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Effect of methylprednisolone therapy on hospital stay and viral clearance in patients with moderate COVID-19

Infectious Medicine 2022年第4期1卷 236-244页

作者： Xiaoyan Li Xin Yuan Zhe Xu Lei Huang Lei Shi Xuechun Lu Fu-Sheng Wang Junliang Fu Medical School of Chinese PLA BeijingChina Senior Department of Infectious Diseases The Fifth Medical Center of Chinese PLA General HospitalBeijingChina National Clinical Research Center for Infectious Diseases BeijingChina Department of Hematology the Second Medical Center of Chinese PLA General HospitalBeijingChina

Background:The benefits and harms of methylprednisolone treatment in patients with moderate coronavirus disease 2019(COVID-19)remain controversial.In this study,we investigated the effect of methylprednisolone on mortality rate,viral clearance,and hospitalization stay in patients with moderate COVID-19.Methods:This retrospective study included 4827 patients admitted to Wuhan Huoshenshan and Wuhan Guanggu hospitals from February to March 2020 diagnosed with COVID-19 pneumonia.The participants’epidemiological and demographic data,comorbidities,laboratory test results,treatments,outcomes,and vital clinical time points were extracted from electronic medical records.The primary outcome was in-hospital death;secondary outcomes were time from admission to viral clearance and hospital stay.Univariate and multivariate logistic or linear regression analysis were used to assess the roles of methylprednisolone in different outcomes.The propensity score matching(PSM)method was used to control for confounding factors.Results:A total of 1320 patients were included in this study,of whom 100 received methylprednisolone.Overall,in-hospital mortality was 0.91%(12/1320);the 12 patients who died were all in the methylprednisolone group,though multivariate logistic regression analysis showed methylprednisolone treatment was not a risk factor for in-hospital death in moderate patients before or after adjustment for confounders by PSM.Methylprednisolone treatment was correlated with longer length from admission to viral clearance time and hospital stay before and after adjustment for confounders.Conclusions:Methylprednisolone therapy was not associated with increased in-hospital mortality but with delayed viral clearance and extended hospital stay in moderate COVID-19 patients.

关键词： COVID-19 Hospital stay In-hospital death Moderate viral clearance

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A Physician Suffering from COVID-19 with Multiple Co-Morbidities Have Delayed viral clearance: A Case Report from Bangladesh

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Advances in Infectious Diseases 2020年第3期10卷 94-100页

作者： Md. Reaz Uddin Chowdhury Kazi Shanzida Akter Sahedul Islam Bhuiyan Md. Khalilur Rahman Khabir Bimal Chandra Das Muhammad Anwarul Kabir Abdul Malek Ukil Medical College Noakhali Bangladesh Dedicated COVID-19 Hospital-Trauma Center Feni Bangladesh Brahmanbaria Medical College Brahmanbaria Bangladesh 250 Bed District Sadar Hospital Feni Bangladesh

Background: Novel corona virus (SARS-Coronavirus-2 SARS-CoV-2) which emerged in China has spread to multiple countries rapidly. Little information is known about delayed viral clearance in mild to moderate COVID-19 pa-tients. As it is highly contagious, health care workers including physicians are high risk of being infected in hospital care. Case Report: A 37 years old Bangladeshi physician working in a paediatric unit of a medical college hos-pital with multiple co-morbidities, hypertension, diagnosed axial spondy-loarthropathy (ankylosing spondylitis) taking disease modifying anti rheu-matic drugs— DMARDs (Salfasalazine) from 2016 till now, chronic persis-tent bronchial asthma on medication developed sore throat, increasing breathlessness and cough admitted to his own hospital on 22 April, 2020. He had a history of contact with a relapse nephrotic syndrome (glomerulone-phritis) patient admitted with severe respiratory distress later confirmed as COVID-19 following RT PCR test on 14 April, 2020. After 3 days of contact with the patient, the physician also developed the symptoms mentioned above. The RT PCR test result of the physician came positive on 18 April, 2020. The physician primarily taken only azithromycin 500 mg once daily along with other regular drugs. On 5, 12 and 18 May, 2020, his sample was taken for re-test and came positive subsequently. After that he started Iver-mectin (0.15 mg/kg) once daily for 3 days and doxycycline 100 mg BD for 7 days. He gave samples again on 27 and 29 May, 2020 which were came nega-tive after 39 days. On full recovery he was discharged from hospital on day 40. We choose the patient because presence of co-morbidities may be asso-ciated with delayed viral clearance and physicians with co-morbidities working in a hospital have high risk of being infected.

关键词： Physician Co-Morbidities viral clearance COVID-19 Case Report Bangla-desh

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