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Therapeutic Benefits of vernonia amygdalina in the Treatment of Inflammation and Its Associated Diseases

Clinical Complementary Medicine and Pharmacology 2024年第1期4卷 44-53页

作者： Du-Bois Asante Gideon Akuamoah Wiafe Korantema Mawuena Tsegah Nelson Kwabla Domey Department of Forensic Sciences School of Biological SciencesCollege of Agriculture and Natural SciencesUniversity of Cape CoastPMBCape CoastGhana Department of Biomedical Sciences School of Allied Health SciencesCollege Health and Allied SciencesUniversity of Cape CoastPMBCape CoastGhana School of Medical Sciences College Health and Allied SciencesUniversity of Cape CoastPMBCape CoastGhana

Background:In the presence of a stimulus that disrupts homeostasis,the body elicits a response known as *** inflammatory response is expected to restore the normal functioning of the body and initiate healing where ***,the persistent activity of acute inflammation results in chronic inflammation which causes adverse consequences associated with diseases such as diabetes and *** traditional medical practice,vernonia amygdalina is used to treat several ailments such as malaria,fever,diabetes,and inflammatory conditions such as those related to pain and ***:This review seeks to explore and discuss the therapeutic benefits of *** in the treatment of inflammation and its associated ***:We reviewed the scientific literature indexed in PubMed,ScienceDirect and Springer,and discussed the reported anti-inflammatory properties of *** and its curative activity in inflammation-associated ***:A total of 30 published articles were identified describing the therapeutic effect of *** in predominately experimental *** anti-inflammatory properties of *** have been linked to the presence of bioactive phytoconstituents predominantly present in the leaves of the ***:Multiple studies have demonstrated that the aqueous and ethanolic extracts of *** can inhibit the production of proinflammatory cytokines and enzymes in inflammatory cells,reducing inflammation and its associated *** critically appraise the current evidence,and discuss the potential use of this medicinal plant in the treatment of inflammatory conditions.

关键词： vernonia amygdalina Inflammation Cytokines Wound healing Analgesic Antipyretic

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Phytochemical screening and antibacterial activities of Momordica charantia and vernonia amygdalina extracts on some selected enteric isolates

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TMR Modern Herbal Medicine 2024年第1期7卷 11-18页

作者： Seyi-Samson Enitan Zaynab-Aderonke Ojubanire Temiloluwa-Femi Oyedele Nwachi-Idume Ogbonna Adekunle-Totoola Adeyemi Jamiu-Monsur Olalekan Ayomide-Oluwatobiloba Okuneye Department of Medical Laboratory Science Babcock University Ilishan-RemoOgun state 121103Nigeria Department of Medical Microbiology Babcock University Teaching HospitalIlishan-RemoOgun State 121103Nigeria Department of Education Medical Laboratory Science Council of NigeriaFCT-Abuja 900110Nigeria Clinical Laboratory Department Central Medical Diagnostic CentreIbadan 200113Nigeria

Background:This research focuses on herbal medicine,an ancient healthcare practice,exploring the antibacterial attributes of fresh and dried leaf extracts from Momordica charantia(commonly known as Bitter melon)and vernonia amygdalina(Bitter leaf).The study specifically investigates their effects on different bacterial strains associated with ***:Four enteric bacterial isolates-Klebsiella pneumoniae,Salmonella typhi,Escherichia coli,and Proteus mirabilis-were obtained from the Medical Laboratory Unit at Babcock University Teaching Hospital in Ilishan-Remo,Ogun *** screening and antibacterial testing were conducted using standard biochemical techniques and the Punch-hole agar diffusion method,***:Qualitative phytochemical screening of the plant extracts revealed the presence of flavonoids,glycosides,and saponin in both plants,excluding *** were identified only in vernonia *** these phytochemicals,neither plant displayed inhibitory effects on the tested bacterial isolates(Escherichia coli,Proteus mirabilis,Klebsiella pneumoniae,and Salmonella typhi)when tested individually or in ***,combining the fresh and dried leaf extracts of Momordica charantia and vernonia amygdalina with a standard drug resulted in smaller mean zone diameters of inhibition(Escherichia coli range:14 mm–16 mm,Proteus mirabilis range:31 mm–35 mm,Klebsiella pneumoniae range:13 mm–22 mm,and Salmonella typhi range:35 mm–38 mm)compared to the drug tested alone(16 mm–45 mm).Conclusion:Despite previous indications of antibacterial properties in various extracts of *** and *** leaves,our study presents contradictory results,prompting the need for further investigation despite the presence of significant phytochemicals.

关键词： phytochemical screening herbal medicine Momordica charantia vernonia amygdalina enteric isolates

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Immunological effect of aqueous extract of vernonia amygdalina and a known immune booster called immunace and their admixtures on HIV/AIDS clients:a comparative study

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Asian Pacific Journal of Tropical Biomedicine 2012年第3期2卷 181-184页

作者： Momoh MA Muhamed U Agboke AA Akpabio EI Uduma Eke Osonwa Department of Pharmaceutics University of Nigeria Nsukka Department of Chemistry Ahmadu Bello University Zaria Department of Pharmaceutics and Pharmaceutical Technology University of Uyo

Objective:To investigate the immunological effect of vernonia amygdalina(***) leaf extract and immunace on HIV infected patients taking highly active antiretrwiral therapy. Methods:Fresh *** leaves were collected within Nsukka area in Enugu *** leaves were rinsed with distilled *** handful of cleaned fresh leaves were soaked in 200 mL water and squeezed gently by hand to a *** were divided into four groups and each group was given different *** took the medication for four *** immune effect was tested against marketed immune booster in some retroviral ***:The mean absolute CD4 count was increased in the client who took the extract or *** the clients who took both the extract and supplement had a greater increase in the CD4 *** increased CD4 was significant as compared with the control group(P<0.05).The skin rashes were also improved in the entire ***:It can be concluded that the aqueous extract of *** and immunace or both have immunological effect on HIV infected patients. Therefore,we suggest that the *** extract or immunace or both could be used as adjuvant in the management of HIV/AIDS clients.

关键词： CD4^(+) cell Immune vernonia amygdalina HIV/AIDS Antiretroviral therapy Immunological effect Immunace®

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The Phytochemistry, Ethnobotanical, and Pharmacological Potentials of the Medicinal Plant-vernonia amygdalina L. (bitter Leaf)

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Clinical Complementary Medicine and Pharmacology 2021年第1期1卷 41-55页

作者： Eziuche A.Ugbogu Okezie Emmanuel Emmanuel D.Dike Grace O.Agi Ositadimma C.Ugbogu Chibuike Ibe Emeka J.Iweala Department of Biochemistry Abia State UniversityPMB 2000UturuAbia StateNigeria Department of Nutrition Sheffield Hallam UniversityUnited Kingdom Department of Microbiology Abia State UniversityPMB 2000UturuAbia StateNigeria Department of Biochemistry Covenant UniversityPMB 1023OtaOgun StateNigeria

Background:vernonia amygdalina is traditionally used to treat a variety of diseases including diarrhoea,fungal and bacterial infections,inflammation,cancer,diabetes,and its squeezed juice can be applied on ***:This study reviewed the phytochemistry,ethnopharmacological,and pharmacological potentials of ***:Literature search of relevant papers(1994-2021)were performed using ScienceDirect,Springer,Wiley and PubMed *** this review study,only publications written in English were ***:The bioactive compounds extracted from *** includes 6𝛽,10𝛽,14𝛽trimethylheptadecan-15𝛼-olyl-15-O-𝛽-D-glucopyranosyl-1,5𝛽olide,glucuronolactone,11𝛼-hydroxyurs-5,12-dien-28-oic acid-3𝛼,25-olide,10-geranilanyl-O-𝛽-D-xyloside,1-heneicosenol O-𝛽-D-glucopyranoside,apigenin,luteolin(3´,4´,5,7tetrahydroxyflavone),vernolide,hydroxyvernolide,3′-deoxyvernodalol,vernodalol,diterpene(ingenol-3-angelate),vernomygdin,4-methylumbelliferone,cephantharin,cryptolepine,isocryptolepine,neocryptolepine,courmarins,vernolepin,and *** in vivo and in vitro studies revealed that *** and its bioactive components possess pharmacological activities such as antioxidant,anti-inflammatory,anticancer,antimicrobial,hepatoprotective,antidiarrheal,anti-diabetic,and neuroprotective ***:This review demonstrated that *** possess therapeutic effects against a wide variety of *** efficacy of *** in ameliorating diseases is attributed to its antioxidant activity and ability to improve the antioxidant *** the vast pharmacological activities of ***,more human clinical trials are needed to identify effective and safe doses for treatment of various diseases.

关键词： vernonia amygdalina Pharmacological activities Phytochemicals Traditional uses

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Novel Stigmastane-type steroids from the twigs of vernonia amygdalina

Novel Stigmastane-type steroids from the twigs of Vernonia a...

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中国化学会第十二届全国天然有机化学学术会议

作者： Xiangzhong Liu Wenjing Tian Qiannan Xu Mi Zhou Dequan Zeng Shuo Gao Daren Qiu Ting Lin Haifeng Chen School of Pharmaceutical Sciences Xiamen University

vernonia amygdalina Del.(compositae) is widely distributed in tropical Africa with a well-known name "bitter leaf" due to its bitter taste.V amygdalina,as a member of vernonia genus,has been traditionally used to cure diseases like malaria,diabetes,pneumonia,jaundice,anaemia,stomach problems,andascariasis and so on .In this study,eleven novel stigmastane-type steroids,including one aglycone(1) and ten glycosides(2-11),along with three known homologues(12-14) were isolated from the twigs of V *** 1-11 featured a stigmastane-type steroid skeleton with a unique conjugated Δ7,9(11)) diene segment and highly oxygenated side chains with a γ-lactone or α,β-unsaturation five-membered lactone *** structures of compounds 1-11 and their absolute configurations were unambiguously elucidated by HR-ESI-MS,extensive NMR spectroscopy,in situ dimolybdenum CD method,modified Mosher’s Method,quantum chemical calculation of ECD and CD comparison methods on basis of their biogenetic ***,all the isolates were investigated for their RXRa transcriptional activities and their effects on NF-κB signaling pathway and cytotoxicity towards MCF-7 cells were also evaluated.

关键词： vernonia amygdalina stigmastane-type steroids structural elucidation bioactivity evaluation

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