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In vitro vasodilatory effect of aqueous leaf extract of Thymus serrulatus on thoracic aorta of Guinea pigs

Asian Pacific Journal of Tropical Biomedicine 2015年第1期5卷 15-18页

作者： Bekesho Geleta Mebrahtu Eyasu Selamu Kebamo Asfaw Debella Eyasu Makonnen Abiy Abebe Directorate of Traditional and Modern Medicine Research Ethiopian Public Health Institute St.Paul's Hospital Millennium Medical College Department of Pharmacology Wollega University Department of Pharmacology Addis Ababa University College of Health SciencesSchool of MedicineDepartment of Pharmacology

Objective:To investigate the vasodilatory effecl of Thymus serrulatus(***) aqueous leaf extract on KCl(high K^+.80 mmol/L) induced precontracted isolated thoracic aorta rings on guinea pigs and the role of aorta endothelium on this ***:Guinea pig thoracic aorta was removed and placed in an organ bath containing Krebs-Henseleit solution and aorta contractions were recorded ***:The results revealed that *** aqueous leaf extract(0.5-5 mg/mL)significantly(Pvasodilatory effect of the extract on intact endothelium was significantly(Pvasodilatory effect of extract in intact endothelium as compared to methylene blue(10μmol/L).atropine(10 μmol/L) and indomethacin(10 μmol/L).The effecl was more obvious on intact than that on denuded ***:The present findings demonstrate that *** aqueous leaf extract has vasodilator)' activity which might result in antihypertensive effect and its vasodilatory effect is *** might support the traditional claim of the plant in hypertensive.

关键词： Thymus serrulatus Guinea pig Aqueous extract Endothelium Organ bath vasodilatory effect

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Early vasopressin initiation for pediatric patients with vasodilatory shock after cardiac surgery

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中国循环杂志 2018年第S1期33卷 152-152页

作者： Zhongyuan Lu Xu Wang Juxian Yang Shengli Li Min Zeng Xia Li PICU Pediatric Cardiac CenterNational Center for Cardiovascular DiseasesFuwai HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijingChina

Objective Vasopressin has showed a beneficial use in pediatric patients with vasodilatory shock after cardiac surgery. However, the optimal timing of vasopressin initiation has not been *** aim was to evaluate the eff... 详细信息

关键词： pediatric patients vasodilatory shock cardiac surgery

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Protective effects of orally administered honokiol on cerebral ischemia reperfusion in rats and on stroke in SHRsp

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Journal of Chinese Pharmaceutical Sciences 2016年第12期25卷 882-891页

作者： Xiaoyan Liu Zhenyu Hu Shizhong Chen Jiancheng Wang Yinye Wang Department of Molecular and Cellular Pharmacology School of Pharmaceutical Sciences Peking University Health Science Center Beij ing 100191 China Department of Natural Medicines School of Pharmaceutical Sciences Peking University Health Science Center Beijing 100191 China Department of Pharmaceutics School of Pharmaceutical Science Peking University Health Science Center Beijing 1O0191 China

Honokiol is a protective agent for cerebral ischemia injury when administered intravenously. In the present study, we aimed to investigate the oral effect of honokiol microemulsion on cerebral isehemia-reperfusion （I-R） injury in rats and stroke in SHRsp. Both tMCAO and SHRsp models in rats were used to evaluate the efficacy of the microemulsion. Rat aortic segment contraction test, primary rat aortic endothelial cells and primary brain microvascular endothelial cells （BMECs） injured by OGD-R were used to explore its potential action mechanism. Oral honokiol microemulsion significantly reduced infarct volume, neurological score and brain water content in tMCAO model, and it evidently reduced neurological score and increased the survival rate of SHRsp. Moreover, honokiol significantly inhibited aortic contraction induced by KC1 and phenylephrine, and L-NAME suppressed these inhibitory effects. On the other side, honokiol increased NO and p-eNOS levels in rat endothelial cells. In addition, it also protects BMECs against OGD-R injury and increased eNOS expression in BMECs. In conclusion, oral honokiol administration has protective effects in tMCAO and in SHRsp rats, and its action mechanism is likely to be associated with its vasodilative effect produced by eNOS activation and with its protective effect on BMECs.

关键词： Honokiol Cerebral ischemia-reperfusion SHRsp vasodilatory eNOS

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