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Distinct regulatory mechanism of immunoglobulin gene transcription in epithelial cancer cells

Cellular & Molecular Immunology 2010年第4期7卷 279-287页

作者： Xiaohui Zhu Lina Wu Li Zhang Peng Hao Shuai Zhang Jing Huang Jie Zheng Yinan Liu Wenjun Li Yingmei Zhang Chunyan Zhou Youhui Zhang C Cameron Yin Xiaoyan Qiu Peking University Center for Human Disease Genomics BeijingChina Department of Biochemistry School of Basic Medical SciencePeking UniversityBeijingChina Department of Immunology Cancer InstituteChinese Academy of Medical Science and Peking Union Medical CollegeBeijingChina Department of Hematopathology University of Texas M.D.Anderson Cancer CenterHoustonTXUSA These authors contributed equally to this work

The restriction of immunoglobulin(Ig)expression to B lymphocytes is well ***,several reports have confirmed that the Ig gene can be expressed in many non-B cancer cells and/or some normal *** aim is to determine whether the Ig gene promoter can be activated in non-B cancer cells and to identify the regulatory mechanism for Ig gene *** results show that the Ig promoter of vh4-59 was activated in several non-B cancer cell ***,two novel positive regulatory elements,an enhancer-like element at 2800 to 2610 bp and a copromoter-like element at 2610 to 2300 bp,were identified in two epithelial cancer cell lines,HeLa S3 and *** octamer element(59-ATGCAAAT-39)located in the Ig promoter,a crucial element for B-cell-derived Ig gene transcription,was also very important for non-B-cell-derived Ig gene *** importantly,we confirmed that octamer-related protein-1(Oct-1),but not Oct-2,was a crucial transcriptional factor for Ig gene transcription due to its ability to bind to the octamer element of the Ig promoter in epithelial cancer *** results suggested the presence of a distinct regulatory mechanism for Ig gene expression in non-B cancer cells.

关键词： Ig gene transcription Oct-1 promoter transcription regulation vh4-59

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