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Multiscale morphological analysis of bone microarchitecture around Mg-10Gd implants

Bioactive Materials 2023年第12期30卷 154-168页

作者： Sandra Sefa Jonathan Espiritu Hanna Cwieka Imke Greving Silja Flenner Olga Will Susanne Beuer D.C Florian Wieland Regine Willumeit-Romer Berit Zeller-Plumhoff Institute of Metallic Biomaterials Helmholtz Zentrum HereonGeesthachtGermany Syntellix AG HannoverGermany Institute of Materials Physics Helmholtz Zentrum HereonGeesthachtGermany Molecular Imaging North Competence Center Kiel UniversityKielGermany Fraunhofer Institut für Integrierte Systeme und Bauelementetechnologie(IISB) ErlangenGermany

The utilization of biodegradable magnesium(Mg)-based implants for restoration of bone function following trauma represents a transformative approach in orthopaedic *** such alloy,magnesium-10 weight percent gadolinium(Mg-10Gd),has been specifically developed to address the rapid degradation of Mg while enhancing its mechanical properties to promote bone *** studies have demonstrated that Mg-10Gd exhibits favorable osseointegration;however,it exhibits distinct ultrastructural adaptation in comparison to conventional implants like titanium(Ti).A crucial aspect that remains unexplored is the impact of Mg-10Gd degradation on the bone *** address this,we employed hierarchical three-dimensional imaging using synchrotron radiation in conjunction with image-based finite element *** using the methods outlined,the vascular porosity,lacunar porosity and the lacunar-canaliculi network(LCN)morphology of bone around Mg-10Gd in comparison to Ti in a rat model from 4 weeks to 20 weeks post-implantation was *** investigation revealed that within our observation period,the degradation of Mg-10Gd implants was associated with significantly lower(p<0.05)lacunar density in the surrounding bone,compared to ***,the LCN morphology and the fluid flow analysis did not significantly differ for both implant *** summary,a more pronounced lower lacunae distribution rather than their morphological changes was detected in the surrounding bone upon the degradation of Mg-10Gd *** implies potential disparities in bone remodelling rates when compared to Ti *** findings shed light on the intricate relationship between Mg-10Gd degradation and bone microarchitecture,contributing to a deeper understanding of the implications for successful osseointegration.

关键词： Biodegradable magnesium implants Lacunar-canalicular network(LCN) vascular porosity Synchrotron radiation micro computed tomography(SRμCT) Transmission x-ray microscopy(TXM)

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