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Valproic acid and nonalcoholic fatty liver disease: A possible association?

World Journal of Hepatology 2015年第9期7卷 1251-1257页

作者： Edoardo Farinelli David Giampaoli Anja Cenciarini Ephraim Cercado Alberto Verrotti Department of Pediatrics University of Perugia General Surgery Department Lung Center of the Philippines Quezon Avenue Diliman Quezon City 1101Metro Manila Philippines

Valproic acid(VPA) is one of the most prescribed drugs in children with newly diagnosed epilepsy. Weight gain and obesity have been observed as side effects of VPA. These are often linked with other metabolic disturbances such as development of insulin resistance, dyslipidemia, metabolic syndrome(Met S) and nonalcoholic fatty liver disease or nonalcoholic fatty liver disease(NAFLD). NAFLD refers to a group of liver disorders with marked hepatic steatosis. It is associated with an increased incidence of cardiovascular diseases and overall reduced life expectancy. NAFLD occurs in 20%-25% of the general population and it is known to be the most common cause of chronic liver disease. NAFLD therefore represents a major public health issue worldwide. This study reviews and summarizes relevant literature that supports the existence of an association between VPA therapy and the development of NAFLD in children. Long-term VPA-therapy appears to be associated with an increased risk of developing NAFLD. Further studies are needed to clarify the pathogenic mechanisms that lie behind this association and to standardize the options for the use of this drug in overweight patients and in those with risks for developing Met S and NAFLD.

关键词： Nonalcoholic fatty liver disease valproicacid Obesity Insulin resistance

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