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Role of activin receptor-like kinase 1 in Vascular development and cerebrovascular diseases

Neural Regeneration Research 2020年第10期15卷 1807-1813页

作者： Jun-Mou Hong Yi-Da Hu Xiao-Qing Chai Chao-Liang Tang Department of vascular Surgery Zhongshan HospitalXiamen UniversityXiamenFujian ProvinceChina Department of Anesthesiology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina Department of Anesthesiology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina

Activin receptor-like kinase 1(ALK1)is a transmembrane serine/threonine receptor kinase of the transforming growth factor beta(TGFβ)receptor superfamily.ALK1 is specifically expressed in vascular endothelial cells,and its dynamic changes are closely related to the proliferation of endothelial cells,the recruitment of pericytes to blood vessels,and functional differentiation during embryonic Vascular development.The pathophysiology of many cerebrovascular diseases is today understood as a disorder of endothelial cell function and an imbalance in the proportion of vascular cells.Indeed,mutations in ALK1 and its co-receptor endoglin are major genetic risk factors for vascular arteriovenous malformation.Many studies have shown that ALK1 is closely related to the development of cerebral aneurysms,arteriovenous malformations,and cerebral atherosclerosis.In this review,we describe the various roles of ALK1 in the regulation of angiogenesis and in the maintenance of cerebral vascular homeostasis,and we discuss its relationship to functional dysregulation in cerebrovascular diseases.This review should provide new perspectives for basic research on cerebrovascular diseases and offer more effective targets and strategies for clinical diagnosis,treatment,and prevention.

关键词： activin receptor-like kinase 1 aneurysm atherosclerotic plaque endoglin extracellular matrix protein intracranial arteriovenous malformation matrix metalloproteinase pericyte transforming growth factor beta 1 pathway Vascular development

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SERK Family Receptor-like Kinases Function as Co-receptors with PXY for Plant Vascular development

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Molecular Plant 2016年第10期9卷 1406-1414页

作者： Heqiao Zhang Xiaoya Lin Zhifu Han Jizong Wang Li-Jia Qu Jijie Chai Ministry of Education Key Laboratory of Protein Science Center for Structural Biology School of Life Sciences Tsinghua-Peking Joint Center for Life SciencesTsinghua University Beijing 100084 China State Key Laboratory of Protein and Plant Gene Research School of Life Sciences Peking-Tsinghua Joint Center for Life Sciences Peking UniversityBeijing 100871 China

In Arabidopsis, the CLAVATA3/EMBRYO SURROUNDING REGION-RELATED （CLE） peptides play important roles in regulating proliferation and differentiation of plant-specific stem cells. Although receptors of CLEs are reported to be leucine-rich repeat receptor kinases, the mechanisms underlying CLE-induced receptor activation remain largely unknown. Here we show that SOMATIC EMBRYOGENESIS RECEPTOR KINASEs （SERKs） serve as co-receptors in CLE41/TDIF-PXY signaling to regulate plant Vascular development. TDIF induces interaction of its receptor PXY with SERKs in vitro and in vivo. Furthermore, the serk1-1 serk2-1 bakl-5 mutant plants are less sensitive to TDIF, phenocopying the pxy mutant with a compromised promotion of procambial cell proliferation. Crystal structure of the PXY-TDIF-SERK2 complex reveals that the last amino acid of TDIF conserved among CLEs and other evolutionary-related peptides is important for the interaction between SERK2 and PXY. Taken together, our current study identifies SERKs as signaling components of the TDIF-PXY pathway and suggests a conserved activation mechanism of CLE receptors.

关键词： receptor-like kinase SERK PXY-TDIF Vascular development co-receptor

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CLE Peptides in Vascular development

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Journal of Integrative Plant Biology 2013年第4期55卷 389-394页

作者： Yi Qiang Jinbin Wu Huibin Han Guodong Wang Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry Ministry of Education National Engineering Laboratory forResource Developing of Endangered Chinese Crude Drugs in Northwest of China College of Life Sciences Shaanxi Normal University

The plant vascular system consists of two conductive tissues, phloem and xylem. The vascular meristem, namely the （pro-）cambium, is a stem- cell tissue that gives rise to both xylem and phloem. Recent studies have revealed that CLAVATA3/Embryo Surrounding Region-related （CLE） pep- tides function in establishing the vascular system through interaction with phytohormones. In particular, TDIF/CLE41/CLE44, phloem-derived CLE peptides, promote the proliferation of vascular cambium cells and prevent them from differentiating into xylem by regulating WOX4 expres- sion through the TDR/PXY receptor. In this review article, we outline recent advances on how CLE peptides function in Vascular developmentin concert with phytohormones through mediating cell-cell communication. The perspective of CLE peptide signaling in Vascular development is also discussed.

关键词： CLE peptide Vascular development （pro-）cambium xylem phytohormone Arabidopsis.

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The Plant vascular System: Evolution, development and Functions

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Journal of Integrative Plant Biology 2013年第4期55卷 294-388页

作者： William J. Lucas Andrew Groover Raffael Lichtenberger Kaori Furuta Shri-Ram Yadav Yk Helariutta Xin-Qiang He Hiroo Fukuda Julie Kang Siobhan M. Brady John W. Patrick John Sperry Akiko Yoshida Ana-Flor López-Millan Michael A. Grusak Pradeep Kachroo Department of Plant Biology College of Biological Sciences University of California US Forest Service Pacific SW Res Stn Institute for Forest Genetics Institute of Biotechnology/Department of Biology and Environmental Sciences University of Helsinki State Key Laboratory of Protein and Plant Gene Research College of Life Sciences Peking University Department of Biological Sciences Graduate School of Science The University of Tokyo Biology Department University of Northern Iowa School of Environmental and Life Sciences The University of Newcastle Biology Department University of Utah Plant Nutrition Department Aula Dei Experimental Station (CSIC) USDA-ARS Children's Nutrition Research Center Department of Pediatrics Baylor College of Medicine Department of Plant Pathology College of Agriculture University of Kentucky

The emergence of the tracheophyte-based vascular system of land plants had major impacts on the evolution of terrestrial biology, in general, through its role in facilitating the development of plants with increased stature, photosynthetic output, and ability to colonize a greatly expanded range of environmental habitats. Recently, considerable progress has been made in terms of our understanding of the developmental and physiological programs involved in the formation and function of the plant vascular system. In this review, we first examine the evolutionary events that gave rise to the tracheophytes, followed by analysis of the genetic and hormonal networks that cooperate to orchestrate Vascular development in the gymnosperms and angiosperms. The two essentialfunctions performed by the vascular system, namely the delivery of resources （water, essential mineral nutrients, sugars and amino acids） to the various plant organs and provision of mechanical support are next discussed. Here, we focus on critical questions relating to structural and physiological properties controlling the delivery of material through the xylem and phloem. Recent discoveries into the role of the vascular system as an effective long-distance communication system are next assessed in terms of the coordination of developmental, physiological and defense-related processes, at the whole-plant level. A concerted effort has been made to integrate all these new findings into a comprehensive picture of the state-of-the-art in the area of plant vascular biology. Finally, areas important for future research are highlighted in terms of their likely contribution both to basic knowledge and applications to primary industry.

关键词： Evolution Vascular development phloem xylem nutrient delivery long-distance communication systemic signaling.

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Functional Study of LRR-RLK Receptor Kinases and CLE Peptide Hormone in Plant Vascular development

Functional Study of LRR-RLK Receptor Kinases and CLE Peptide...

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植物分子生物学与现代农业——2010全国植物生物学研讨...

作者： Bo Zheng~* College of Horticultural and Forestry Sciences,HuaZhong Agricultural University,Wuhan 430070

Leucine-rich repeat receptors like kinases(LRR-RLKs) represent the largest group of protein receptor kinases in the Arabidopsis thaliana genome,with more than 200 members,and play roles in diverse biological processes... 详细信息

关键词： LRR-RLK CLE peptide Vascular development

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Effects of long non-coding RNA myocardial infarction-associated transcript on retinal neovascularization in a newborn mouse model of oxygen-induced retinopathy

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Neural Regeneration Research 2021年第9期16卷 1877-1881页

作者： Yu Di Yue Wang Xue Wang Qing-Zhu Nie Department of Ophthalmology Shengjing Hospital of China Medical UniversityShenyangLiaoning ProvinceChina

Whether long non-coding RNA myocardial infarction-associated transcript is involved in oxygen-induced retinopathy remains poorly understood. To validate this hypothesis, we established a newborn mouse model of oxygen-induced retinopathy by feeding in an oxygen concentration of 75 ± 2% from postnatal day 8 to postnatal day 12, followed by in normal air. On postnatal day 11, the mice were injected with the myocardial infarction-associated transcript siRNA plasmid via the vitreous cavity to knockdown long non-coding RNA myocardial infarction-associated transcript. Myocardial infarction-associated transcript siRNA transcription significantly inhibited myocardial infarctionassociated transcript mRNA expression, reduced the phosphatidylinosital-3-kinase, phosphorylated Akt and vascular endothelial growth factor immunopositivities, protein and mRNA expression, and alleviated the pathological damage to the retina of oxygen-induced retinopathy mouse models. These findings suggest that myocardial infarction-associated transcript is likely involved in the retinal neovascularization in retinopathy of prematurity and that inhibition of myocardial infarction-associated transcript can downregulate phosphatidylinosital-3-kinase, phosphorylated Akt and vascular endothelial growth factor expression levels and inhibit neovascularization. This study was approved by the Animal Ethics Committee of Shengjing Hospital of China Medical University, China(approval No. 2016 PS074 K) on February 25, 2016.

关键词： long non-coding RNA myocardial infarction-associated transcript neovascularization neurovascular prematurity retinopathy Vascular development vascular endothelial growth factor

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AB002. Guidance of vascular patterning in ocular development and disease

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Annals of Eye Science 2018年第1期 408-408页

作者： Anne Eichmann Departments of Cardiology and Cellular and Molecular Physiology Yale University School of MedicineNew HavenCTUSA Inserm Paris Cardiovascular Research Center ParisFrance

Ocular vessel networks develop in a highly stereotyped fashion.Abnormal ocular angiogenesis is associated with major diseases including age-related macular degeneration and diabetic retinopathy.Better understanding of mechanisms driving angiogenesis is expected to uncover novel targets to prevent vision loss.Capillary growth is driven by endothelial tip cells,which are selected by dynamic interplay between VEGF,Notch and BMP signaling,with VEGF acting as a positive regulator,and Notch and the BMP receptor Alk1 acting as negative regulators of tip cell formation.The concerted interplay between these molecules ensures that appropriate tip cell numbers leading new vessel branches are formed.In addition,guidance receptors including Neuropilins and Roundabout receptors contribute to vascular patterning by regulating VEGF and BMP signaling.Possibilities to target these pathways during pathological ocular neovascularization will be discussed.

关键词： Vascular development VEGF notch and BMP signaling

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Role of Axonal Guidance Factor Netrin-1 in Human Placental vascular Growth

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2011年第2期31卷 246-250页

作者：王乾华朱剑文邹丽杨昀 Department of Gynecology and Obstetrics Union Hospital Huazhong University of Science and Technology

This study investigated the role of netrin-1 in placental Vascular development. In vitro rat aortic ring assay and in vivo Matrigel plug assay were conducted to exmaine the effect of netrin-1 on angiogenesis. Human placental microvascular endothelial cells （HPMECs） were isolated and cultured and their viability, migration and tubular formation were studied, in order to examine the effects of netrin-1. The results showed that netrin-1 potently stimulated neovascularization in a mouse Matrigel plug in vivo and the sprouting of endothelial cells in rat aortic rings in vitro. In addition, netrin-1 enhanced the viability, migration and tube formation of HPMECs. Our study suggested that netrin-1 could significantly promote the formation of blood vessels of human placenta and may be a potential target for developing new therapeutic strategies for placental vasculature-related diseases.

关键词： netrin-1 placenta pregnancy Vascular development

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