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NSAID-induced deleterious effects on the proximal and mid small bowel in seronegative spondyloarthropathy patients

World Journal of Gastroenterology 2011年第8期17卷 1030-1035页

作者： Mihai Rimba■ Mǎdǎlina Marinescu Mihail Radu Voiosu Cristian Rǎsvan Bǎicu■ Simona Caraiola Adriana Nicolau Doina Ni■escu Georgeta Camelia Badea Magda Ileana Parvu Department of Gastroenterology "N.Gh.Lupu" Clinic of Inter-nal Medicine "Carol Davila" University of Medicine and Phar-macy Colentina Clinical Hospital Department of Internal Medicine "N.Gh.Lupu" Clinic of Internal Medicine "Carol Davila" University of Medicine and Pharmacy Colen-tina Clinical Hospital Department of Rheumatology Colentina Clinical Hospital

AIM:To investigate the small bowel of seronegative spondyloarthropathy(SpA) patients in order to ascertain the presence of mucosal ***:Between January 2008 and June 2010,54 consecutive patients were enrolled and submitted to avideo capsule endoscopy(VCE) *** demographic data were taken,as well as the history of non-steroidal anti-inflammatory drug(NSAID) *** reading each VCE recording,a capsule endoscopy scoring index for small bowel mucosal inflammatory change(Lewis score) was *** analysis of the data was ***:The Lewis score for the whole cohort was *** was higher in the NSAID consumption subgroup(P = 0.036).The difference in Lewis score between NSAID users and non-users was reproduced for the first and second proximal tertiles of the small bowel,but not for its distal third(P values of 0.036,0.001 and 0.18,respectively).There was no statistical significant difference between the groups with regard to age or sex of the ***:The intestinal inflammatory involvement of SpA patients is more prominent in NSAID users for the proximal/mid small bowel,but not for its distal part.

关键词： videocapsule endoscopy Lewis score Non-steroidal anti-inflammatory drugs Small bowel mucosal injury Spondyloarthropathy

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