检索结果-南通市图书馆

检索条件"主题词=Ventral lateral thalamus"

共 1 条记录，以下是1-10 订阅

全选清除本页清除全部题录导出标记到"检索档案"

详细简洁

排序：

A cerebellar inhibitory signal for the regulation of sleep-wakefulness cycle

A cerebellar inhibitory signal for the regulation of sleep-w...

引用

中国睡眠研究会第十一届全国学术年会

作者： Bo Hu Li-Bin Zhang Jie Zhang Army Medical University

The cerebellum is a critical component of the CSN, involved in motor control and motor learning. However, patients suffering from cerebellar disorders induce not only motor deficits, but also non-motor symptoms such as increased daytime sleepiness. Vice versa, patients suffering primary sleep disorders such as daytime sleepiness are often accompanied by a decreased cerebellar volume. These data support the notion that the cerebellum might be involved in regulating sleep and wakefulness. Nevertheless, the neural mechanisms underlying this involvement remain largely unclear. Here, we examined a genetically tractable population of neurons in the mouse deep cerebellar nuclei（DCN）, whose axon fibers specifically project to the ventral lateral thalamus（VL）. We show that these neurons are composed of GABAergic（～50%）, Glycinergic（～25%） and Glutamatergic（～25%） neurons in the DCN. Therefore, most of the VL-projected DCN neurons are inhibitory units. Intriguingly, the inhibitory VL-projected DCN neurons also recurrently innervate in the cerebellar cortex. Immnohistochemmical staining reveal that the nucleocortical fiber terminals formed filopodia-like protrusions in the vicinity of Purkinje cell（PC） layer in the cerebellar cortex, indicating these fibers preferentially target the PCs. Indeed, optogenetic inhibition of the VL-projected DCN neurons disinhibits the PCs in the cerebellar cortex, which thereafter cause widespread inhibition in the DCN. Vice versa, optogenetic stimulation of the VL-projected DCN neurons induces rapid inhibition of the PCs, which results in widespread excitation in the DCN. It turns out that the inhibitory VL-projected DCN neurons can bi-directionally modulate the activities of PCs in the cerebellar cortex. In contrast, optogenetic activation of VL/VM-projected glutamatergic DCN neurons fails to induce widespread excitation in the DCN. Moreover, optogenetic activation of the VL-projected DCN neurons can provide an internal amplification of the outputs from the cerebellar cortex, as evidenced by th

关键词： Deep cerebellar nuclei ventral lateral thalamus Purkinje cell Sleep Wakefulness Multiple units recording Optogenetics Chemogenetics

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

全选清除本页清除全部题录导出标记到“检索档案”

共1页 << < 1 > >>

回到顶部

执行限定条件

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：