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C-reactive protein is differentially modulated by co-existing infections,vitamin deficiencies and maternal factors in pregnant and lactating indigenous Panamanian women

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Infectious Diseases of Poverty 2017年第1期6卷 819-832页

作者： Doris Gonzalez-Fernandez Emerita del Carmen Pons Delfina Rueda Odalis Teresa Sinisterra Enrique Murillo Marilyn E.Scott Kristine G.Koski School of Dietetics and Human Nutrition Macdonald Campus of McGill University21111 Lakeshore RoadSte-Anne-de-BellevueQC H9X 3V9Canada Department of Nutritional Health Ministry of HealthAnconPanama CityPanama “Comarca Ngabe-Bugle”Health Region Ministry of HealthSan FelixChiriqui ProvincePanama “Panama Norte”Health Region Ministry of HealthLas Cumbres SquareTransithmian HighwayPanama CityPanama Department of Biochemistry University of PanamaSimon Bolivar Avenue(Transithmian Highway)Panama CityPanama Department of Biochemistry University of PanamaManuel Espinoza Batista and Jose De Fabrega AvenuesPanama CityPanama Institute of Parasitology and Centre for Host-Parasite Interactions Macdonald Campus of McGill University21111 Lakeshore RoadSte-Anne-de-BellevueQC H9X 3 V9Canada School of Dietetics and Human Nutrition and Centre for Host-Parasite Interactions Macdonald CampusMcGill University21111 Lakeshore RoadSte-Anne-de-BellevueQC H9X 3 V9Canada

Background:The usefulness of C-reactive protein(CRP)as a non-specific marker of inflammation during pregnancy and lactation is unclear in impoverished populations where co-existing infections and vitamin deficiencies are common.Methods:This cross-sectional study in Panama recruited 120 pregnant and 99 lactating Ngäbe-Buglewomen from 14 communities in rural Panama.Obstetric history,indoor wood smoke exposure,fieldwork,BMI,vitamins A,B_(12),D,and folic acid,and inflammation markers(CRP,neutrophil/lymphocyte ratio(NLR),plateletcrit and cytokines)were measured.Multiple regressions explored both associations of CRP with other inflammatory markers and associations of CRP and elevated CRP based on trimester-specific cut-offs with maternal factors,infections and vitamin deficiencies.Results:CRP was higher in pregnancy(51.4±4.7 nmol/L)than lactation(27.8±3.5 nmol/L)and was elevated above trimester specific cut-offs in 21%of pregnant and 30%of lactating women.Vitamin deficiencies were common(vitamin A 29.6%;vitamin D 68.5%;vitamin B1268%;folic acid 25.5%)and over 50%of women had two or more concurrent deficiencies as well as multiple infections.Multiple regression models highlighted differences in variables associated with CRP between pregnancy and lactation.In pregnancy,CRP was positively associated with greater indoor wood smoke exposure,caries and hookworm and negatively associated with Ascaris and vaginal Lactobacillus and Bacteroides/Gardnerella scores.Consistent with this,greater wood smoke exposure,caries as well as higher diplococcal infection score increased the odds of trimester-elevated CRP concentrations whereas longer gestational age lowered the likelihood of a trimester-elevated CRP.During lactation,folic acid deficiency was associated with higher CRP whereas parity,number of eosinophils and Mobiluncus score were associated with lower CRP.Also,a higher BMI and Trichomonas vaginalis score increased the likelihood of an elevated CRP whereas higher parity and number of eosinophils were associated with lower like

关键词： CRP Intestinal parasites Caries vaginal infections Folic acid deficiency Wood smoke Neutrophil/lymphocyte ratio Plateletcrit Pregnancy Lactation

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Electrospinning Polylactic Acid Polymer Membranes as Biological Sieve for Yeast and Bacteria

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Materials Sciences and Applications 2022年第6期13卷 389-400页

作者： Ernesto Suaste-Gómez Grissel Rodríguez-Roldán Ilian Pérez-Solis Ana Laura Torres-Huerta Carlos Cruz-Cruz José Tapia-Ramírez Department of Electrical Engineering Section of Bioelectronics Center for Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV) Mexico City Mexico National Laboratory of Experimental Services (LaNSE) CINVESTAV Mexico City Mexico Department of Genetics and Molecular Biology CINVESTAV Mexico City Mexico

vaginal infections are suffered by millions of women of reproductive age. Recent research has shown that timely diagnosis of these infections avoids complications in the patient’s health. Since the symptoms of infections caused by yeast and bacteria are similar, the patient is not always treated properly. Membranes with three different thicknesses (66 μm, 83 μm, 128 μm) were produced by electrospinning of polylactic polymer (PLA) and were used as a biological sieve to detect microorganisms present in vaginal infections, bacteria or yeasts. Electrospinning technique is a technique that allows the generation of membranes from nanofibers of material polymeric and therefore, obtaining porous structures. The size of the fibers was observed as well as the morphology and the size of the pores, using the scanning electron microscopy (SEM). The effectiveness of these membranes was proven by the cultivation of the bacteria that passed through the polymeric membrane and the yeasts retained by it. The membranes allowed the retention of yeasts of Candida albicans type with dimensions of 7 μm, which allowed the separation of Brevibacterium ravens purgense bacteria with dimensions of 1.4 μm, thus demonstrating their effectiveness as biological sieve.

关键词： Biological Sieve Electrospinning Polylactic Acid vaginal infections

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Use of the Scar Acceleration Method - Mac<sup>®</sup>in the Treatment of Vulvovaginal Candidiasis: A Proposal for Treatment in Public Health in Sus, Brazil

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Open Journal of Applied Sciences 2020年第11期10卷 758-765页

作者： Marcus Vinícius de Mello Pinto Miriam Viviane Baron Mikaela da Silva Corrêa Juliana Berton Carla Ohana Castanho de Mattos Mariane Pieczaki Aline Ronis Esteban Fortuny Mirela Rodrigues Padilha Instituto Celulare Petrópolis Brazil Diagnostra Clinic Santiago Chile The Postgraduate Program in Medicine and Health Sciences at the Pontifical Catholic University of Rio Grande do Sul Porto Alegre Brazil The Physiotherapy Course at the Higher Education Center of Campos Gerais—CESCAGE Ponta Grossa Brazil The Pharmacy Course at the Higher Education Center of Campos Gerais—CESCAGE Ponta Grossa Brazil

Vulvovaginal candidiasis is an infection of the genital mucosa, which involves the vulva and vagina caused by yeast. It is considered a recurrent pathology and a public health problem that causes discomfort by the triggers and that, when left untreated, can lead to health problems. The present study is a report of two cases treated with the MAC® - Scar Acceleration Method - (MAC®) methodology at the Physiotherapy School Clinic of Teaching Center of Campos Gerais (CESCAGE) as a pilot for the proposal to implement the protocol at the Municipal Center for Women’s Health—CMM in the municipality of Ponta Grossa—PR, Brazil. The patients were referred by Basic Health Units in the city with complaints of pruritus, vaginal discharge and local burning with the diagnosis of candidiasis evidenced by culture and antibiogram. Patients were treated with photodynamic therapy using the MAC® method for 14 consecutive days with 660 nm red laser phototherapy, 100 mW of power, 9 joules of energy, photosensitizing the drug Turmeric Long in one of the participants and propolis in the other, using 1% methylene blue dye. Both patients and researchers did not have access to which drug was being used for ea

关键词： Candidiasis vaginal infections Women’s Health Methylene Blue Photodynamic Therapy

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