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Chinese Chemical Letters 2019年第8期30卷 1538-1540页

作者： Haiyu Sun Guangmiao Wu Xingang Xie State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University

The AC bicyclic skeleton of daphniyunnine B with the required 3 stereocenters(C4,C5 and C8)was accomplished in a concise route which featured two Claisen-type rearrangement reactions to construct the required vicinal all carbon quaternary stereocenters(C5 and C8)and an intramolecular iodocyclization reaction to assemble the cis-confused bicyclic lactam.

关键词： Daphniyunnine B vicinal quaternary stereocenters Claisen rearrangement Intramolecular iodo-amidation reaction

Small molecule fluorescent probes of protein vicinal dithiols

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Chinese Chemical Letters 2019年第10期30卷 1704-1716页

作者： Guodong Hu Huiyi Jia Lanning Zhao Dong-Hyung Cho Jianguo Fang State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou 730000China School of Life Sciences Kyungpook National UniversityDaegu 41566Republic of Korea

The vicinal dithiol motif is widely present in proteins, and is critical for proteins’ structures and *** recent years, a variety of fluorescent probes with high specificity and outstanding optical properties for sensing protein vicinal dithiols have been developed. In this review, we summarized the fluorescent probes of protein vicinal dithiols in literature. These probes are classified into four types based on their acceptor sites, i.e., biarsenical probes, monoarsenical probes, dimaleimide probes and diacrylate *** analyzing the properties of different probes, we expect that this review would help readers further understand the structural factors of these probes and provide the design strategy for novel fluorescent probes with improved properties.

关键词： Fluorescent probe Protein vicinal dithiols Arsenical probe Thiol redox Reaction-based probe

Regioselective aminohalogenation of β-nitrostyrenes using NCS and NBS as nitrogen/halogen sources

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Science China Chemistry 2010年第1期53卷 140-146页

作者： ZHI SanJun1,2,SUN Hao2,LIN Chen2,ZHANG GuangQian2,LI GuiGen4 & PAN Yi2,3 1 Department of Chemistry,Huaiyin Normal University,Huai’an 221003,China 2 School of Chemistry and Chemical Engineering,Nanjing University,Nanjing 210093,China 3 State Key Lab of Coordination Chemistry,Nanjing University,Nanjing 210093,China 4 Department of Chemistry and Biochemistry,Texas Tech University,Lubbock,Texas 79409-1061,USA 1. Department of Chemistry Huaiyin Normal University Huai’an 221003 China2. School of Chemistry and Chemical Engineering Nanjing University Nanjing 210093 China4. Department of Chemistry and Biochemistry Texas Tech University Lubbock Texas 79409-1061 USA3. State Key Lab of Coordination Chemistry Nanjing University Nanjing 210093 China

Aminohalogenation reaction of β-nitrostyrenes with N-halosuccinimides(N-chloro and N-bromosuccinimides) has been successfully conducted by using nickel acetate as a catalyst in the presence of potassium carbonate and succinimide as *** reaction was easily performed at room temperature under nitrogen gas protection to give dihalorinaed haloamino products in good to excellent yields(60%-98%).The structure has been confirmed by X-ray crystal structure analysis.

关键词： aminohalogenation vicinal haloamines β-nitrostyrenes NBS NCS

Quinine-derived thiourea promoted enantioselective Michael addition reactions of 3-substituted phthalides to maleimides

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Science China Chemistry 2019年第5期62卷 649-652页

作者： Jie Wang Xin Li Jin-Pei Cheng State Key Laboratory of Elemento-Organic Chemistry Collaborative Innovation Center of Chemical Science and EngineeringCollege of ChemistryNankai University

A highly diastereoselective and enantioselective Michael addition/desymmetrization reaction of maleimides with prochiral 3-substituted phthalides catalyzed by quinine-derived bifunctional thiourea was realized. A broad range of the 3,3′-disubstituted phthalides bearing vicinal quaternary-tertiary stereogenic centers were synthesized in moderate to good yields(up to 96%) with high diastereoselectivities(up to >19:1 dr) and enantioselectivities(up to 96:4 er).

关键词： michael addition 3,3′-disubstituted phthalides vicinal quaternary-tertiary stereogenic centers