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The effectiveness of the TAX 327 nomogram in predicting overall survival in Chinese patients with metastatic castration-resistant prostate cancer

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Asian Journal of Andrology 2013年第5期15卷 679-684页

作者： Xiao-Jie Bian Yao Zhu Yi-Jun Shen Jin-You Wang Chun-Guang Ma Hai-Liang Zhan Bo Dai Shi-Lin Zhang Xu-Dong Yao Ding-Wei Ye Department of Urology Fudan University Shanghai Cancer Center Shanghai 200032 China Department of Oncology Shanghai Medical College Fudan University Shanghai 200032 China

Based on the results of TAX 327, a nomogram was developed to predict the overall survival of metastatic castration-resistant prostate cancer （mCRPC） after first-line chemotherapy. The nomogram, however, has not been validated in an independent dataset, especially in a series out of clinical trials. Thus, the objective of the current study was to validate the TAX 327 nomogram in a community setting in China. A total of 146 patients with mCRPC who received first-line chemotherapy （docetaxel or mitoxantrone） were identified. Because clinical trials are limited in China's Mainland, those patients did not receive investigational treatment after the failure of first-line chemotherapy. The predicted overall survival rate was calculated from the TAX 327 nomogram. The validity of the model was assessed with discrimination, calibration and decision curve analysis. The median survival of the cohort was 21 months （docetaxel） and 19 months （mitoxantrone） at last follow-up. The predictive c-index of the TAX 327 nomogram was 0.66 （95% CI： 0.54-0.70）. The calibration plot demonstrated that the 2-year survival rate was underestimated by the nomogram. Decision curve analysis showed a net benefit of the nomogram at a threshold probability greater than 30%. In conclusion, the present validation study did not confirm the predictive value of the TAX 327 nomogram in a contemporary community series of men in China, and further studies with a large sample size to develop or validate nomograms for predicting survival and selecting therapies in advanced prostate cancer are necessary.

关键词： castration-resistant chemotherapy nomogram prostate cancer validation studies

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validation of the Trail Making Test B for the Cognitive Assessment of Patients with Cancer in Palliative Care

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Open Journal of Statistics 2014年第6期4卷 435-445页

作者： Juliano dos Santos Cibele Andrucioli de Mattos Pimenta Geana Paula Kurita Patricia Emilia Braga Per Sjogren National Cancer Institute-HC Ⅲ Rio de JaneiroBrazil Department of Medical Surgical Nursing School of NursingUniversity of Sao PauloSao PauloBrazil Rigshospitalet Section of Palliative MedicineMultidisciplinary Pain CentreCopenhagenDenmark

Introduction: Cognitive impairment is common in patients with cancer;however, studies examining the adaptation and validation of instruments for use in patients with cancer are scarce. Purpose: The purpose of this study was to validate the Trail Making Test B (TMT-B) for use in patients with cancer. Methods: Ninety-four outpatients receiving palliative treatment and 39 healthy companions were assessed. Patients were tested with the TMT-B and answered questions regarding the presence and intensity of pain, fatigue, quality of sleep, anxiety, and depression, at two time points with a 7-day inter-assessment interval. Results: The instrument discriminated between patients, who were slower, and healthy companions with respect to the time required to complete the test, but not in terms of the number of errors. The test was stable for the healthy companions across the two assessments in terms of time to complete the TMT-B and the number of errors;for patients, the instrument was stable only for the number of errors. Performance on the TMT-B did not correlate with pain, fatigue, depression, anxiety, or sensation of rest. Conclusions: TMT-B cannot be considered fully validated. Further studies incorporating and comparing other instruments evaluating executive function and mental flexibility are needed.

关键词： Cognition Executive Function Hospice Care Neoplasms Neuropsychological Tests validation studies

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Multidimensional Pain Inventory(MPI):Adaptation to Orthodontic Patients and Its Psychometric Properties

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Pain studies and Treatment 2019年第1期7卷 1-20页

作者： Lucas Arrais Campos Jose Aparecido da Silva Ary Santos-Pinto Joao Maroco Juliana Alvares Duarte Bonini Campos Department of Pediatric Dentistry and Orthodontics School of DentistrySao Paulo State University(UNESP)AraraquaraBrazil Department of Psychology Faculty of PhilosophySciences and LettersUniversity of Sao Paulo(USP)Ribeirao PretoBrazil Department of Psychology Institute of Human SciencesFederal University of Juiz de Fora(UFJF)Juiz de ForaBrazil Department of Psychological Sciences William James Center for ResearchUniversity Institute of PsychologicalSocialand Life Sciences(ISPA)LisbonPortugal Food Science and Nutrition Department School of Pharmaceutical SciencesSao Paulo State University(UNESP)AraraquaraBrazil

Background: Pain perception may result from orthodontic treatment and should be considered in clinical management. Its assessment should not be limited to the intensity of perceived pain but should also consider the psychosocial and behavioral aspects involved. Objective: The aims of this study were to adapt and validate the Multidimensional Pain Inventory (MPI) for orthodontic patients, and present a proposal to calculate an overall score of the pain-related aspects and compare these scores with the usual methodology used. Methods: Face validity of the MPI was estimated and orthodontic version (MPI-Orthodontic) was developed. Factorial validity was evaluated by confirmatory analysis. Convergent and discriminant validity and reliability were estimated. The fit of Second-Order Hierarchical Models was estimated. Concurrent validity of MPI-Orthodontic was evaluated against the Visual Analogue Scale. Invariance of the factorial models was evaluated for independent samples and according to sex and age. Overall score was calculated using the matrix of regression weights and compared to simple arithmetic mean. Results: 507 individuals (63.3% women;age: 26.32 (SD = 11.70) years) participated. For the fit of Part I (psychosocial aspects) of the MPI-Orthodontic, it added correlation between two items and excluded one item;for Part II (behavioral aspects) two items were excluded. The models presented adequate fit to the sample. Reliability was adequate. MPI-Orthodontic presented invariance for independent samples and adequate concurrent and divergent validity. Score obtained with the simple arithmetic mean was overestimated for Part I and underestimated for Part II. Conclusion: MPI-Orthodontic was valid, reliable and invariant for the evaluation of the orthodontic pain. It is recommended to calculate overall weighted scores for pain assessment.

关键词： Pain Measurement Orthodontics Psychometrics validation studies Multidimensional Pain Inventory

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Disordered eating behaviour and eating disorder among adolescents with type 1 diabetes:An integrative review

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World Journal of Meta-Analysis 2022年第5期10卷 244-254页

作者： Maria Conceição Santos Oliveira Cunha Francisco Clécio Silva Dutra Laura Martins Mendes Cavaleiro Brito Rejane Ferreira Costa Maria Wendiane Gueiros Gaspar Danilo Ferreira Sousa Márcio Flávio Moura deAraújo Maria Veraci Oliveira Queiroz Department of Nursing West Princess CollegeCrateús 63700-190CearáBrazil Department of Nursing Ceara State UniversityFortaleza 60714-903CearáBrazil Department of Health Family Oswaldo Cruz FoundationEusébio 61773-272CearáBrazil Department of Health Science University for the International Integration of Afro-Brazilian LusophonyRedenção 62790-000CearáBrazil Department of Nursing University for the International Integration of Afro-Brazilian LusophonyRedenção 62790-000Brazil

BACKGROUND Type 1 diabetes(DT1)in adolescents brings behavioural changes,altered nutritional habits,and eating *** To identify and analyze the validated instruments that examine the disordered eating behaviour and eating disorders among adolescents with *** An integrative review was accomplished based on the following databases:PubMed,LILACS,CINAHL,Scopus,Web of Science,and Reference Citation Analysis(RCA),including publications in Portuguese,English,or Spanish,without time limit and time *** The main instruments to evaluate disordered eating behaviour were The Diabetes Eating Problem Survey-Revised,The Diabetes Eating Problem Survey,and the eating attitudes test-26,and for eating disorders the main instruments used were The Bulimic Investigation Test of Edinburgh,The Binge Eating Scale,The Child Eating Disorder Examination,The five questions of the(Sick,Control,One,Fat and Food),and The Mind Youth *** instruments showed an effect in evaluating risks regarding nutritional habits or feeding grievances,with outcomes related to weight control,inadequate use of insulin,and glycaemia *** did not identify publication *** Around the world,the most used scale to study the risk of disordered eating behaviour or eating disorder is The Diabetes Eating Problem *** researchers use this scale to identify high scores in adolescents with DT1 and a relationship with poorer glycemic control and psychological problems related to body image.

关键词： Adolescent Type 1 diabetes mellitus validation studies Nutritional behaviour Eating disorder Review

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