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Antifertility Activity of Hydroalcoholic Extract of Ocimum Basilicum Linn. Leaves on Female Wistar Rats

Journal of Reproduction and Contraception 2013年第1期24卷 45-54页

作者： Alia Bilal Nasreen Jahan Ajij Ahmed Saima Naaz Bilal Shahida Habib Department of Ilmul Advia (Pharmacology) National Institute of Unani Medicine Department of Obstetrics and Gyneacology M.I.J. Tibbiya College Department of Obstetrics and Gyneacology Kashmir Tibbiya College

Objective To determine the effect of hydroalcoholic extract of Ocimum basilicum Linn. leaves on ovulation, implantation and maintenance of pregnancy in adult female cyclic Wistar rats. Methods Ocimum basilicum leaves extract （364 mg/kg and 624 mg/kg） was screened for its antiovulatory, antiimplantation and abortifacient activities. vaginal smear of each rat was monitored daily during the 15-day treatment of the first experiment. Estimation of cholesterol in ovarian tissue and its histology was carried out to confirm its antiovulatory activity. In the second and third experiments, animals received treatment from 1st to 7th and 8th to 16th day of pregnancy, respectively. The number of implantations and litter size were determined through laparotomy on l Oth and 20th day of pregnancy, respectively in two tests. The treated groups were compared with pain control. Results A significant increase in duration of estrus cycle and diestrus phase was observed （P〈O.O01）. A significant decrease in ovarian weight and notable increase in ovarian tissue cholesterol level was also observed （P〈O. 001）. Weight of uterus in treated group was found to be decreased. Histological report showed presence of large corpora lutea in ovarian parenchyma. Neither antiimplantation nor abortifacient effect was observed in rats treated with both the doses of extract. Conclusion Hydroalcoholic extract of Ocimum basilicum interferes normal ovulation by disrupting the estrus cycle and prolonging diestrus phase thus, has a potential of being developed into a female contraceptive.

关键词： herbal contraceptive ovulation implantation cholesterol estrus cycle vaginal smear rats

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Study on the Estrous Cycle Regularity of Cryopreserved Rat Ovarian Tissues after Heterotopic Transplantation

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Open Journal of Obstetrics and Gynecology 2016年第5期6卷 293-298页

作者： Rumana Jafarey Syed Ali Rehan Shah Jaffri Reproductive Medical Centre Renmin Hospital of Wuhan University Wuhan China Federal Board of Revenue Islamabad Pakistan

Objective: To evaluate the re-initiation of ovarian function in cryopreserved ovarian grafts by means of vaginal smear of transplant rats. Methods: A total of 40 SPF-SD female rats (5 - 6 week-old) were randomly divided into three groups (blank control, castration control and transplant group). Ovaries were removed by surgical procedure then after cryopreservation and thawing procedures the ovarian tissues pushed inside the back muscles gap in transplant group. On the first PO day, vaginal smear collection was daily initiated. After 30 days, the PO day when the estrous cycle was re-initiated was considered for analysis as well as the estrous days and the number of estrous cycles. Results: Normal control group had a regular estrous cycle, while the transplant group had an estrous cycle disorder within first 2 weeks and later 2 weeks after the transplantation while the duration of diestrus cycle lasted longer. At the same time, the castration group had lost the normal estrous cycle, keeping continue in the stage of diestrus. Conclusion: In transplanted animals the re-initiated ovarian function can be predicted with alteration between estrous and diestrus phases with predominant estrous irregularity. Moreover, short autotransplanted graft duration needs time to perfuse by new blood vessels and hormone secretions, so could not directly affect its target organs to function properly.

关键词： Transplantation Cryopreservation Thawing vaginal smear Ovarian Tissue Rats

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