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Prognostic factors for overall survival in prostate cancer patients with different site-specific visceral metastases: A study of 1358patients

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World Journal of Clinical Cases 2020年第1期8卷 54-67页

作者： Peng-Fei Cui Xiao-Feng Cong Feng Gao Jia-Xin Yin Zi-Ru Niu Song-Chen Zhao Zi-Ling Liu Cancer Center the First Hospital of Jilin University

BACKGROUND Distant metastasis,particularly visceral metastasis(VM),represents an important negative prognostic factor for prostate cancer(PCa)***,due to the lower rate of occurrence of VM,studies on these patients are relatively ***,studies focusing on prognostic factors associated with PCa patients with VM are highly *** To investigate the prognostic factors for overall survival(OS)in PCa patients with lung,brain,and liver metastases,respectively,and evaluate the impact of site-specific and number-specific VM on *** Data on PCa patients with VM were extracted from the Surveillance,Epidemiology,and End Results database between 2010 and *** and multivariate Cox regression analyses were used to analyze the association between clinicopathological characteristics and survival of patients with different site-specific ***-Meier analyses and Log-rank tests were performed to analyze the differences among the *** A total of 1358 PCa patients with site-specific VM were identified from 2010 to *** age(>70 years)(P8)(P70 years)(P=0.010)and higher Gleason score(>8)(P=0.001)were associated with shorter OS in PCa patients with liver *** patients with isolated lung metastases exhibited significantly better survival outcomes compared with PCa patients with other single sites of VM(P<0.001).PCa patients with a single site of VM exhibited a superior OS compared with PCa patients with multiple sites of VM(P<0.001).CONCLUSION This is the first Surveillance,Epidemiology,and End Results-based study to determine prognostic factors affecting OS in PCa patients with different si

关键词： Prognostic factors Overall survival Prostate cancer visceral metastases

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