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Prosthetic venous valves for chronic venous insufficiency:Advancements and future design directions

Medicine in Novel Technology and Devices 2024年第1期21卷 10-22页

作者： Qiushuo Zong Jing Liu Yunfei Chen Yuanyuan Kong Yiping Dang Zhihong Wang Department of Vascular Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Tianjin Key Laboratory of Biomaterial Research Institute of Biomedical EngineeringChinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin300192China Institute of Transplant Medicine Nankai University School of MedicineTianjin300071China

With the serious aging population and lifestyle changes,chronic venous insufficiency accounts for approximately 25.95%of the population,which may lead to lower limb edema and leg heaviness,as well as severe infections of skin ulcers that can result in sepsis and necessitate *** treatment and other supportive measures can only slow the disease's progression but are unable to drastically reverse it;surgical interventions are rarely used due to the high risk of catastrophic postoperative *** one of the most promising minimally invasive therapies,percutaneous prosthetic valve replacement has emerged in light of this situation,providing novel alternatives for patients with deep venous valve *** reviewed the historical prosthetic venous valve designs,including their structure and materials,animal evaluation models,and assessment *** the basis of the findings from in vitro tests,animal studies,and clinical trials,we summarized the major challenges and potential solutions for the development of advanced prosthetic venous valves.

关键词： Prosthetic venous valves Interventional venous valves Deep venous valve insufficiency Deep venous valve reflux valve leaflets valve design

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