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Enhanced angiogenesis by the hyaluronic acid hydrogels immobilized with a vegf mimetic peptide in a traumatic brain injury model in rats

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Regenerative Biomaterials 2019年第6期6卷 325-334页

作者： Jiaju Lu Fengyi Guan Fuzhai Cui Xiaodan Sun Lingyun Zhao Ying Wang Xiumei Wang State Key Laboratory of New Ceramics and Fine Processing Key Laboratory of Advanced Materials of Ministry of EducationSchool of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Beijing Center of Neutral Regeneration and Repair Key Laboratory for Neurodegenerative Disease of the Ministry of EducationCapital Medical UniversityBeijing 100069China

Angiogenesis plays an important role in brain injury repair,which contributes to the reconstruction of regenerative neurovascular niche for promoting axonal regeneration in the lesion *** a major component of developing brain extracellular matrix,hyaluronic acid(HA)has attracted more attention as a supporting matrix for brain *** the present study,HA-KLT hydrogel was developed via modifying HA with a vegf mimetic peptide of KLT(KLTWQELYQLKYKGI).The characterization of the hydrogel shows that it could provide a porous,three-dimensional scaffold structure,which has a large specific surface area available for cell adhesion and *** with the unmodified HA hydrogel,the HA-KLT hydrogel could effectively promote the attachment,spreading and proliferation of endothelial cells in ***,the pro-angiogenic ability of hydrogels in vivo was evaluated by implanting them into the lesion cavities in the injured rat *** results showed that the hydrogels could form a permissive interface with the host tissues at 4 weeks after ***,they could efficiently inhibit the formation of glial scars at the injured *** HA-KLT hydrogel could significantly increase the expression of endoglin/CD105 and promote the formation of blood vessels,suggesting that HA-KLT hydrogel promoted angiogenesis in ***,the HA-KLT hydrogel has the potential to repair brain defects by promoting angiogenesis and inhibiting the formation of glial-derived scar tissue.

关键词： traumatic brain injury hyaluronic acid angiogenesis vegf mimetic peptide

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