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Effects of wavelength,beam type and size on cerebral low-level laser therapy by a Monte Carlo study on visible chinese human

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Journal of Innovative Optical Health Sciences 2015年第1期8卷 68-76页

作者： Ting Li Yue Zhao Yunlong Sun Kai Li School of Microelectronics&Solid-State Electronics Biomedical Engineering University of Electronic Science&Technology of China Chengdu 610054P.R.China

Low-level laser therapy(LLLT)has been clinically utilized for many indications in medicine requiring protection from el/issue death,stimulation of healing and repair of injuries,pain reduction,swelling and ***,the use of LLLT to treat stroke,traumnatic brain injury and cognitive dysfunction are attracting growing *** infrared light is capable of penetrating into the cerebral cortex,allowing noninvasive treatments to be caried out with few treatment-related adverse *** of LLLT treatment flfect is a crucial isse of this field;however,only a few experimental tests on mice for wavelength selection have been *** addressed this ssue by low-ost,straightforward and quantitative comparisons on light dosage distribution within visible chinese human head by Monte Carlo modeling of near infrared light *** selection in wavelength,beam type and size were given based on comparisons among frequently used setups(ie,wavelengths:660,810 and 980 nm;beam type:Gaussian and flat beamn;beam diameter:2,4 and 6 cm).This study provided an fficient way for guiding the optimization of LLLT setup and selection on wavelength,beam type and size for clinical brain LLLT.

关键词： Low level laser therapy visible chinese human Monte Carlo simulation beamn wavelength

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Effect of head model on Monte Carlo modeling of spatial sensitivity distribution for functional near-infrared spectroscopy

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Journal of Innovative Optical Health Sciences 2015年第5期8卷 77-85页

作者： Ting Li Yan Li Yunlong Sun Meixue Duan Liyuan Peng State Key Lab Elect Thin Film&Integrated Device and Department of Biomedical Engineering University of Electronic Science&Technology of ChinaChengdu 610054P.R.China Design Department No.2 Avic Beijing Keeven Aviation Instrument Co.LtdBeijing 100086P.R.China

Modeling Light propagation within human head to deduce spatial sensitivity distribution(SSD)is important for Near-infrared spectroscopy(NIRS)/imaging(NIRI)and diffuse correlation *** of head models have been used on this issue,including layered head model,artificial simplified head model,MRI slices described head model,and visible human head ***,visible chinese human(VCH)head model is considered to be a most faithful presentation of anatomical structure,and has been highlighted to be employed in modeling light ***,it is not practical for all researchers to use VCH head models and actually increasing number of people are using magnet resonance imaging(MRI)head ***,all the above head models were simulated and compared,and we focused on the effect of using di®erent head models on predictions of *** results were in line with the previous reports on the effect of cerebral cortex folding ***,the in fluence on SSD increases with thefidelity of head *** surprisingly,the SSD percentages in scalp and gray matter(region of interest)in MRI head model were found to be 80%and 125%higher than in VCH head *** head models induced nonignorable discrepancy in SSD estimation when compared with VCH head *** study,as we believe,is the first to focus on comparison among full serials of head model on estimating SSD,and provided quantitative evidence for MRI head model users to calibrate their SSD estimation.

关键词： visible chinese human functional near-infrared spectroscopy Monte Carlo simulation head model spatial sensitivity distribution

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