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Impact of microbubble enhanced, pulsed, focused ultrasound on tumor circulation of subcutaneous vx2 cancer

Chinese Medical Journal 2014年第14期127卷 2605-2611页

作者： Li Peijing Zhu Mei Xu Yali Zhao Yang Gao Shunji Liu Zheng Gao Yun-hua Third Mil Med Univ Dept Ultrasound Xinqiao Hosp Chongqing 400037 Peoples R China Gen Hosp Jinan Mil Area Dept Ultrasound Jinan 250000 Shandong Peoples R China Kunming Med Coll Dept Ultrasound Affiliated Hosp 1 Kunming 650032 Yunnan Peoples R China

Background Intravascular microbubble-enhanced acoustic cavitation is capable of disrupting the vascular walls of capillaries and small vessels. This study was designed to investigate the impact of microbubble-enhanced, pulsed and focused ultrasound （MEUS） on the blood perfusion of subcutaneous vx2 tumors in rabbits. Methods Subcutaneous vx2 cancers in twenty New Zealand rabbits were treated by combining high-pressure amplitude, pulsed and focused therapeutic ultrasound （TUS） and intravenous microbubble injections. The TUS transducer was operated with a peak negative pressure of 4.6 MPa and a duty cycle of 0.41%. Controls were subcutaneous vx2 cancers treated with TUS or microbubbles only. Contrast-enhanced ultrasound （CEUS） and intravenous Evans Blue （EB） perfusion were performed to assess the tumor circulation. The tumor microvascular disruption was assessed by histological examination. Results CEUS showed that the tumor circulation almost vanished after MEUS treatment. The average peak grayscale value （GSV） of tumor CEUS dropped significantly from 84.1±22.4 to 15.8±10.8 in the MEUS-treated tumors but no significant GSV changes were found in tumors in the two control groups. The mean tumor EB content of the MEUS-treated tumors was significantly lower than that of the controls. Histological examination found scattered tumor microvascular disruption with intercellular edema after MEUS treatment. Conclusion The tumor circulation of vx2 cancers can be arrested or significantly reduced by MEUS due to microvascular disruption. Chin M~.cl ,I 2014：127 （14）： 2605-2611

关键词： vx2 tumor circulation therapeutic ultrasound microbubble contrast-enhanced ultrasound

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Expression of MMP-2 in residual vx2 liver tumor after transcatheter arterial embolization combined with portal venous embolization in an animal model

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Journal of Interventional Medicine 2020年第4期3卷 167-173页

作者： Ning Wei Ziqiang Wu Dong Lu Jingkun Xiao Chunze Zhou Senlin Chu Weifu Lv Department of Radiology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui230001China Department of Medical Imaging Center The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui230036China

Objective:This study aimed to analyze the effects of transcatheter arterial embolization(TAE)combined with portal venous embolization(PVE)on the expression of MMP-2 in residual vx2 liver tumor tissues,liver function and non-embolic lobe regeneration.Methods:A total of 72 rabbits were randomly divided into Sham,TAE,PVE and TAE+PVE groups(n=18/group).The tissue samples from each group were taken at 6 h,3 days and 7 days after interventional operation,respectively.MMP-2 expression was detected by immunohistochemistry,Real-time PCR,and Western-blotting.The main indicators(such as AST,ATL,and TBIL)of liver function and the volume of non-embolized hepatic lobes were measured in each group after operation.One-way ANOVA and Kruskal-wallis method were used for statistical analysis.Results:The expression of MMP-2 mRNA and protein remained the highest in the Sham group,and the expression of MMP-2 mRNA and protein in TAE,PVE and TAE+PVE groups were successively increased,and the expression of MMP-2 in TAE+PVE group was always significantly higher than TAE group.The AST and ALT levels in each group on day 7 after operation showed a significant declination,and all groups have recovered to the preoperative baseline level and TBIL has a slight fluctuation in each group after operation with no statistical difference.On day 7 after operation,the increasing volume of non-embolized liver lobes in TAE+PVE group showed a more significant effect than those in PVE group,but there was no statistical significance(37.62±1.54 ml VS 36.18±1.15 ml,P=0.881),and its volume was significantly higher than those in the sham group(27.03±1.11 ml).Conclusion:TAE+PVE is considered to be an efficient and safe approach for treating rabbit vx2 liver transplantation tumor,but the expression of MMP-2 increased fastest after TAE+PVE,which might promote tumor cell invasion and metastasis.

关键词： Transcatheter arterial embolization Portal vein embolization Matrix metalloproteinase-2 vx2 tumor Liver regeneration

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Biodegradable magnesium alloy as a new connecting material for iodine-125 brachytherapy:an initial experimental study in a rabbit vx2 model

Biodegradable magnesium alloy as a new connecting material f...

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中国(第七届)肿瘤微创治疗学术大会暨世界影像导引下肿瘤...

作者： Dong Chen1,Guang-feng Duan1,Yan-ling Zhang2,Sheng Peng1 Jian-jun Han1,Chuan-xing Li 1*,Fu-jun Zhang 1* 1.Department of Imaging and Interventional Radiology,Cancer Center of Sun Yat-sen University,Guangzhou,510060,People''s Republic of China 2.School of Biotechnology,Southern Medical University,Guangzhou 510515,People''s Republic of China

＜正＞Objective To evaluate the in vivo degradation characteristics and tissue compatibility of new I125 seed chains connected with the biodegradable magnesium alloy AZ31 in New Zealand rabbits. Methods Thirty New Zealand rabbits were randomly divided into three groups.In group A,magnesium alloy radioactive I125 seeds chains were implanted into vx2 tumors;in group B,magnesium alloy non-radioactive I125 seeds chains were implanted into normal muscle;group C served as an untreated control group.The mass loss of the AZ31 magnesium alloy connecting material was measured in the two groups at different time points after implantation of the I125 seed chains.Morphological and histological changes at the implantation site and in organs were monitored using light microscopy,and seed displacement was assessed using regular X-ray and computed tomography（CT） scanning.Blood and urine samples were collected from all experimental animals to measure changes in magnesium ion concentrations. Results The new 1125 seed chains made with AZ31 magnesium alloy began to degrade during the first week after implantation.On day 21,the degradation rate was 81%in muscle tissue and 83%in tumor tissue;these degradation rates are not statistically significant.Shortly after implantation,a mild local inflammatory response and gas production were induced;the gas disappeared 21 days after implantation.Blood magnesium ion concentrations after implantation were relatively stable,but urine magnesium concentrations increased and fluctuated over a larger range.Pathological inspection of the liver,kidney,heart,and spleen of all animals implanted with 1125 seed chains revealed no significant abnormalities.At 7 days after the implantation of magnesium alloy radioactive 1125 seed chains into tumors,the connecting material showed good connecting and fixing function.At 21 days after implantation,the seeds had separated from each other,displacement had occurred,and the radioactive seeds had aggregated in concordance with tumor shrinkage. Conclusion 1125 seed chains

关键词： I125 radioactive stranded seeds biodegradable magnesium alloy vx2 tumor biocompatibility

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