medicine The Children's Memorial Health Institute Warsaw Poland

School-aged children and their health conditions, in particular, deficient conditions are not less note worthy than in younger children, while the recognition of present low vitamin d provision in children of all age groups has not still resulted in implementation of mass prophylaxis of hypovitaminosis d. There are several factors on which blood concentration of 25 （OH） d--calcidiol-depends. However, it is evident that among numerous factors we should orient on several most significant and develop correction scheme for the deficient condition in every region. Aim： to assess vitamin d levels in adolescents residing in Moscow, to correct their calcidiol status based on a baseline blood concentration of the transport metabolite. Materials and methods： 769 adolescents aged 11-18 years were examined and their blood concentration of 25 （OH） d was determined. Then, 218 patients were randomized to 2 groups： the treatment group received food supplement ＂Minisun~ vitamin d3＂ in tablets, the control group received placebo. Cholecalciferol dosage was prescribed depending on the baseline calcidiol level in patients. The study continued for 6 months, after that blood was re-withdrawn for calcidiol level. Results： low calcidiol provision was observed among school children： median 25 （OH） d was 16.3 [11.4-20.8] ng/mL, only 5.2% of patients had normal blood concentration of calcidiol. There-examination showed significant differences in vitamin d status in the treatment and control group, in the meantime, during cholecalciferol supplementation, median 25 （OH） d in patients of the treatment group was increased from 16.2 [ 12.25-19.3] ng/mL to 24.2 [21.05-26.4] ng/mL （p 〈 0.001）. Conclusions： the larger part of child population--70.6% has 25 （OH） d concentration 〈 20 ng/mL, cholecalciferol doses used in the study allow eliminating calcidiol deficiency and overcome the boundary of 20 ng/mL, but for normalization of vitamin d status in blood of adolescents residing in Moscow higher dosag

关键词： School-aged children adolescents vitamin d provision vitamin d insufficiency vitamin d deficiency correction of a low vitamin d status.

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