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The effect of docosahexaenoic acid on visual evoked potentials in aged mice

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The effect of docosahexaenoic acid on visual evoked potentia...

Normalization of auditory evoked potential and visual evoked potential in patients with idiot savant

第十七届国际生物物理大会;第十二届中国生物物理大会

作者： Aysel Agar ozlem ozsoy Piraye yargycoglu Akkiraz Mutay aslan Akdeniz University Faculty of MedicineDepartment of PhysiologyAntalyaTurkey Akdeniz University Faculty of MedicineDepartment of BiophysicsAntalyaTurkey Akdeniz University Faculty of MedicineDepartment of BiochemistryAntalyaTurkey

This study aimed to investigate the effect of docosahexaenoic acid(DHA) on visual evoked potentials(VEPs) in aged *** months old C57BL/6 mice were divided as control and DHA-treated(DHA) *** was given daily by gavage for 4 *** were recorded with sub-dermal needle electrodes placed on the head. Retina antioxidant enzyme activities were determined by spectrophotometric *** concentration of

关键词： Docosahexaenoic acid visual evoked potentials Antioxidant enzymes TBRS Aged mice

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Chinese Medical Journal 1999年第3期112卷 54-56页

作者：陈兴时张明岛王继军楼翡璎梁建华 Shanghai Institute of Mental Health Shanghai 200030 China

Objective To investigate the variations of auditory evoked potentials (AEP) and visual evoked potentials (VEP) of patients with idiot savant (IS) syndrome. Methods Both AEP and VEP were recorded from 7 patients with IS syndrome, 21 mentally retarded (MR) children without the syndrome and 21 normally age matched controls, using a Dantec concerto SEEG 16 BEAM instrument. Results Both AEP and VEP of MR group showed significantly longer latencies (P1 and P2 latencies of AEP, P<0.01; N1 and N2 latencies of VEP, P< 0.01/0.05), lower P2 amplitudes (P<0.01) and higher P3 amplitudes (P<0.01), as compared with normal controls. But none of above mentioned changes was found with IS group. Almost all MR patients (90.1%) presented P4 component in both AEP and VEP, which was also in sharp contrast with its incidence in other 2 groups (IS: 14.3%; normal controls: 9.5%). Conclusion Patients with idiot savant syndrome presented normalized AEP and VEP.

关键词： auditory evoked potentials visual evoked potentials idiot savant mental retardation

visual pathways involvement in clinically isolated syndrome in children

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International Journal of Ophthalmology(English edition) 2015年第2期8卷 382-384页

作者： Vladislav Voitenkov Natalia Skripchenko Andrey Klimkin Scientific Research Institute of Children's Infections Professora Popova 9

AIM: To investigate extent and nature of visual pathways involvement in children with clinically isolated syndrome(CIS).METHODS: Forty-seven patients(age 11-17y) with CIS, which later proved to be multiple sclerosis(MS)onset, and 30 controls underwent visual evoked potentials(VEP) investigation within 12 d from the appearance of the first signs of disease. Latency and amplitude of P100 peak were compared with normative data and between ***: In 58% patients, including those without signs of retrobulbar neuritis, significant slowing of conduction along the central visual pathways(P100latency lengthening) is seen. P100 amplitudes drop(signs of axonal damage) are registered less frequently(29% cases).CONCLUSION: The results indicate that visual pathways are often affected in the MS onset; mostly demyelination signs are seen. Despite MRI significance for MS diagnostic, VEPs proved to be still effective in early diagnosis of MS in children.

关键词： visual evoked potentials multiple sclerosis clinically isolated syndrome children visual pathway

The Exact Estimation of visual Acuity by VEP Technology:A Report of 726 Cases of Eye Injury

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2010年第1期30卷 138-140页

作者：饶广勋吴炳为张玲莉 Faculty of Forensic Medicine Tongji Medical CollegeHuazhong University of Science and Technology

This study explored the accuracy of using visual evoked potentials(VEP)technology for visual acuity *** enrolled 726 patients with post-traumatic unilateral decrease in visual acuity included the injured eyes served as the experimental group,and the healthy eyes as the control *** least signal visual angle(LSVA),and amplitude and latency of P100 were chosen as test *** results under different experimental conditions were recorded by PRVEP *** data collected were processed...

关键词： clinical forensic medicine visual evoked potentials visual acuity least signal visual angle amplitude and lateny of P100

Single-trial EEG classification using in-phase average for brain-computer interface

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Frontiers of Electrical and Electronic Engineering in China 2008年第2期3卷 194-197页

作者： Jin’an GUAN Yaguang CHEN School of Electronic Engineering South-Central University for NationalitiesWuhan 430074China

Communication signals should be estimated by a single trial in a brain-computer *** the relativity of visual evoked potentials from different sites should be stronger than those of the spontaneous electro-encephalogram(EEG),this paper adopted the time-lock averaged signals from multi-channels as features.200 trials of EEG recordings evoked by target or non-target stimuli were classified by the support vector machine(SVM).Results show that a classification accuracy of higher than 97%can be obtained by merely using the 250–550 ms time section of the averaged signals with channel Cz and Pz as *** suggests that a possible approach to boost communication speed and simplify the designation of the brain-computer interface(BCI)system is worthy of an attempt in this way.

关键词： in-phase average visual evoked potentials brain-computer interfaces single-trial estimation

*** stem cells repair retinal vascular damage in retinopathy of prematurity mouse model

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Annals of Eye Science 2018年第1期 434-434页

作者： Baraa Noueihed Jose Carlos Rivera Sylvain Chemtob Department of Pharmacology McGill UniversityMontréalQCCanada Research Center Hôpital Maisonneuve-Rosemont Universitéde MontréalMontréalQCCanada Research Center CHU Sainte-Justine Universitéde MontréalMontréalQCCanada Department of Pharmacology Universitéde MontréalMontréalQCCanada Department of Ophthalmology Universitéde MontréalMontréalQCCanada Department of Pediatrics Universitéde MontréalMontréalQCCanada

Background:Retinopathy of prematurity is a leading cause of visual impairment and blindness in *** of premature babies to the hyperoxic extrauterine environment leads to vaso-obliteration(VO),followed by ischemia,and subsequently pathological intravitreal neovascularization(NV)in the immature *** treatments target only aberrant intravitreal vessel growth without repopulating the avascular regions of the ***,there is a dire need of new therapies that arrest pathological NV and promote normal retinal *** stem cells(MSCs)have shown the ability to migrate to the damaged tissue in different animal models and enhance ***,therefore,investigated whether MSCs can promote vascular repair in a mouse model of ***:Oxygen-induced retinopathy(OIR)model was used *** day 7(P7)mice were subjected to 75%O2 until P12 to induce VO followed by 5 days of room air leading to *** bone-derived MSCs were isolated from adult C57BL/6 mice and cultured either in hypoxia(5%O2)or normoxia(21%O2).Conditioned media(CM)was collected 24 hours later and injected intravitreally in P12 OIR retinas to assess vascular *** determine possible factors involved in MSC-induced revascularization,gene expression analysis was performed on P17 OIR *** vitro,we investigated the effect of MSC-CM on microglial polarization using quantitative PCR and flow ***:Hypoxic MSC-CM significantly(P<0.01)decreased both VO and NV areas in comparison to the normoxic *** of IGF-1 and VEGF were significantly high in MSC-injected OIR ***,gene expression levels of pro-inflammatory cytokines(IL-1β,TNFα)dropped whereas levels of anti-inflammatory cytokines(IL-10,IL-4)*** of pro-inflammatory M1 microglia with MSC-CM decreased the gene expression of IL-1βand TNFα,and iNOS(M1 marker)at the transcript and protein ***:In this study,we demonstrated that MSCs

关键词： Optokinetics visual evoked potentials Nogo-A 11C7

***-A neutralisation improves vision recovery after retinal injury

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Annals of Eye Science 2018年第1期 433-433页

作者： Julius Baya Mdzomba Sandrine Joly Léa Rodriguez Frédéric Bretzner Vincent Pernet CUO-Recherche Centre de recherche du CHU de Québec et Département d'ophtalmologieFacultéde médecineUniversitéLavalQuébecQuébecCanada CUO-Recherche Centre de Recherche du CHU de QuébecDépartement de psychiatrie et neurosciencesFacultéde MédecineAxe Neurosciences et UniversitéLavalQuébecQuébecCanada

Background:In glaucoma and after an ischemic injury of the retina,excessive activation of N-Methyl-D-Aspartate receptors,a type of glutamatergic receptors,induces the death of retinal ganglion cells and an irreversible vision *** painless loss of retinal cells does not allow for a swift diagnostic and treatment of retinal *** is no efficient therapy to improve retinal functions in this *** order to develop new therapeutic approaches for retinal injury,we propose,in this study,to stimulate neuronal plasticity of the visual system by neutralising the glial protein,*** inhibitory action of this protein on axonal regeneration is well known in spinal cord injuries but not in the visual *** thus studied the function of Nogo-A in vision recovery in ***:Nogo-A activities were chronically blocked by deleting its gene in KO mice and acutely,by intravitreal injections of an antibody known as *** retina lesions were done by injection of 0.5 or 5 nmol of NMDA in the vitreous humor.A PBS buffer was administered in control *** visual system functions were accessed with an optokinetic test in awake mice,by electroretinography(ERG)in the eye and visual evoked potentials in the visual *** survival of retinal ganglion cells,amacrine and bipolar cells was evaluated on histological sections by *** in expression of Nogo-A,its receptors and neuronal plasticity associated molecules were observed by Western blot and ***:At NMDA doses of≤0.5 nmol,Nogo-A KO mice show a recovery of optokinetic responses much faster than in WT ***,a single injection of the antibody,11C7 was sufficient to improve VEPs of NMDA injured animals as compared to control ***,ERGs showed that a dose of 0.5 nmol induced retinal lesions limited to the ganglion cell layer,with significant changes to the VEPs but without influencing photoreceptors and inner nuclear layer cells ***,5 n

关键词： Optokinetics visual evoked potentials Nogo-A 11C7