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International Journal of Ophthalmology(English edition) 2021年第5期14卷 704-713页

作者： Xia Wang Ruo-Shi Li Ya-Hui Wei Yuan Fang Tian Tian Mei Li Ying-Zi Pan Department of Ophthalmology Peking University First HospitalBeijing 100034China

AIM:To explore the diagnostic performance of isolatedcheck visual evoked potential(ic VEP)for primary open angle glaucoma(POAG)in both highly myopic and nonhighly myopic populations and compare it with those of optical coherence tomography(OCT)and Heidelberg retinal tomography(HRT)***:A total of 126 participants were recruited,including 31 highly myopic participants with POAG(HM-POAG),36 non-highly myopic participants with POAG(NHM-POAG),25 highly myopic participants without POAG(HM)and 34 controls without high myopia(Normal).All the participants underwent a complete ophthalmic *** signal-to-noise ratio(SNR)was used to assess the ic *** qualitative and quantitative diagnostic performances of OCT,HRT and the ic VEP were analyzed and ***:Based on the criterion of SNR≤1,the diagnostic performance of the ic VEP in highly myopic subjects[area under the receiver operating characteristic curve(AUC)=0.862]was better than that in non-highly myopic subjects(AUC=0.789),and the SNR had fairly good *** distinguishing the HM-POAG and HM groups,the AUC of the SNR was not different from those of the OCT and HRT parameters(P>0.05)in either the qualitative or quantitative *** the qualitative analysis,the ic VEP showed good consistency with damage to the central 10°of the visual field(kappa=0.695-0.747,Ppotential to discriminate individuals with and without POAG,especially in populations with high myopia.

关键词： primary openangle glaucoma high myopia isolated check visual evoked potential diagnosis

Characteristics of Pattern visual evoked potential in Two Eyes with Varying visual Acuity in One Eye and Forensic Application

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Current Medical Science 2018年第2期38卷 342-348页

作者： Fu-quan JIA Yu-guang LIANG Xin-yuan ZHANG Fang-liang LUO Yan-he XIONG Long-long CHENG Ji-hui LIU School of Forensic Medicine China Medical University Shenyang 110122 China Department of Forensic Medicine Inner Mongolia Medical University Hohhot 010059 China Beijing Scales Forensic Center Beijing 100025 China

In this study, we aimed to study the pattern visual evoked potentials （P-VEPs） in two eyes with varying visual acuity in one eye and to provide an objective estimation of visual acuity by comparing P-VEPs in one and two eyes. Thirty subjects were chosen, who had one eye with an acuity of 5.0, 4.85, 4.6, 4.0, or scieropia and obstructed vision and the other eye with an acuity of 5.0, respectively. P-VEPs were detected under the large grating stimuli at 3x4 spatial frequency, moderate grating stimuli （12× 16 spatial frequency） and small grating stimuli （48×64 spatial frequency）. Under large grating stimuli, there was no significant difference in P100 peak latency between the groups, nor was there a significant difference between the amplitude of two eyes and the amplitude of one normal-vision eye. Under moderate and small grating stimuli, there was a significant difference in P100 peak latency between the group with both eyes having an acuity of 5.0 and the group with visual acuity below 4.0 in one eye. There was a significant difference in P100 amplitude between the group with visual acuity of 5.0 in both eyes and the group with one normal-vision eye. There was no significant difference in the amplitude of two eyes and the amplitude of one normal-vision eye between any other two groups. In forensic identification, characteristics and variability of P-VEPs in one and two eyes can be used to identify malingering or decline in visual acuity.

关键词： visual evoked potential decline in visual acuity two eyes forensics

visual evoked potential and Brainstem Auditory evoked potential in patients with Parkinson Disease

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Visual Evoked Potential and Brainstem Auditory Evoked Potent...

Applications of Isolated-Check visual evoked potential in Early Stage of Open-Angle Glaucoma Patients

2018年浙江省老年精神障碍学术年会

作者：刘春艳何松彬浙江省舟山医院

Patients with Parkinson disease(PD) may have sensory dysfunction and it can be more easily demonstrated through electrophysiologic *** aimed to explore whether the impairment of brainstem visual and auditory passageway exists in PD patients by using visual evoked potential(VEP) and brainstem auditory evoked potential(BAEP) examinations.42 PD cases and 30 controls,participated in the *** the subjects underwent the VEP and BAEP *** showed that the N75,P100,N145 latencies of VEP,but not the amplitude of P100,were significantly longer in PD patients than the control group(P visual and auditory passageway may be impaired in PD *** and BAEP can be served as sensitive measurements in helping the prognosis and monitoring the developing of PD.

关键词： Parkinson disease visual evoked potential brainstem auditory evoked potential,latency,interpeak latency,dopa dose,Unified Parkinson Disease Rating Scale

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Chinese Medical Journal 2018年第20期131卷 2439-2446页

作者： Xiang Fan Ling-Ling Wu Xia Di Tong Ding Ai-Hua Ding Department of Ophthalmology Peking University Third Hospital Beijing 100191 China Beijing Key Laboratory of Restoration of Damaged Ocular Nerve Peking University Third Hospital Beijing 100191 China Department of Ophthalmology Qingdao Sanatorium of Shandong Province Qingdao Shandong 266071 China

Background： Standard automated perimetry does not sufficiently detect early open-angle glaucoma （OAG） in the clinic. New visual function tests for early glaucoma damage are therefore needed. The present study evaluated whether an isolated-check visual evoked potential （icVEP） could be used to detect visual function abnormalities in early-stage OAG and to explore potential related factors. Methods： This was a cross-sectional study. Thirty-seven OAG patients with early-stage visual field loss （mean deviation ≥ -6.00 dB） detected by the Humphrey Field Analyzer （30-2 SITA program） and 26 controls were included in this study. Optical coherence tomography （OCT） was used to detect retinal nerve fiber layer （RNFL） defects. The icVEP preferentially evaluates the magnocellular-ON pathway. VEPs were recorded and signal-to-noise ratios （SNRs） were derived based on multivariate analysis. Eyes that yielded an SNR ≤1 were considered abnormal. Receiver operating characteristic （ROC） curve analysis was used to estimate the accuracy of group classification. Correlations between SNRs and related factors were analyzed. Results： Based on an SNR criterion of 1, the icVEP had a sensitivity of 62.2% and a specificity of 92.3% for diagnosing early-stage OAG with 74.6% classification accuracy. The ROC curve analysis, however, suggested that an SNR criterion of 0.93 would produce the highest classification accuracy （77.3%）. Both RNFL thinning in the temporal superior quadrant on OCT and number of abnormal test points in the central 11° visual field （pattern deviation, P 〈 0.5%） significantly correlated with the SNR （P 〈 0.05）. Conclusions： The icVEP detected visual function abnormalities in approximately 3/5 of eyes with early-stage OAG with greater than 90% specificity. SNR correlated with both a decrease in RNFL thickness and severity of central visual field loss.

关键词： Cross-Sectional Study Isolated-Check Open-Angle Glaucoma Signal-To-Noise Ratios visual evoked potential

Effect of visual stimulus locations on pattern-reversal visual evoked potential An epidural electrocorticogram study

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Neural Regeneration Research 2011年第26期6卷 2042-2046页

作者： Wensheng Hou Weiwei Shi Xiaolin Zheng Na Liu Zongxia Mou Yingtao Jiang Zhengqin Yin Key Laboratory of Biorheological Science and Technology （Chongqing University） Ministry of Education Bioengineering College Chongqing University Chonqqing 400044 China Department of Ophthalmology Southwest Hospital Third Military Medical University of Chinese PLA Chongqing 400038 China Department of Electrical and Computer Engineering University Of Nevada Las vegas NV 89154 USA

To explore the effect of the location of a visual stimulus on neural responses in the primary visual cortex （V1）, a micro-electromechanical system-based microelectrode array with nine channels was implanted on the cerebral dura mater of V1 in adult cats. 2 Hz pattern reversal checkerboard stimul were used to stimulate the four visual quadrants （i.e., upper left, upper right, lower left, and lower right fields）. The results showed that there was a N75 component of the visual evoked potential around 50-80 ms after the onset of a checkerboard stimulus, and the onset of these N75 peaks varied with different stimulus locations. The checkerboard stimuli Jnduced shorter latencJes in the contralateral V1 than in the ipsilateral V1, while the checkerboard stimulus in the upper half visual field induced shorter latencies for N75. These results suggested that the pattern-reversal stimuli induced neural activities in V1 that can be recorded with multichannel microelectrodes, and more detailed temporal and spatial properties can be measured.

关键词： checkerboard cerebral dura mater visual evoked potential microelectrode array primary visual cortex

Appropriate stimulation in visual evoked potential to evaluate visual perception state of athletes

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Neural Regeneration Research 2008年第6期3卷 666-669页

作者： Yunxiang Li Yuzhen Zhu Physical Education College Linyi Normal University Linyi 276005 Shandong Province China

BACKGROUND： Several studies have demonstrated that visual evoked potentials can be influenced by sport events. To the best of our knowledge, there are no specific parameters for the most appropriate stimulation for evaluating the functional state of athletes. OBJECTIVE： To investigate the best stimulation in visual evoked potential to apply to functional evaluation of athletes. DESIGN, TIME AND SETTING： Ninety-five, healthy students from the Shandong Normal University took part in an observational, contrast study. PARTICIPANTS： All active participants were male. Sixty-five students majored in physical education, and had participated in exercise for the duration of （4.26 ± 3.08） years. An additional 30 students majored in other subjects. METHODS： The neural electricity tester, NDI-200, was adapted to examine and record visual evoked potential with varying probes using bipolar electrodes attached to the head of all the participants in a dark room. The visual evoked potential values were analyzed transversally. A chessboard pattern reversal method was applied with the following parameters： 2 Hz stimulation frequency, brightness of 90 cdp, 80% contrast, 1-100 Hz bandpass filters, and 10 μV sensitivity; 100 responses were averaged. MAIN OUTCOME MEASURES： latency, peak latencies, and inter-peak latencies were measured in N75, P100, N145 with varying probe stimulations. RESULTS：（1） Comparisons between the little check, middle check, and big check stimulation, demonstrated that the common tendencies in visual evoked potential indexes of the two groups of N75 latency were successively shorter and N145 were longer. P100-N145 peak latency was decreased and each inter-peak latency was longer. （2） Changes of N75, P100, and N145 with different check stimulations in the physical education student group： after compared with the middle check stimulation, N75 latency was significantly longer （P 〈 0.01）, and N75-P100 inter-peak latency （P 〈 0.05） and N75-N145 inter-peak latency were

关键词： visual evoked potential functional evaluation probe stimulation

Application of monitoring lumpectomy of lesion adjacent to the optic radiation using real-time visual evoked potential and diffusion tensor tractography

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Application of monitoring lumpectomy of lesion adjacent to t...

Meta-analysis of visual evoked potential and Parkinson's disease

中华医学会神经外科学分会第九次学术会议

作者：赵鹏来张岩松 Department of Neurosurgery Nanjing Brain Hospital Affiliated to Nanjing Medical University

Objective The exactanatomical relationship of the optic radiation fibers are impossibly visualized on conventional imaging *** has been difficult to obtain anatomic and functional information about the visual pathway ... 详细信息

关键词： optic radiation diffusion tensor tractography visual evoked potential neuronavigation

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Meta-analysis of visual evoked potential and Parkinson's dis...

visual evoked potential by implanted scalp electrode in rats

2018年浙江省老年精神障碍学术年会

作者：何松彬刘春艳浙江省舟山市温州医科大学附属舟山医院神经内科

Background:Previous studies suggested that visual evoked potential(VEP) was impaired in patients with Parkinson’ s disease(PD),but the results were ***:We conducted a systematic review and meta-analysis to explore whether the VEP was significantly different between PD patients and healthy ***-control studies of PD were selected through an electronic search of the databases(Pubmed,Embase and the Cochrane Central Register of Controlled Trials).We calculated the pooled weighted mean differences(WMDs) and 95% confidence intervals(CIs) between individuals with PD and controls using the random-effects ***:We found that the P100 latency in PD was significantly higher compared with healthy controls(pooled WMD=6.04,95% Cl:2.73 to 9.35,P=0.0003).However,the difference in mean amplitude of P100 was not significant between the two groups(pooled WMD=0.64,95% CI:-0.06 to 1.33,P=0.07) based on 10 studies with the P100 amplitude values ***:The higher P100 latency of VEP was observed in PD patients,relative to healthy *** findings suggest that electrophysiological changes and functional defect in visual pathway of PD patients,which is important to our understanding of the pathophysiology of visual involvement in PD.

关键词： Parkinson’s disease visual evoked potential Meta-analysis Weighted mean difference

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International Journal of Ophthalmology(English edition) 2011年第2期4卷 220-220页

作者： Qun Guo,Bei Xie,Yong-Hao Gu,Jing An,Feng Xia,Zuo-Ming Zhang Department of Clinical Aerospace Medicine,Faculty of Aerospace Medicine,the Fourth Military Medical University,Xi’an 710032,Shaanxi Province,China

·AIM:To establish a new method to record visual evoked potential of rats and this method was applied to retinal cone degeneration (RCD) and congenital stationary night blindness (CSNB) rats to see whether it is feasible.·METHODS:After anesthesia,the rats scalp surface was exposed and two stainless screws were implanted at 4mm in front of and 8mm behind *** front one was reference electrode and the latter one was recording *** ground electrode was joined to the *** we recorded VEP of scotopic adaptation and photopic adaptation (The stimulus intensity of light :0.011,0.035,0.11,0.35,1.1 and 3.5cd·s/*** were all overlapped for 100 *** were 2-5minutes intervals between different *** frequency of stimulation was 1Hz and time course was 300 milliseconds).A week later,we recorded the VEP again in the same conditions.·RESULTS:The rats who were implanted with electrodes could live *** they were recorded,there was no disturbance and the waveforms were very clear and *** was no difference between the waveforms recorded by conventional method and those by implanted electrodes while the amplitude of new method was larger than *** could get the same conclusion in RCD and CSNB rats.·CONCLUSION:Since the electrodes can be kept on the scalp for a longer time,we can not only observe dynamic changes of VEP but also observe the long-duration patho-logical changes in the *** the positions of recording and reference electrodes were fixed,the system error can be reduced and the repeatability of experiments increased.·

关键词： visual evoked potential implanted scalp electrode rats

The Single Training Sample Extraction of visual evoked potentials Based on Wavelet Transform

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Chinese Journal of Biomedical Engineering(English Edition) 2007年第4期16卷 170-178页

作者： LIU Fang ZHANG Zhen CHEN Wen-chao QIN Bing Department of Foundation Medical Henan MedicalCollege for Staff and Workers Zhengzhou 451191 China College of Electronic Information Northwestern Polytechnical University Xi＇an 710072 China

Based on the good localization characteristic of the wavelet transform both in time and frequency domain, a de-noising method based on wavelet transform is presented, which can make the extraction of visual evoked potentials in single training sample from the EEG background noise in favor of studying the changes between the single sample response happen. The information is probably related with the different function, appearance and pathologies of the brain. At the same time this method can also be used to remove those signal’s artifacts that do not appear with EP within the same scope of time or frequency. The traditional Fourier filter can hardly attain the similar result. This method is different from other wavelet de-noising methods in which different criteria are employed in choosing wavelet coefficient. It has a biggest virtue of noting the differences among the single training sample and making use of the characteristics of high time frequency resolution to reduce the effect of interference factors to a maximum extent within the time scope that EP appear. The experiment result proves that this method is not restricted by the signal-to-noise ratio of evoked potential and electroencephalograph (EEG) and even can recognize instantaneous event under the condition of lower signal-to-noise ratio, as well as recognize the samples which evoked evident response more easily. Therefore, more evident average evoked response could be achieved by de-nosing the signals obtained through averaging out the samples that can evoke evident responses than de-nosing the average of original signals. In addition, averaging methodology can dramatically reduce the number of record samples needed, thus avoiding the effect of behavior change during the recording process. This methodology pays attention to the differences among single training sample and also accomplishes the extraction of visual evoked potentials from single trainings sample. As a result, system speed and accuracy could

关键词： visual evoked potential signal extraction wavelet transform single training sample