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Journal of Geriatric Cardiology 2014年第4期11卷 357-362页

作者： Rong-Zeng DU Jun QIAN Jun WU Yi LIANG Guang-Hua CHEN Tao SUN Ye ZHOU Yang ZHAO Jin-Chuan YAN Department of Cardiology Affiliated Hospital of Jiangsu University Zhenjiang 212001 Jiangsu Province China

A 54-year-old female patient with congenital heart disease had a persistent complete left bundle branch block three months after closure by an Amplatzer ventricular septal defect occluder. Nine months later, the patient suffered from chest distress, palpitation, and sweating at daily activities, and her 6-min walk distance decreased significantly （155 m）. Her echocardiography showed increased left ventricular end-diastolic diameter with left ventricular ejection fraction of 37%. Her symptoms reduced significantly one week after received cardiac resynchronization therapy. She had no symptoms at daily activities, and her echo showed left ventricular ejection fraction of 46%and 53%. Moreover, left ventricular end-diastolic diameter decreased 6 and 10 months after cardiac resynchronization therapy, and 6-min walk dis-tance remarkably increased. This case demonstrated that persistent complete left bundle branch block for nine months after transcatheter closure with ventricular septal defect Amplatzer occluder could lead to left ventricular enlargement and a significant decrease in left ventricular systolic function. Cardiac resynchronization therapy decreased left ventricular end-diastolic diameter and increased left ventricular ejection fraction, thereby improving the patient’s heart functions.

关键词： ventricular septal defect Amplatzer occluder Left bundle branch block Heart failure Cardiac resynchronization therapy

Mortality Rates of ventricular septal defect for Children in Kazakhstan: Spatio-Temporal Epidemiological Appraisal

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Congenital Heart Disease 2023年第4期18卷 447-459页

作者： Akkerbez Adilbekova Shukhrat Marassulov Bakhytzhan Nurkeev Saken Kozhakhmetov Aikorkem Badambekova Pediatric Cardiac Surgery Department National Scientific Medical CenterAstana CityRepublic of Kazakhstan Department of Surgical Diseases with Courses in Cardiothoracic Surgery and Maxillofacial Surgery Аstana Medical UniversityAstana CityRepublic of Kazakhstan Faculty of General Medicine Аstana Medical UniversityAstana CityRepublic of Kazakhstan

Objective: The aim is to study the trends in ventricular septal defect (VSD) mortality in children in ***: The retrospective study was done for the period 2011–2020. Descriptive and analytical methods of epidemiologywere applied. The universally acknowledged methodology used in sanitary statistics is used to calculatethe extensive, crude, and age-specific mortality rates. Results: Kazakhstan is thought to be seeing an increase inmortality from VSDs in children. As a result, this study for the years 2011 to 2020 was conducted to retrospectivelyassess data from the central registration of the Bureau of National Statistics that was available throughoutthe nation. Age-standardized mortality data were obtained and compared between age categories. It was shownthat 507 children died from this condition throughout the time period under study. The average annual standardizedmortality rate was 1.88 per 100,000 population and tended to decrease over time. The peak of mortality wasnoted at the age of up to 1 year, namely the neonatal period. Cartogram mortality rates were calculated usingstandardized indicators. Additionally, age-sex variations were taken into account when performing all ***: In recent years, the death rate from VSD has declined from 1.5 to 0.6 per 100,000 people, withthe trend remaining constant (T = 1.4%, R^(2) = 0.5825). The analysis of mortality trends related to VSD is crucial inboth theoretical and practical aspects, as it enables early detection and treatment of VSDs. The findings of thisstudy will be valuable to public health authorities in developing a strategy to treat VSDs effectively.

关键词： ventricular septal defect children mortality geographical variation kazakhstan

Morphology and Function of the Aortic Valve after Transcatheter Closure of ventricular septal defect with Aortic Valve Prolapse

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Congenital Heart Disease 2021年第5期16卷 519-528页

作者： Wenqian Zhang Chaojie Wang Lingmei Zhou Junjie Li Jijun Shi Yumei Xie Mingyang Qian Shushui Wang Zhiwei Zhang Graduate School The Second School of Clinical MedicineSouthern Medical UniversityGuangzhouChina Department of Cardiac Pediatrics Guangdong Provincial Cardiovascular InstituteGuangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhouChina Department of Cardiovascular Surgery Guangdong Cardiovascular InstituteGuangdong Provincial General HospitalGuangdong Academy of Medical SciencesGuangzhouChina School of Medicine South China University of TechnologyGuangzhouChina

Objective:This study aims to evaluate the morphology and function of the aortic valve after transcatheter closure of ventricular septal defect(VSD)with aortic valve prolapse(AVP)abased on clinical and radiological ***:From January 2013 to November 2014,164 consecutive patients(97 males,59.1%)with VSD and AVP were treated by transcatheter *** patients were divided into the mild AVP group(n=63),moderate AVP group(n=89)and severe AVP group(n=12).The clinical and radiological outcomes of these patients were analyzed ***:In total,146(89.0%)patients were successfully treated with VSD occluders,including 59/63(93.7%)with mild AVP,80/89(89.9%)with moderate AVP and 7/12(58.3%)with severe *** degree of AVP was ameliorated or disappeared in 39(26.7%)patients,and remained unchanged in 103(70.5%)patients after the *** the 35 patients who initially had trivial-to-moderate aortic regurgitation(AR),the degree of AR was ameliorated or disappeared in 25(71.4%)patients,aggravated from trivial to mild AR in 1(2.9%)patient,and remained unchanged in 9(25.7%)*** 111 patients without AR,1(0.9%)patient had mild AR and 24(21.6%)patients had trivial AR after *** depth and width of the prolapsed aortic valve decreased after transcatheter closure of VSD in all three *** the 70-month(range,54–77)follow-up period,no patients with AVP and AR needed an aortic valve ***:Transcatheter closure of VSD with AVP is *** morphology and function of the prolapsed aortic valve improved and remained stable for a long period after intervention.

关键词： ventricular septal defect aortic valve prolapse aortic regurgitation

Transcatheter ventricular septal defect Closure with Nit-Occlud LêVSD Device—Five Years’Experience and Literature Review

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Congenital Heart Disease 2023年第3期18卷 361-371页

作者： Ivana B.Cerović Vladislav A.Vukomanović Jovan Lj.Košutić Mila S.Stajević Sanja S.Ninić Saša S.Popović Ivan D.Dizdarević Staša D.Krasić Sergej M.Prijić Cardiology Department Mother and Child Health Institute of Serbia“Dr VukanČupić”Belgrade11070Serbia Faculty of Medicine University of BelgradeBelgrade11070Serbia

Introduction:Transcatheter closure is an alternative to ventricular septal defect(VSD)occlusion ***-Occlud LêVSD coil is a new device yet to be *** study aimed to evaluate immediate and midterm results after transcatheter closure with the Nit-Occlud LêVSD ***:The retrospective analysis included 30 patients with VSD referred for closure during the period from October 2015 to December ***:At the time of intervention,the patients’mean age and body weights were 7.5±5.6 years and 29.3±19.1 *** majority of the defects had perimembranous location(24/30),four defects had muscular and two outlet subaortic *** mean effective right-side diameter of the VSDs was 3.6±1.3 *** ventricular fibrillation,device embolization,and hemolysis developed in different patients and were successfully *** of the patients had a complete atrioventricular *** coil was successfully placed in 25/30(83.3%)*** majority of the devices were 10 mm×6 mm(11/25)and 12 mm×8 mm(8/25)in *** patients required the implantation of a second *** follow-up period was 2.1±1.4 *** VSD closure was achieved in 48%of cases immediately after the intervention,74%during 2.1±1.6 months after the procedure,and 81%over *** remaining patients had a trivial residual *** the follow-up,approximately one-third of patients developed trivial aortic and mitral valve regurgitation,and half of the patients acquired trace/mild tricuspid ***(z-score)left ventricular end-diastolic diameter(0.15±0.37 vs.0.92±0.82,p=0.005)and left atrium dimension(0.47±0.58 vs.1.89±1.11,p=0.005),as well as the left atrium to aortic root ratio(1.2±0.1 vs.1.4±0.2,p=0.005)showed a significant decrease over follow-up related to the period before ***:Intervention with Nit-OccludLêVSD coil showed appropriate results regarding VSD closure rate,complications,and chamber *** introduction of t

关键词： ventricular septal defect transcatheter device children

Surgical Repair of ventricular septal defect in Neonates: Indications and Outcomes

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Congenital Heart Disease 2024年第1期19卷 69-83页

作者： Jae Hong Lee Sungkyu Cho Jae Gun Kwak Hye Won Kwon Woong-Han Kim Mi Kyoung Song Sang-Yun Lee Gi Beom Kim Eun Jung Bae Department of Thoracic and Cardiovascular Surgery Research Institute for Convergence of Biomedical Science and TechnologyPusan National University Yangsan HospitalYangsanKorea Department of Thoracic and Cardiovascular Surgery Seoul National University Children’s HospitalSeoulKorea Department of Pediatrics Seoul National University Children’s HospitalSeoulKorea

Background:The optimal surgical timing and clinical outcomes of ventricular septal defect(VSD)closure in neo-nates remain *** aimed to evaluate the clinical outcomes of VSD closure in neonates(age≤30 days).Methods:We retrospectively reviewed 50 consecutive neonates who underwent VSD closure for isolated VSDs between August 2003 and June *** for the procedure included congestive heart failure/failure to thrive and pulmonary *** adverse events(MAEs)were deﬁned as the composite of all-cause mortality,reoperation,persistent atrioventricular block,and signiﬁcant(≥grade 2)valvular ***:The median age and body weight at operation were 26.0 days(interquartile range[IQR],18.8–28.3)and 3.7 kg(IQR,3.3–4.2),*** median follow-up duration was 110.4 months(IQR,56.8–165.0).Seven patients required preoperative respiratory support,andﬁve had signiﬁcant(≥grade 2)preoperative valvular *** early mortality occurred due to irreversible cardiogenic shock;no late mortality was *** reopera-tion was due to hemodynamically signiﬁcant residual VSD at 103.8 months *** overall survival,freedom from reoperation,and freedom from MAE at 15-years were 98.0%,96.3%,and 94.4%,***-operative mechanical ventilation was associated with a longer duration of postoperative mechanical ventilation(p<0.001)and a longer length of intensive care unit stay(p<0.001).Conclusions:VSD closure with favorable outcomes without morbidities is feasible even in ***,neonates requiring preoperative respiratory support may require careful postoperative management considering the long-term postoperative ***,surgical VSD closure might be indicated earlier in neonates with respiratory compromise.

关键词： ventricular septal defect neonate early surgery neonatal surgery

Effects of General Anesthesia on the Results of Cardiac Catheterization in Pediatric Patients with ventricular septal defect

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Congenital Heart Disease 2023年第2期18卷 235-243页

作者： Kiyotaka Go Taichi Kato Machiko Kito Yoshihito Morimoto Satoru Kawai Hidenori Yamamoto Yoshie Fukasawa Kazushi Yasuda Department of Pediatric Cardiology Aichi Children’s Health and Medical CenterObu474-8710Japan Department of Pediatrics Nagoya University Graduate School of MedicineNagoya466-8560Japan

Background:There is no gold standard sedation method for pediatric cardiac *** congenital heart diseases with intracardiac shunts,hemodynamic parameters are prone to change depending on the ventilation conditions and anesthetics,although few studies have examined these *** purpose of this study was to investigate the effects of two different sedation methods on the hemodynamic ***:This study retrospectively evaluated consecutive patients with ventricular septal defect(VSD)below 1 year of age who underwent cardiac catheterization at Aichi Children’s Health and Medical Center,who were divided into age-and VSD diameter-matched general anesthesia(GA)and monitored anesthesia care(MAC)under the natural airway groups(n=40 each),for comparison of hemodynamic ***:In the GA group,arterial blood pH and arterial partial pressure of oxygen were significantly higher(p<0.01),whereas arterial partial pressure of carbon dioxide was significantly lower than in the MAC group(p<0.01).Mean pulmonary artery pressure(p<0.05)and systemic blood pressure(p<0.01)were lower in the GA *** vascular resistance index(p<0.01)and systemic vascular resistance index(p<0.01)were also significantly lower in the GA group than the MAC *** were no significant differences in pulmonary blood flow index,systemic blood flow index,and pulmonary/systemic blood flow ratio between the two ***:Cardiac catheterization under GA in VSD patients results in different hemodynamic parameters compared to that under *** particular,when using pulmonary artery pressure and pulmonary vascular resistance measured under GA for judgment regarding the surgical indications or perioperative management,consideration should be given to the fact that these parameters might be lower compared to those measured under MAC.

关键词： ventricular septal defect cardiac catheterization general anesthesia monitored anesthesia care

Transcatheter Closure of Perimembranous ventricular septal defect Using the Amplatzer Duct Occluder II

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Congenital Heart Disease 2021年第2期16卷 151-157页

作者： Hongxiao Sun Gang Luo Zhanhui Du Zhixian Ji Silin Pan Qingdao Women and Children’s Hospital Qingdao UniversityQingdao266034China

Objective:To evaluate the efficacy of Amplatzer duct occluder II(ADO II)in the treatment of perimembranous ventricular septal defect(pmVSD)in ***:Between June 2017 and June 2020,13 patients with pmVSD had attempted transcatheter closure using ADO II,seven of patients were used antegrade approach and six of them were used retrograde ***:There were 8 males and 5 females,age from 1 to 7 years,weight from 10.5 to 31.0 kg,and VSD size from 2.0 to 4.0 *** was successful in all cases with the outer diameter of the occluders ranging from 4 to 6 *** aortic,tricuspid regurgitation or residual shunt was found in the immediate ultrasound *** arrhythmia was observed in the Holter monitoring 3 days after the *** echocardiography indicated complete shunt *** evidence of occluder prolapse,malignant arrhythmia,or intensed valve regurgitation was seen on a median follow-up of 18 months(range,6 to 36 months).Conclusions:Based on our experience,ADO II showed good efficacy in the early and middle stages of pediatric pmVSD closures.

关键词： ventricular septal defect transcatheter closure Amplatzer duct occluder children

Evaluation of Biventricular Volume and Systolic Function in Children with ventricular septal defect and Moderate to Severe Pulmonary Hypertension Using Real-Time Three-Dimensional Echocardiography

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Congenital Heart Disease 2022年第6期17卷 697-707页

作者： Huan Zhou Jin Kang Jun Gao Xiaoyuan Feng Li Zhou Xia Xiao Zhengliang Meng Chengwen Guo Children’s Heart Center Wuhan Children’s Hospital(Wuhan Maternal and Child Healthcare Hospital)Tongji Medical CollegeHuazhong University of Science&TechnologyWuhanChina Department of Ultrasound Wuhan Children’s Hospital(Wuhan Maternal and Child Healthcare Hospital)Tongji Medical CollegeHuazhong University of Science&TechnologyWuhanChina

Background: Real-time three-dimensional echocardiography (RT-3DE) could obtain ventricular volume andejection fraction rapidly and non-invasively without relying on ventricular morphology. This study aims to useRT-3DE to evaluate the changes in biventricular volume and systolic function in children with ventricular septaldefect (VSD) and moderate to severe pulmonary hypertension (PH) before surgery. Methods: In this study18 children with VSD and moderate to severe PH (VSD + PH Group) and 18 healthy children of the sameage (Control Group) were recruited. Biventricular volume and systolic function were evaluated by *** measurements included: left and right ventricular volume indexed to body surface area (BSA), stroke volume(SV) indexed to BSA, and ejection fraction (EF). Results: The results showed left and right ventricular volumeindexed to BSA and SV indexed to BSA were significantly increased in VSD + PH Group (VSD + PH Groupvs. Control Group), LVEDV/BSA (ml/m2): 48.67 ± 21.46 vs. 25.59 ± 6.96, RVEDV/BSA (ml/m2): 55.98 ±15.35 vs. 27.69 ± 4.37, LVSV/BSA (ml/m2): 24.08 ± 9.30 vs. 15.14 ± 4.29, RVSV/BSA (ml/m2): 26.02 ± 8.87 vs.14.11 ± 2.89, (P ventricular volume and decreased systolic functionwere observed with RT-3DE, but biventricular systolic function remained within acceptable limits. The childrenin this study recovered well after surgery without serious perioperative complications, suggesting that biventricularsystolic function may help facilitate the surgical decision-making process in children with VSD and moderate-toseverePH.

关键词： Real-time three-dimensional echocardiography ventricular septal defect pulmonary hypertension children

Restrictive perimembranous ventricular septal defect with left to right Shunt post urgent aortic balloon valvuloplasty and transcatheter aortic valve replacement

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Journal of Geriatric Cardiology 2018年第1期15卷 113-116页

作者： Emmanouil Chourdakis Ioanna Konlari Nicholas G Kounis Dimitrios Velissaris George Hahalis Karl Eugen Hauptmann Cardiology Department Hospital of the Brothers of Mercy Trier Germany Cardiology Department Queen Elizabeth University Hospital Birmingham UK Cardiology Department Patras University Hospital Rio Patras Greece

An 86-year-old male patient was admitted in our cardiology ward with signs of congestive biventricular heart failure. The patient presented with deteriorating dyspnea on mild exertion and at rest the last days, compatible with class NYHA Ⅲ-Ⅳ heart failure, bilateral peripheral oedema, increased NT-proBNP （9198 pg/mL）, mildly elevated Troponin （TnT 64 pg/mL）, interstitial pulmonary oedema and bilateral pleural effusions in chest X ray.

关键词： Aortic stenosis Aortic rupture Shunt Transcatheter aortic valve replacement Valvuloplasty ventricular septal defect

Minimally Invasive Perventricular Device Closure of ventricular septal defect: a Comparative Study in 80 Patients

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Chinese Medical Sciences Journal 2014年第2期29卷 98-102页

作者： Xin-chao Yang De-bin Liu Department of Cardiovascular Surgery the First Clinical Hospital of Lanzhou University

Objective To evaluate the efficacy of minimally invasive perventricular device closure of ventricular septal defect(VSD). Methods Between September 2011 and February 2013, we collected 40 patients who underwent perventricular closure via a small lower sternal incision(minimally invasive group), aged 15.5±3.5 years(12 months to 32 years) with a body weight of 24.2±7.5 kg(10.8-58.0 kg). The mean size of VSD was 5.6±0.5 mm(2-14 mm). Another 40 patients were included as the surgical group, receiving the conventional surgical repair of VSD. The device of the minimally invasive group was released under the guidance of transesophageal echocardiography. Success rate, cardiac indicators, and clinical outcomes of the 2 groups were compared. Results The patients in the surgical group and those in the minimally invasive group showed similar results in success rate(both 97.5%). The procedure time, intensive care unit stay, hospital stay, and postoperative recovery time in the minimally invasive group were significantly shorter than those in the surgical group(58±21 minutes versus 145±26 minutes, 2±1 days versus 8±3 days, 5±1 days versus 16±6 days, 3±1 days versus 90±20 days, all Pventricular device closure of VSD under transesophageal echocardiography guidance is similar to that of conventional surgical repair, but the short-term outcomes of the minimally invasive approach is much better. Long-term follow-up is necessary to confirm the effectiveness of this technique.

关键词： transesophageal echocardiography minimally invasive ventricular septal defect