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Protective effect of Shouwu Yizhi decoction against vascular dementia by promoting angiogenesis

Chinese Journal of Natural Medicines 2017年第10期15卷 740-750页

作者： YANG Xiao-Ni LI Chang-Sheng CHEN Chao TANG Xiao-Yong CHENG Guang-Qing LI Xia Department of Tranditional Chinese Medicine Shandong Qianfoshan Hospital Jinan 250014 China Department of Internal Medicine Ⅷ Shandong Tumor Hospital Jinan 250014 China Key Laboratory for Tumor Immunology and Traditional Chinese Medicine Immunology Institute of Basic Medicine Shandong Academy of Medical Sciences Jinan 250062 China

Shouwu is a traditional Chinese medicine(TCM)with neuroprotective *** Yizhi decoction(SYD)was designed based on TCM ***,little is known about the roles of SYD in Vascular dementia(Va D).The present study aimed to evaluate the potential effects of SYD on the vascular cognitive impairment and explore the underlying mechanism by establishing focal cerebral ischemia/reperfusion(I/R)rat model to induce Va *** administration(54 mg·kg^(-1))for 40 days obviously improved the vascular cognitive impairment in the middle cerebral artery occlusion(MCAO)rats as evidenced by the declined neurological deficit score and shortened escape latency via neurological deficit assessment and Morris water maze ***,SYD decreased neuron damage-induced cell death and ameliorated the ultrastructure of endothelial cells in the MCAO rats,thereby alleviating Va ***,SYD caused increases in the expression of vascular endothelial growth factor(vegf),CD34 and CD31,compared with the MCAO rats in coronal ***,the expression level of mi R-210 was elevated significantly after SYD administration,compared with the vehicle rats(Pnotch 4 at both m RNA and protein levels was upregulated remarkably along with the notably downregulated DLL4 expression under SYD administration compared with the vehicle rats(Pvegf-induced mi R210 expression to activate notch pathway,and further alleviated neuron damage and ameliorated the ultrastructure of endothelial cells in the MCAO rats,ultimately enhancing the cognition and memory of MCAO ***,our findings preliminarily identified the effect and the mechanism of action for SYD on Va D in *** could be a potential candidate in treatment of Va D.

关键词： Shouwu Yizhi decoction Vascular dementia Angiogenesis vegf-notch signaling pathway

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