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visit-to-visit Blood Pressure variability Are Associated with an Imbalance between Sympathetic and Parasympathetic Tone in Hypertensive Patients

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Health 2022年第2期14卷 246-253页

作者： Takuzo Hano Yumi Koike Satellite Clinic for Integrative and Anti-Aging Medicine Wakayama Medical University Wakayama Japan Department of Rehabilitation Medicine School of Medicine Wakayama Medical University Wakayama Japan

Greater fluctuations in office blood pressure increase the risk of stroke and blood pressure volatility is an important risk factor for cardiovascular events. Effects of sympathetic and parasympathetic nerve on blood pressure regulation are well known, however, those on visit-to visit variation remains unclear. Aim of this study is to clarify the contribution of sympathetic and parasympathetic balance on blood pressure fluctuation. Methods: We enrolled 23 outpatients with essential hypertension. We measured blood pressure, and pulse rate at clinic 14 times in a row and calculated coefficient of variance (CV) as visit-to-visit variability. The velocity of pupil contraction, miosis (VC) and dilation, mydriasis (VD) was determined from pupillary function test. Results: Systolic blood pressure and diastolic blood pressure were not significantly correlated with VC, VD and VD/VC. Heart rate was not correlated with VC and VD, but significantly correlated with VD/VC. CV of systolic blood pressure, diastolic blood pressure and heart rate were not significantly correlated with VC or VD. Ratio of VD to VC significantly negative correlated with CV of blood pressure, diastolic blood pressure, and heart. Value of VD was significantly correlated with value of VC. Conclusion: visit-to-visit variability of blood pressure and heart rate is not related with sympathetic or parasympathetic tone independently but augmented by the impaired sympathetic and parasympathetic balance.

关键词： visit-to-visit variability Blood Pressure Sympathetic Activity Parasympathetic Activity

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Association of visit-to-visit Variabilities in Metabolic Factors with Chronic Kidney Disease in Chinese Adults Living in Shanghai

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Biomedical and Environmental Sciences 2021年第10期34卷 761-772页

作者： LI Ling WANG Fei XU Min LU Jie Li ZHAO Zhi Yun LI Mian WANG Tian Ge WANG Shuang Yuan BI Yu Fang XU Yu CAI Wei Min NING Guang Department of Clinical Pharmacy and Pharmaceutical Management School of PharmacyFudan UniversityShanghai 201203China Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai National Clinical Research Center for Metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR ChinaShanghai National Center for Translational MedicineRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China

Objective This study aimed to examine the association of visit-to-visit variabilities in metabolic factors with chronic kidney disease(CKD)in Shanghai community *** We used data from a cohort study of community residents who participated in three examinations in 2008,2009,and 2013,*** plasma glucose(FPG)level,blood pressure(BP),and lipid levels were determined in 2,109 participants at all three visits,and CKD was evaluated between the second and the third ***-to-visit variabilities in metabolic factors were described by coefficients of variation(CV)at three visits.A variability score was calculated by adding the numbers of metabolic factors with a high variability defined as the highest quartile of *** was defined as the estimated glomerular filtration ratevariability *** with participants with score 0,participants with scores of 1,2,and 3 were associated with 58%(OR=1.58,95%CI 1.08–2.32),121%(OR=2.21,95%CI 1.40–3.49),and 548%(OR=6.48,95%CI 3.18–13.21)higher risks of CKD,*** The visit-to-visit variabilities in metabolic factors were significantly associated with the risks of CKD in Shanghai community residents.

关键词： Chronic kidney disease Cohort Metabolic factor visit-to-visit variability

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