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International Journal of Ophthalmology(English edition) 2022年第2期15卷 213-220页

作者： Yu-Fei Zhang Xiao-Hong Zhou Rui-Dan Cao Jun-Bo Song Dong-Yu Wei Fu-Jun Duan Wei Wang Zuo-Ming Zhang Tao Chen Center of Clinical Aerospace Medicine Air Force Medical UniversityXi'an 710032Shaanxi ProvinceChina The Air Force Hospital from Northern Theater PLA Shenyang 110092Liaoning ProvinceChina Ophthalmology Children's Hospital of Fudan UniversityNational Children's Medical CenterShanghai 201102China Basic Medical College Air Force Medical UniversityXi'an 710032Shaanxi ProvinceChina Department of Aviation Medicine Air Force Hospital of Southern Theater CommandGuangzhou 510062Guangdong ProvinceChina Naval Medical Center of PLA Shanghai 200433China Department of Aviation Medicine Xijing HospitalAir Force Medical UniversityXi5an 710032Shaanxi ProvinceChina

AIM:To explore the effects of laser-activated remote phosphors(LARP)on visual function in guinea ***:Electroretinogram(ERG)of guinea pigs were observed after LARP irradiation at different frequencies and irradiation *** evaluated the expression of rhodopsin,β-catenin,connexin36,calretinin,and calbindin in the retina of guinea pigs and measured the density of photoreceptor cells after high-frequency LARP ***:After LARP irradiation,the ERG results showed that the amplitude of the dark-adapted 3.0 b-wave of the model eye was lower than that of the control eye after high-frequency irradiation(Pvisual protection policies under LARP lighting conditions.

关键词： irradiation visual function visual protection retina

The Study of Relationships between the Damage of visual function and Hemorrheology, Ocular Rheography, as well as Other Related Factors in Patients with Primary Open Angle Glaucoma (POAG)

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眼科学报 1993年第1期9卷 3-11页

作者： Jian Ge, Wenbing Zhou National Ophthalmological Laboratories, Ministry of Public Health, China, Zhongshan Ophthalmic Center, Sun Yat-Sen University of Medical Sciences, Guangzhou 510060, China Jiancu Zhu, Anheng Cheng, Yulan Lin, Hongyan Tong, Lin Lian, Zhixing Chen Institute of Cardiovascular Diseases of Guangdong Province, Guangzhou 510080, China National Ophthalmological Laboratories Ministry of Public Health China.

Researches of glaucoma visual function damage, hemorrheololgy, ocular rheography and other related multiplex factors, with computed multifactorial stepwise regresion analysis, indicate that the elevation of intraocular pressure (IOP) is not the only factor to induce visual impairment. POAG patients are shown to have markedly reduced diastolic purfussion pressure in ophthalmic artery, besides prolonged filling time of the retinal artery and vein, diminished erythrocyte deformability and increased platele...

关键词： visual function hemorrheology primary open angle glaucoma (POAG) ocular rehography intraocular pressure (IOP) blood cells trace elements multiphy stepwise regression.

Neurexin regulates visual function via mediating retinoid transport to promote rhodopsin maturation

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Neurexin regulates visual function via mediating retinoid tr...

Evaluation of visual functional and morphology change in young patients with idiopathic choroidal neovascularization

中国神经科学学会第十届全国学术会议

作者： Yao TIAN Tao LI Mingkuan SUN Didi WAN Qian LI Peipei LI Zi Chao ZHANG Junhai HAN Wei XIE Institute of Life Sciences the Key Laboratory of Developmental Genes and Human DiseaseSoutheast University

Neurexins are cell adhesion molecules involved in synapse formation and synaptic *** in the neurexin genes are linked to a number of neurodevelopmental disorders such as ***,we show that the Drosophila homolog of a-Neurexin is critical for fly visual *** of Neurexin leads to significantly impaired visual function due to reduced rhodopsin *** show that the decreased chromophore levels cause deficits in rhodopsin maturation and that Neurexin is required for retinoid *** yeast two-hybrid screening,we identify that Neurexin interacts with apolipoprotein I（ApoL I）,a product generated by cleavage of retinoid- and fatty acid-binding glycoprotein（RFABG） that functions in retinoid ***,we demonstrate that Neurexin is essential for the apohpoproteins *** results reveal a role for Neurexin in mediating retinoid transport and subsequent rhodopsin maturation and suggest that Neurexin regulates lipoprotein function.

关键词： neurexin visual function rhodopsin membrane protein maturation retinoid retinoid-and fatty acid-binding glycoprotein apolipoprotein I

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Chinese Medical Journal 2011年第11期124卷 1647-1652页

作者： WANG Wen-qiu LIU Hai-yun LU Feng-qing HU Wei-ting GONG Yuan-yuan WU Ying XU Shan WANG Wei-jun XU Xun WANG Feng-hua SUN Xiao-dong Department of Ophthalmology Shanghai First People's HospitalAffiliated to Shanghai Jiao Tong University Shanghai 200080China Shanghai Key Laboratory of Ocular Fundus Diseases Science andTechnology Commission of Shanghai Municipality Shanghai200080 China

Background Idiopathic choroidal neovascularization （ICNV） is an uncommon disorder affecting primarily individuals younger than the age of 50 years. In CNV patients, no apparent cause can be determined. This study aimed to evaluate the functional and morphological change of the retina with ICNV in young adults. Methods In this retrospective study, 32 eyes of 32 patients with subfoveal or juxta/extra foveal ICNV had been admitted into the Shanghai First People＇s Hospital from January 2009 to July 2010. The functional changes were evaluated using the best corrected visual acuity （BCVA） and the microperimetry in the macular area.

关键词： idiopathic choroidal neovascularization optical coherent tomography microperimetry visual function

Diabetic retinopathy: recent advances towards understanding neurodegeneration and vision loss

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Science China(Life Sciences) 2015年第6期58卷 541-549页

作者： BARBER Alistair J. Penn State Hershey Eye Center Penn State Hershey College of Medicine Milton S. Hershey Medical Center

Diabetic retinopathy （DR） is one of the most common retinal diseases world-wide. It has a complex pathology that involves the vasculature of the inner retina and breakdown of the blood-retinal barrier. Extensive research has determined that DR is not only a vascular disease but also has a neurodegenerative component and that essentially all types of ceils in the retina are affected, leading to chronic loss of visual function. A great deal of work using animal models of DR has established the loss of neurons and pathology of other cell types, including supporting glial cells. There has also been an increased emphasis on measuring retinal function in the models, as well as further validation and extension of the animal studies by clinical and translational research. This article will attempt to summarize the more recent developments in research towards understanding the complexities of retinal neurodegeneration and functional vision loss in DR.

关键词： retina diabetes neurodegeneration visual function vascular function apoptosis synapse dendrite

Effect of carotenoids dietary supplementation on macular function in diabetic patients

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Eye and Vision 2017年第1期4卷 137-142页

作者： Marilita M.Moschos Maria Dettoraki Michael Tsatsos George Kitsos Christos Kalogeropoulos First Department of Ophthalmology Medical SchoolNational and Kapodistrian University of Athens6 Ikarias streetEkali14578 AthensGreece Department of Ophthalmology Medical SchoolAristotle University of ThessalonikiThessalonikiGreece Department of Ophthalmology Medical SchoolUniversity of IoanninaIoanninaGreece

Background:Diabetic retinopathy is a major cause of visual impairment and blindness among working-age people *** aim of our study was to investigate the effects of a carotenoid supplementation on retinal thickness and macular function of patients with diabetes using optical coherence tomography(OCT)and multifocal electroretinography(mfERG).Methods:A retrospective study of one hundred and twenty eyes of sixty patients age between 40 and 60 years with non-insulin dependent type 2 diabetes mellitus without diabetic retinopathy who underwent OCT and mfERG and took vitamin supplements for a period of two *** received a carotenoid supplement containing lutein(10 mg),zeaxanthin(2 mg)and meso-zeaxanthin(10 mg)once a day for two *** thickness of the fovea was evaluated using OCT and the macular function was tested by ***:OCT showed an increase in the central foveal thickness and mfERG revealed increased retinal response density within the central 13°surrounding the fovea(rings 1 to 3)at two years after the onset of carotenoids supplement ***:The use of carotenoid supplements may be of benefit for improving visual function of type 2 diabetes ***,further study is needed to assess the treatment’s long-term efficacy.

关键词： Carotenoids Diabetes mellitus visual function Multifocal electroretinography Optical coherence tomography

Umbilical cord derived mesenchymal stem cell implantation in retinitis pigmentosa: a 6-month follow-up results of a phase 3 trial

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International Journal of Ophthalmology(English edition) 2020年第9期13卷 1423-1429页

作者： Neslihan Sinim Kahraman Ayse Oner Department of Ophthalmology Kayseri Acibadem HospitalKayseri 38030Turkey

AIM:To investigate the efficacy and the safety of umbilical cord derived mesenchymal stem cell(UC-MSC)implantation in patients with retinitis pigmentosa(RP).METHODS:This prospective,single-center,phase 3 clinical study enrolled 124 eyes of 82 RP *** patients received 5 million UC-MSCs to the suprachoroidal area with a surgical *** were evaluated on the 1st day,1st,and 6th months *** corrected visual acuity(BCVA),anterior segment and fundus examinations,color photography,optical coherence tomography(OCT),and visual field(VF)tests were carried out at each *** fluorescein angiography(FFA)and multifocal electroretinography(mfERG)recordings were performed at the end of the 6th *** and systemic adverse events of the surgical procedure were also ***:All of the 82 patients completed the 6-month follow-up *** of them had any serious systemic or ocular *** were statistically significant improvements in BCVA and VF during the study(all P<0.05).The amplitudes of the P1 waves in the central areas showed significant improvements in mfERG *** were also significant increases in implicit times of P1 waves in the central ***:Suprachoroidal administration of UC-MSCs has beneficial effect on BCVA,VF,and mfERG measurements during the 6-month follow-up *** mediated therapy based on the secretion of growth factors(GFs)seems to be an effective and safe option for degenerative retinal diseases.

关键词： cell mediated therapy retinitis pigmentosa suprachoroidal umbilical cord derived mesenchymal stem cells visual function

Comparison of visual outcomes with implantation of trifocal versus bifocal intraocular lens after phacoemulsification: a Meta-analysis

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International Journal of Ophthalmology(English edition) 2018年第3期11卷 484-492页

作者： Juan-Juan Yang Qiu-Ping Liu Jing-Ming Li Li Qin Department of Ophthalmology First Affiliated Hospital of Xi'an Jiaotong University Department of Ophthalmology Affiliated Eye Hospital of Nanchang University

AIM： To compare a trifocal intraocular lens （IOL） and a bifocal IOL implantation in improving visual function after cataract surgery. METHODS： Eligible literatures were systematically searched through EMBASE and PubMed databases. The inclusion criteria were prospective comparative clinical trials on cataract surgery comparing trifocal IOL with bifocal IOL implantation that assessed visual acuity, contrast sensitivity and subjective vision quality. The effects were computed as standardized mean differences and pooled using fixed-effect or random-effect models. RESULTS： Four prospective randomized controlled trials （RCTs） and five cohorts provided data were included by a systematic review, comprising 265 eyes implanted with trifocal IOLs and 264 eyes implanted with bifocal IOLs. Monocular distance visual acuity （VA） showed a statistically significant but small difference that favored trifocal IOLs （MD=.0.06; 95%CI, -0.10 to -0.02; Z=2.90, P=0.004 for uncorrected distance VA, and MD- -0.02; 95%CI, -0.03 to .0.00; Z=2.02, P=0.04 for corrected distance VA）, but the data did not suggest that the effect of trifocal IOL implantation would clinically outperform bifocal IOL implantation. There was no significant difference in monocular near VA （MD=.0.01; 95%CI, -0.07 to 0.04; Z=0.42, P=-0.68 for distance-corrected near VA, and MD=-0.01; 95%CI, -0.06 to 0.03; Z=0.55, P=0.58 for corrected near VA） or refraction between two groups. Contrast sensitivity and subjective visual quality had no conclusive results. CONCLUSION： All results indicate that trifocal IOL and bifocal IOL had similar levels of monocular distance and near VA.

关键词： trifocal intraocular lens bifocal intraocularlens visual function Meta-analysis

Low-dimensional optoelectronic synaptic devices for neuromorphic vision sensors

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Materials Futures

Materials Futures 2023年第3期2卷 72-89页

作者： Chengzhai Lv Fanqing Zhang Chunyang Li Zhongyi Li Jing Zhao School of Mechatronical Engineering Beijing Institute of TechnologyBeijing 100081People’s Republic of China Beijing Advanced Innovation Center for Intelligent Robots and Systems Beijing Institute of TechnologyBeijing 100081People’s Republic of China

Neuromorphic systems represent a promising avenue for the development of the next generation of artificial intelligence *** vision,one of the cores in artificial intelligence,requires system-level support with low power consumption,low latency,and parallel *** vision sensors provide an efficient solution for machine vision by simulating the structure and function of the biological *** synapses,which use light as the main means to achieve the dual functions of photosensitivity and synapse,are the basic units of the neuromorphic vision ***,it is necessary to develop various optoelectronic synaptic devices to expand the application scenarios of neuromorphic vision *** review compares the structure and function for both biological and artificial retina systems,and introduces various optoelectronic synaptic devices based on low-dimensional materials and working *** addition,advanced applications of optoelectronic synapses as neuromorphic vision sensors are comprehensively ***,the challenges and prospects in this field are briefly discussed.

关键词： optoelectronic synaptic neuromorphic vision sensors synaptic plasticity low-dimensional visual function

Virtual reality training improves accommodative facility and accommodative range

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International Journal of Ophthalmology(English edition) 2022年第7期15卷 1116-1121页

作者： Dong-Yu Guo Yuan-Yuan Shen Miao-Miao Zhu Yang-Yang Zhan Xia-Wei Wang Jian-Hua Xia Bo Jiang Yang-Shun Gu Yan Long Department of Ophthalmology First Affiliated Hospital of Zhejiang UniversityHangzhou 310000Zhejiang ProvinceChina Department of Internal Medicine Liangzhu HospitalYuhang DistrictHangzhou 310000Zhejiang ProvinceChina Department of Ophthalmology Shulan HospitalHangzhou 310000Zhejiang ProvinceChina

AIM: To evaluate the effects of virtual reality(VR) training on different parameters of ***: Sixty individuals ranged 18-60 years old with asthenopia were randomly divided into short-term(n=40) and long-term(n=20) treatment groups. They were given a specially designed VR training device only once for 15 min or 3-4 times a day for 15 min each time for 1 mo. The visual acuity, spherical equivalent, accommodative range, accommodative facility, pupil size, and visual fatigue were evaluated before(control) and after VR training. RESULTS: The visual acuity, accommodative range, and accommodative facility increased in subjects of the shortterm treatment group, whereas their pupil size contracted significantly. No significant changes in spherical equivalent and visual fatigue were observed. The changes in distant vision and corrected visual acuity were positively correlated with those in pupil size, but not with spherical equivalent. The accommodative range and accommodative facility improved significantly in subjects of the long-term treatment group. No significant changes in visual acuity, spherical equivalent, pupil size, and visual fatigue were noted. CONCLUSION: VR training can improve the accommodative range and accommodative facility of human eyes. Although short-term VR training can transiently improve vision, which probably due to bright light adaptation, there is no evidence that it can improve myopia.

关键词： virtual reality visual function myopia visual fatigue accommodation