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Journal of Behavioral and Brain Science 2015年第10期5卷 448-457页

作者： Miguel Angel Guevara Jorge Carlos Hevia-Orozco Araceli Sanz-Martin Lucía Ester Rizo-Martínez Marisela Hernández-González Mayra Linné Almanza-Sepúlveda Instituto de Neurociencias CUCBA Universidad de Guadalajara Guadalajara México

Development of the prefrontal cortex and its connectivity with different cortical areas has strong implications for the improvement of working memory. The aim of this research was to characterize the interhemispheric (INTER) prefrontal and hemispheric (INTRA) frontopolar-dorsolateral prefrontal and dorsolateral prefrontal-parietal correlation (r) in children, adolescents and adults during performance of a visuospatial working memory task (VSWM). INTERr and INTRAr of 36 different aged male participants (11 - 13, 18 - 20 and 26 - 30 years old) were calculated during performance of the Corsi Block-Tapping task, which assessed VSWM. On this task, children showed lower correct responses than adolescents and adults. Adults also showed lower total execution times than children and adolescents, with a more efficient performance. On the EEGs, the older groups showed both higher interfrontal correlations and left and right prefronto-parietal correlations than children. According to our results, the progressive efficiency in VSWM is related to differences in EEG patterns among children, adolescents and adults.

关键词： Corsi Block-Tapping Task EEG Correlations Development visuospatial Working Memory

Comparison of novel tools with traditional cognitive tests in detecting delirium in elderly medical patients

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World Journal of Psychiatry 2020年第4期10卷 46-58页

作者： David J Meagher Henry O’Connell Maeve Leonard Olugbenga Williams Fahad Awan Chris Exton Michael Tenorio Margaret O’Connor Colum P Dunne Walter Cullen John McFarland Dimitrios Adamis Cognitive Impairment Research Group Graduate Entry Medical SchoolUniversity of LimerickLimerick V94 YVHOIreland Department of Computer Sciences University of LimerickLimerick V94 YVHOIreland School of Medicine University College DublinDublin 4 D04 V1W8Ireland Sligo Mental Health Services BallytivanSligo F91 CD34Ireland

BACKGROUND Efficient detection of delirium and comorbid delirium-dementia is a key diagnostic challenge.Development of new,efficient delirium-focused methods of cognitive assessment is a key challenge for improved detection of neurocognitive disorders in everyday clinical practice.AIM To compare the accuracy of two novel bedside tests of attention,vigilance and visuospatial function with conventional bedside cognitive tests in identifying delirium in older hospitalized patients.METHODS 180 consecutive elderly medical inpatients(mean age 79.6±7.2;51%female)referred to a psychiatry for later life consultation-liaison service with delirium,dementia,comorbid delirium-dementia and cognitively intact controls.Participants were assessed cross-sectionally with conventional bedside cognitive tests[WORLD,Months Backward test(MBT),Spatial span,Vigilance A and B,Clock Drawing test and Interlocking Pentagons test]and two novel cognitive tests[Lighthouse test,Letter and Shape Drawing test(LSD)-4].RESULTS Neurocognitive diagnoses were delirium(n=44),dementia(n=30),comorbid delirium-dementia(n=60)and no neurocognitive disorder(n=46).All conventional tests had sensitivity of>70%for delirium,with best overall accuracy for the Vigilance-B(78.3%),Vigilance-A(77.8%)and MBT(76.7%)tests.The sustained attention component of the Lighthouse test was the most distinguishing of delirium(sensitivity 84.6%;overall accuracy 75.6%).The LSD-4 had sensitivity of 74.0%and overall accuracy 74.4%for delirium identification.Combining tests allowed for enhanced sensitivity(>90%)and overall accuracy(≥75%)with the highest overall accuracy for the combination of MBT-Vigilance A and the combined Vigilance A and B tests(both 78.3%).When analyses were repeated for those with dementia,there were similar findings with the MBTVigilance A the most accurate overall combination(80.0%).Combining the Lighthouse-SA with the LSD-4,a fail in either test had sensitivity for delirium of 91.4 with overall accuracy of 74.4%.CONCLUSION Bedside tests of attention,vigilance

关键词： visuospatial function Attention Vigilance Letter and Shape Drawing test Lighthouse test Delirium Dementia Phenomenology Assessment

Mild Cognitive Impairment in Parkinson Disease: A Neuropsychological Study of 25 Patients

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World Journal of Neuroscience 2018年第4期8卷 470-479页

作者： Siham Sanhaji Mounia Rahmani Maria Benabdeljlil Mustapha El Alaoui Faris Service of Neurology A and Neuropsychology Rabat Specialty Hospital Rabat Morocco

Parkinson’s disease (PD) is associated with an increased incidence of cognitive impairment and dementia. Population-based cohort of 25 patients with incident PD underwent a large neuropsychological battery. Executive functions were the most affected cognitive domain including particularly initiation, mental flexibility and inhibition. Episodic memory and visuo-spatial functions were less affected. We found that 92% of patients were classified as having Mild Cognitive Impairment (MCI);most of them experienced PD-MCI Single-Domain (17 patients) with disturbances on executive functions. Less frequently, we identified a group of patients with multiple-domain PD-MCI demonstrating deficits on executive functions as well as on episodic memory and/or visuospatial capacities.

关键词： MCI PD Neuropsychological Study Executive Functions Episodic Memory visuospatial Capacities

RompecPC: A computerized program to create and solve jigsaw puzzles

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Journal of Biomedical Science and Engineering 2013年第7期6卷 717-721页

作者： Miguel Angel Guevara Marai Pérez Hernández Marisela Hernández González Araceli Sanz-Martin Sonia Ramírez Zapata Instituto de Neurociencias Centro Universitario de Ciencias Biológicas y Agropecuarias Universidad de Guadalajara Guadalajara México Universidad Autónoma Metropolitana Unidad Xochimilco México D.F. México

RompecPC is a computerized program designed to create and assemble jigsaw puzzles. The program automatically records the solver’s responses as the number of pieces positioned correctly, the number of correct and incorrect movements, the number of times that she/he attempts to move a piece to the same place (perseverations), and the latency and place to which each piece is moved or attempted to be moved. These features facilitate the implementation and evaluation of puzzles while also reducing human error. Therefore, RompePC is a useful tool for the neuropsychological assessment of visuospatial skills in both clinical and experimental research.

关键词： Computerized Testing Neuropsychological Test Jigsaw Puzzles visuospatial Abilities

Spatial orientation during eyes closed versus open in the dark: Are they the same?

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World Journal of Neuroscience 2012年第2期2卷 126-132页

作者： Raymond K. Y. Chong Ben Gibson Scott Horton April Lee Jordan Mellinger Kyoung-Hyun Lee Department of Physical Therapy Georgia Health Sciences University Augusta USA

We hypothesized that keeping one’s balance with eyes open in the dark is different and more difficult than eyes closed because the brain continues to process visual inputs in the dark when the eyes are open. On the other hand, when the eyes are closed, the visual system does not signal incongruent information with which the brain must compare the other sensory systems. A variety of cognitive (subtracting backwards by seven as quickly and accurately as possible) and support surface (fixed versus sway-referenced) conditions were used to probe the neural mechanisms underlying the sensory organization processes in healthy young adults. Peak-to-peak anteroposterior sway performance revealed two dissociated components of the treatment effects. The first component came from the visuospatial factor. Balance control during eye closure and eyes open in the dark were found to be similar but poorer than baseline condition (eyes open under typical lighting). The second component was the effect of task difficulty in which balance control in the sway-referenced condition was worse compared to fixed support during eye closure or eyes open in the dark. Analyses of the cognitive performance also revealed different underlying neural mechanisms of the experimental conditions. Subtraction speed under the fixed support surface condition was similar among all the conditions but was faster with eyes closed during the sway-referenced support surface condition. Accuracy was not affected among the visual and surface conditions. We conclude that sensory processing load with eyes closed is lower than eyes open in the dark, thereby allowing cognitive performance to proceed more efficiently. Performing a difficult subtraction task with eyes closed may afford a decrease in dual-task interference since similar brain areas, particularly the parietal region, are involved in both tasks. The results are discussed with reference to clinical application and spatial disorientation in aviation.

关键词： Attention Balance Computational Neuroscience Dual-Task Modular Theory Parietal Romberg visuospatial

Inner speech, secondary planner in Tower of London task in natural old age

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World Journal of Neuroscience 2012年第1期2卷 47-56页

作者： Maryam Atabati Nader Jahangiri Naghmeh Mokhber Department of Linguistics Ferdowsi University of Mashhad Mashhad Iran Ferdowsi University of Mashhad Mashhad Iran Psychiatry and Behavioral Sciences Research Center of Mashhad University of Medical Sciences Mashhad Iran

In this study the mechanical version of the three-disk Tower of London task with changes in the movements was conducted by fifteen elderly participants with concurrent articulatory suppression. Also, this executive task was conducted without verbal secondary task and the results of these two states were com- pared with each other. From this comparison, got evidences based on inner speech role in more complicated Tower of London tasks, although in general, the results suggest a more outstanding role of inner scribe in spatial planning in this executive task. Then inner speech and inner scribe roles have been described in Tower of London task applying “Baddeley and Logie” working memory model.

关键词： Inner Speech Tower of London Task Phonological Loop visuospatial Sketchpad Articulatory Suppression

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Journal of Behavioral and Brain Science 2019年第12期9卷 395-405页

作者： Kimiko Kato Kazuhito Yoshizaki Department of Psychology Aichi Shukutoku University Nagakute Japan

We investigated if attentional bias directed to the right increased with age. We assessed the characteristics of the following types of eye-gaze by using the Posner cueing paradigm. Younger (n =16) and older (n = 20) adults participated in this study. First of all, a face which looked straight ahead was presented at the center of screen, followed by a gaze cue that looked left or right. Immediately after this informative cue, a target stimulus (“*”) appeared to the left or right of the face. The stimulus-onset asynchrony (SOA) between the cue and the target was selected from 300, 700, and 1100 ms. Participants were required to judge whether the target appeared to the left or the right of the gaze cue as quickly and accurately as possible. Results showed that older adults indicate a larger positive gaze-cueing effect when the eye-gaze shifted rightward, whereas this effect was not observed for a leftward shift. Moreover, a negative gaze-cueing effect (inhibition of return) was observed when the SOA was longer only for the leftward eye-gaze shift of older adults. These modulations of the cueing effect did not appear in younger adults. These findings demonstrate that the rightward attentional bias in older adults is more robust than the leftward bias.

关键词： Aging visuospatial Attention Gaze Cueing Effect Rightward Bias

Visual Selective Attention in Adults with ADHD: Electrophysiological Evidence of Facilitation and Suppression

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Journal of Behavioral and Brain Science 2014年第3期4卷 129-140页

作者： Jane W. Couperus Brittany R. Alperin Dylan Furlong Katherine Mott Hampshire College Amherst USA

This study examined the functioning of facilitation and suppression in visual selective attention in adults with Attention Deficit Hyperactivity Disorder (ADHD). Electrophysiological data were examined in control adults and adults with ADHD during a cued visual spatial selective attention task where in addition to directing attention, the cue probabilistically predicted the presence of a distractor. Late activity following the cue (ADAN) showed attention modulation for all participants. However, only ADHD participants showed additional significant distractor anticipation modulations. Stimulus related activity showed modulations of early visual processing (P1) as a function of attention and anticipated distractor presence for all participants suggesting functional facilitation and suppression. Findings suggest functional visual spatial selective attention in adults with ADHD.

关键词： Adult ADHD Event Related Potentials visuospatial Selective Attention P1 ADAN