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Photoelectrochemical Immunosensor Array Based on Thioglycolic Acid Capped CdS Quantum Dots for Multiplexed Detection of veterinary drug Residues

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Chinese Journal of Chemistry 2012年第5期30卷 1168-1176页

作者：肖飞赖彦君张苧丹白静鲜跃仲金利通 Department of Chemistry East China Normal UniversityShanghai 200062China

A photoelectrochemical immunosensor based on multi-electrode array was developed for simultaneous and sen- sitive determination of veterinary drug residues. In this system, poly（dimethyldiallylammonium chloride）（PDDA）, Au nanoparticles （Au NPs） and thioglycolic acid （TGA）-capped CdS quantum dots （QDs） were layer-by-layer as- sembled onto the home-made Au electrode array. The assembling process of the （CdS/PDDA/Au NPs/PDDA）, mul- tilayer was characterized by electrochemical impedance spectroscopy. And then the antibodies for clenbuterol （CB）, ractopamine （RAC） and chloramphenicol （CAP） were covalently immobilized onto the Au electrode array by 1-ethyl-3-（3-dimethylaminopropyl） carbodiimide （EDC） coupling reaction, respectively. The concentrations of CB, RAC and CAP were measured based on the photoelectrochemical effects of CdS QDs. Under the optimal conditions the limits of detection （LOD） for CB, RAC and CAP were 25, 50 and 2.2 pg/mL （3a）, respectively, with acceptable recovery over the range of 95.40%--105.5% in pig liver samples. All results indicate that the immunosensor array system has potential application for practical, effective and high throughput analysis of veterinary drugs residues.

关键词： CdS quantum dots photoelectrochemical immunosensor array veterinary drug

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Development and validation of a multiclass method for the quantification of 42 veterinary drugs residues in honey and royal jelly by liquid chromatography-tandem mass spectrometry

Development and validation of a multiclass method for the qu...

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二十一世纪第二届全国蜂业科技与蜂产业发展大会

作者： Yue Jin Jinzhen Zhang Wen Zhao Wenwen Zhang Lin Wang 周金慧 Yi Li Institute of Apicultural Research Chinese Academy of Agricultural Sciences Bee Product Quality Supervision and Testing Center Ministry of Agriculture Laboratory of Risk Assessment for Quality and Safety of Bee Products Ministry of Agriculture

The aim of this study was to develop an analytical method for the analysis of a wide range of veterinary drugs in honey and royal jelly.A modified sample preparation procedure based on the quick,easy,cheap,effective,rugged and safe（QuEChERS） method was developed,followed by liquid chromatography tandem mass *** of thesingle sample preparation method for analysisof 42 veterinary drugs becomes more valuable because honey and royal jelly belong to completely different complex *** main advantage of the proposed methodis its ability to identify and quantify 42 veterinary drugs with higher sensitivity than reference methods of *** work has shown that the reported method was demonstrated to be convenient and reliable for the quick monitoring of veterinary drugs in honey and royal jelly samples.

关键词： Honey Royal jelly Multiclass residue QuEChERS HPLC-MS/MS veterinary drug

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电子束辐照下兽药残留的降解

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分析测试学报 2007年第Z1期26卷 283-284页

作者：杨成对宋莉晖陈培榕清华大学化学系北京100084

Clenbuterol and some kinds of antibiotic are banned strictly using as veterinary drug by Europe Union,America and Chinese Agriculture *** irradiation can change difficultly degraded pollutants into easily degraded ***,SC and AOZ can be degraded more than 95% when the irradiation dosage was greater than *** results indicated such irradiation method is applicable.

关键词： Degrade veterinary drug Electronic bean irradiation

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Total Synthesis and High Performance Liquid Chromatography Analysis of Phenylethanolamine A

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Chemical Research in Chinese Universities 2017年第4期33卷 598-602页

作者： WANG Tongtong SONG Yinqing WANG Min TANG Xiaoyan ZHOU Jian YANG Mengrui Institute of Quality Standard and Testing Technology for Agro-products Chinese Academy of Agricultural Sciences Beoing 100081 P. R. China Key Laboratory of Agro-food Safety and Quality Ministry of Agriculture Beijing 100081 P. R. China

A simple, effective and reliable synthetic method was developed to construct beta-agonist phenylethano- lamine A（PEAA） in good yield with 4-nitrobenzyl bromide as the starting material, which underwent SN2 reaction with ethyl acetoacetate, followed by hydrolysis with concentrated HC1 and amination by Lettkart reaction to furnish 4-（4-nitrophenyl）butan-2-amine（A）. A one-pot reaction was studied to construct PEAA skeleton and reduced carbonyl with KBH4, the conditions were optimized, including reaction temperature, reaction time, solvent and the molar ratio of 2-bromo-l-（4-methoxyphenyl）ethanone（B） to A. Meanwhile, a reliable and practical high performance liquid chromography（HPLC） method with UV detector was developed after screening wavelength, chromatographic column and optimization of mobile phase. The optimal conditions of detecting PEAA were water（0.1% formic acid and 0.1% triethylamine）-methanol（volume ratio 44：56） at 278 nm with plus-C^8 column. The above synthetic method would be used to synthesize standard reference materials and advance extensive application of analytical method. In order to ensure food safety and safeguard human health, the analytical method might be used as a standard method in detection and supervision of PEAA.

关键词： veterinary drug Phenylethanolamme A High performance liquid chromography(HPLC)

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Multiclass screening of ＞ 200 pharmaceutical and other residues in aquatic foods by ultrahigh performance liquid chromatography-quadrupole-Orbitrap mass spectrometer

Multiclass screening of ＞ 200 pharmaceutical and other resi...

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中国化学会第十三届全国分析化学年会

作者： Cong Kong Yang Wang Guang-Xin Yang Yong-Fu Shi Xiao-Yi Lou Hui-Juan Yu Key Laboratory of East China Sea Fishery Resources Exploitation Ministry of Agriculture East China Sea Fisheries Research Institute Chinese Academy of Fishery Sciences

A quick screening method of ＞200 pharmaceutical and other residues in aquatic foods based on ultrahigh performance liquid chromatography-quadrupole-Orbitrap mass spectrometer system（UHPLC-Q/Orbitrap MS） was established. In this method, after the addition of 200 μL of 1 M EDTA-Na2, 2 g homogenates were extracted successively with 10 mL of acetonitrile and 10 mL of ethyl acetate. The extracts were combined and dried under nitrogen flow, and redissolved in 0.1% formic acid in acetonitrile/water（4:6, v/v） for analysis. The prepared samples were analyzed through UHPLC-Q/Orbitrap MS system, at Full MS/ddMS2（full-scan data-dependent MS/MS） mode. Identification was performed through the comparison of the sample data with the database for standard chemicals, including the retention time, precursor ion, product ions and isotope pattern for all 206 compounds. Five different aquatic food matrices（carp, shrimp, crab, eel, and mussel） spiked with the analytes at 1, 10, and 50 ng/g were evaluated to assess recoveries, precision, matrix effects, stability, and detection limits using the method. UHPLC analyses were 25 min, and 178-200 analytes met identification criteria at 50 ng/g depending on the matrix. Furthermore, practical application of this method for real samples displayed strong screening capability

关键词： veterinary drug Aquatic Food Screening Orbitrap Pesticide Contaminant Residue

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