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Mechanism underlying the protective effect of Kaixin Jieyu Fang on vascular depression following cerebral white matter damage

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Neural Regeneration Research 2014年第1期9卷 61-68页

作者： Ying Zhang Shijing Huang Yanyun Wang Junhua Pan Jun Zheng Xianhui Zhang Yuxia Chen Duojiao Li Guang’anmen Hospital China Academy of Chinese Medical Sciences

The Chinese compound Kaixin fieyu Fang can be used to treat vascular depression; however, the underlying mechanism remains unclear. This study established a rat model of chronic cerebral ischemia-caused white matter damage by ligation of the bilateral common carotid arteries. Rats received daily intragastric administration of a suspension of Kaixin ]ieyu Fang powder. After 3, 7 and 21 days of treatment, the degree of white matter damage in the cerebral ischemia rat model was alleviated, Bcl-2 protein and mRNA expression in brain tissue increased, and Bax protein and mRNA expression decreased. These results indicate that Kaixin Jieyu Fang can alleviate cere- bral white matter damage, and the underlying mechanism is associated with regulation of Bcl-2/ Bax protein and mRNA expression, which is one of possible mechanism behind the protective effect of Kaixin Jieyu Fang against vascular depression.

关键词： nerve regeneration vascular depression ligation of the bilateral common carotid arteries chronic cerebral ischemia white matter damage Kaixin ]ieyu Fang powder Bcl-2 Bax NSFC grant neural regeneration

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vascular depression for radiology: A review of the construct,methodology,and diagnosis

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World Journal of Radiology 2020年第5期12卷 48-67页

作者： Sara N Rushia Al Amira Safa Shehab Jeffrey N Motter Dakota A Egglefield Sophie Schiff Joel R Sneed Ernst Garcon Department of Psychology The Graduate CenterCity University of New YorkNew YorkNY 10016United States Department of Psychology Queens CollegeCity University of New YorkQueensNY 11367United States Division of Geriatric Psychiatry New York State Psychiatric InstituteNew YorkNY 10032United States Department of Psychiatry Columbia University Medical CenterNew YorkNY 10032United States Department of Radiology Columbia University Medical CenterNew YorkNY 10032United States

vascular depression(VD)as defined by magnetic resonance imaging(MRI)has been proposed as a unique subtype of late-life *** VD hypothesis posits that cerebrovascular disease,as characterized by the presence of MRIdefined white matter hyperintensities,contributes to and increases the risk for depression in older *** is also accompanied by cognitive impairment and poor antidepressant treatment *** VD diagnosis relies on MRI findings and yet this clinical entity is largely unfamiliar to neuroradiologists and is rarely,if ever,discussed in radiology *** primary purpose of this review is to introduce the MRI-defined VD construct to the neuroradiology *** reports are highlighted in order to illustrate the profile of VD in terms of radiological,clinical,and neuropsychological findings.A secondary purpose is to elucidate and elaborate on the measurement of cerebrovascular disease through visual rating scales and semi-and fully-automated volumetric *** methods are crucial for determining whether lesion burden or lesion severity is the dominant pathological contributor to ***,these rating methods have implications for the growing field of computer assisted *** VD has been found to have a profile that is distinct from other types of late-life depression,neuroradiologists,in conjunction with psychiatrists and psychologists,should consider VD in diagnosis and treatment planning.

关键词： vascular depression depression Magnetic resonance imaging Cerebrovascular disorders White matter hyperintensities Neuroradiology Case reports

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Effects of Kaixin Jieyu Decoction (开心解郁汤) on Behavior and Glial Fibrillary Acidic Protein Expression in Cerebral Hippocampus of A Rat vascular depression Model

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Chinese Journal of Integrative Medicine 2015年第3期21卷 223-228页

作者：张先慧黄世敬王彦云张颖潘菊华郑军李多娇雷小明 Traditional Chinese Medicine Research and Development Center Guang'anmen HospitalChina Academy of Chinese Medical Sciences

Objective：To explore the effects and anti-depression mechanisms of Kaixin Jieyu Decoction（开心解郁汤,KJD）.Methods：The rat vascular depression（VD） model was established by ligation of bilateral common carotid arteries（LBCCA） combined with chronic unpredictable mild stress（CUMS）.Forty Wistar rats were randomly divided into sham,VD model,VD ＋ high-dose KJD[15.4 g/（kg·d） of crude drug],VD ＋ medium-dose KJD[7.7 g/（kg·d） of crude drug],and VD ＋ fluoxetine[2.4 mg/（kg·d）]groups（r〉=8 in each group）,and the treatments lasted for 21 *** of behavior and hippocampus pathology were *** level of glial fibrillary acidic protein（GFAP）protein and mRNA in hippocampus was detected respectively by immunohistochemistry and real-time polymerase chain ***：Compared with the sham group,rats in model group showed a variety of behavioral obstacles,including a significant reduction in sucrose consumption percentage,horizontal and vertical activity scores in open-field tests（P〈0.05 or P〈0.01）,pathological damage like neuronal degeneration,necrosis,and a significant decrease of GFAP protein and mRNA in hippocampus（P〈0.01）;compared with the model group,rats in the high-dose KJD group,medium-dose KJD group and fluoxetine group obtained notable higher behavioral scores,and pathological injury lessened in hippocampus with a increased expression of GFAP protein and mRNA（P〈0.05 or P〈0.01）;compared with the medium-dose KJD group and fluoxetine group,GFAP mRNA in highdose KJD group expressed higer（P〈0.05）.Conclusion：LBCCA combined with CUMS may cause depression-like behavioral changes resulting in the VD model of rats whose depression state can be ameliorated by KJD,and the mechanism of cerebral protection is related possibly with promoting expression of GFAP in hippocampus.

关键词： vascular depression Kaixin Jieyu Decoction behavior glial fibrillary acidic protein Chinese meicine

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