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Construction of millimeter-scale vascularized engineered myocardial tissue using a mixed gel

Regenerative Biomaterials 2024年第3期3卷 56-67页

作者： Ming Ke Wenhui Xu Yansha Hao Feiyang Zheng Guanyuan Yang Yonghong Fan Fangfang Wang Zhiqiang Nie Chuhong Zhu Department of Anatomy Third Military Medical UniversityChongqing 400038China State Key Laboratory of Trauma Burn and Combined InjuryChongqing 400038China Department of Plastic and Aesthetic Surgery Southwest HospitalThird Military Medical UniversityChongqing 400038China Engineering Research Center of Tissue and Organ Regeneration and Manufacturing Ministry of EducationChongqing 400038China

Engineering myocardium has shown great clinal potential for repairing permanent myocardial ***,the lack of perfusing blood vessels and difficulties in preparing a thick-engineered myocardium result in its limited clinical *** prepared a mixed gel containing fibrin(5 mg/ml)and collagen I(0.2 mg/ml)and verified that human umbilical vein endothelial cells(HUVECs)and human-induced pluripotent stem cell-derived cardiomyocytes(hiPSC-CMs)could fom microvascular lumens and myocardial cell clusters by harnessing the low-hardness and hyperelastic characteristics of ***-CMs and HUVECs in the mixed gel formed self-organized cell clusters,which were then cultured in different media using a three-phase *** successfully constructed vascularized engineered myocardial tissue had a spherical structure and final diameter of *** tissue exhibited autonomous beats that occured at a frequency similar to a normal human heart *** internal microvascular lumen could be maintained for 6 weeks and showed good results during preliminary surface re-vascularization in vitro and vascular remodeling in *** summary,we propose a simple method for constructing vascularized engineered myocardial tissue,through phased cultivation that does not rely on high-end manufacturing equipment and cutting-edge preparation *** constructed tissue has potential value for clinical use after preliminary evaluation.

关键词： engineered myocardium vascularized hiPSC-CM HUVEC fibrin

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SUPEKFICIAL RADIA L BRANCH GRAFT WITH vascularized PEDICLE TO REPAIRLONGDEFECTOFTHERADIALNERVE：AREPORTOF8CASE

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中华创伤杂志 1994年第6期 305-306页

作者：倪爱民陈中伟

ＳＵＰＥＫＦＩＣＩＡＬＲＡＤＩＡＬＢＲＡＮＣＨＧＲＡＦＴＷＩＴＨＶＡＳＣＵＬＡＲＩＺＥＤＰＥＤＩＣＬＥＴＯＲＥＰＡＩＲＬＯＮＧＤＥＦＥＣＴＯＦＴＨＥＲＡＤＩＡＬＮＥＲＶＥ：ＡＲＥＰＯＲＴＯＦ８ＣＡＳＥＳＮｉＡｉ－ｍｉ... 详细信息

ＳＵＰＥＫＦＩＣＩＡＬＲＡＤＩＡＬＢＲＡＮＣＨＧＲＡＦＴＷＩＴＨＶＡＳＣＵＬＡＲＩＺＥＤＰＥＤＩＣＬＥＴＯＲＥＰＡＩＲＬＯＮＧＤＥＦＥＣＴＯＦＴＨＥＲＡＤＩＡＬＮＥＲＶＥ：ＡＲＥＰＯＲＴＯＦ８ＣＡＳＥＳＮｉＡｉ－ｍｉｎ倪爱民ＣｈｅｎＺｈｏｎｇ－ｗｅｉ...

关键词： CASE 陈中伟 BRANCH GRAFT PEDICLE RADIA L SUPEKFICIAL TO vascularized WITH

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PERIPHERAL NERVE REPAIR IN RATS USING vascularized FROZEN IN-SITU MUSCLE AUTOGRAFT

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中华创伤杂志 1997年第4期13卷 73-77页

作者：王岩朱盛修解放军总医院北京香港中文大学香港

ＰＥＲＩＰＨＥＲＡＬＮＥＲＶＥＲＥＰＡＩＲＩＮＲＡＴＳＵＳＩＮＧＶＡＳＣＵＬＡＲＩＺＥＤＦＲＯＺＥＮＩＮ┐ＳＩＴＵＭＵＳＣＬＥＡＵＴＯＧＲＡＦＴＷＡＮＧＹａｎ（王岩）１，ＺＨＵＳｈｅｎｇ－ｘｉｕ（朱盛修）１，ＨＵＮＧ... 详细信息

ＰＥＲＩＰＨＥＲＡＬＮＥＲＶＥＲＥＰＡＩＲＩＮＲＡＴＳＵＳＩＮＧＶＡＳＣＵＬＡＲＩＺＥＤＦＲＯＺＥＮＩＮ┐ＳＩＴＵＭＵＳＣＬＥＡＵＴＯＧＲＡＦＴＷＡＮＧＹａｎ（王岩）１，ＺＨＵＳｈｅｎｇ－ｘｉｕ（朱盛修）１，ＨＵＮＧＬＫ２，ＬＥＵＮＧＰＣ２１．Ｄｅｐ...

关键词：王岩 USING RATS MUSCLE REPAIR vascularized IN-SITU FROZEN AUTOGRAFT

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Reviewing immunosuppressive regimens in animal models for vascularized composite allotransplantation

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Plastic and Aesthetic Research 2018年第3期5卷 17-26页

作者： Aline Yen Ling Wang Charles Yuen Yung Loh Center for vascularized Composite Allotransplantation Chang Gung Memorial HospitalTaoyuan 333Taiwan St Andrew’s Center for Burns and Plastic Surgery Chelmsford CM1 7THUK

The development of vascularized composite allotransplantation (VCA) and its clinical need has led to the need for more animal models to study and perform the research required to further this specialty in terms of functional recovery and immunomodulatory improvements. Much of the animal models are reported in individual series in the literature but there has not been a review as such of these models. Here we present a compilation of the animal models reported in the literature thus far in VCA. A comprehensive review of the literature was performed for any studies which involved the use of animal models in various aspects of VCA research. The models were organized according to the type of VCA transplant, whether they were orthotopic or heterotopic, immunosuppressive regimen each study used and investigation purpose. Twenty-one facial transplant models were reported, 3 abdominal wall transplants, 4 penile transplantations, 21 uterus transplantations, 12 hindlimb transplantations and 4 myocutaneous flap transplantation animal models were reported. Primates, swine, rats, mice, rabbits, sheep and dog animal models in VCA were also reported. The most used immunosuppressive drugs are calcineurin inhibitor such as cyclosporin A and tacrolimus in these VCA animal models. They can significantly suppress lymphocyte function by blocking the phosphatase activity of calcineurin of lymphocytes. They are sometimes used combined with mycophenolate mofetil or steroids or antilymphocyte serum. The review of existing animal models will allow further research to be focused in other areas of VCA where there is a current paucity of literature. The immunosuppressive regimens used in each animal model can also be reviewed to determine which regimen works in which type of animal model which will save time and resources for future research.

关键词： Animal models vascularized composite allotransplantation immunosuppressive regimens

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Early debridement and delayed primary vascularized cover in forearm electrical burns: A prospective study

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World Journal of Critical Care Medicine 2016年第4期5卷 228-234页

作者： Aniruddh Mene Gautam Biswas Atul Parashar Anish Bhattacharya Department of Plastic Surgery Post Graduate Institute of Medical Education and Research Department of Nuclear Medicine Post Graduate Institute of Medical Education and Research

AIM To look into the management options of early debridement of the wound, followed by vascularized cover to bring in fresh blood supply to remaining tissue in electrical burns. METHODS A total of 16 consecutive patients sustaining full thickness forearm burns over a period of one year were included in the study group. Debridement was undertaken within 48 h in 13 patients. Three patients were taken for debridement after 48 h. Debridement was repeated within 2-4 d after daily wound assessment and need for further debridement. RESULTS On an average two debridements(range 1-4) was required in our patients for the wound to be ready for definitive cover. Interval between each debridement ranged from 2-18 d. Fourteen patients were provided vascularized cover after final debridement(6 free flaps, 8 pedicled flaps). Functional assessment of gross hand function done at 6 wk, 2 mo, 3 mo and 6 mo follow-up. CONCLUSION High-tension electrical burns lead to significant morbi-dity. These injuries are best managed by early decompression followed by multiple serial debridements. The ideal timing of free flap coverage needs further investigation.

关键词： Early debridement vascularized cover Electrical burns Forearm

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Proximal femur reconstruction using a vascularized fibular epiphysis within a cadaveric femoral allograft in a child with Ewing sarcoma: a case report

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Plastic and Aesthetic Research 2017年第11期4卷 209-214页

作者： Michelle YSeu Allison Haley Brian HCho Hannah MCarl Tobias JBos Aladdin HHassanein Alison LWong Carol DMorris Justin MSacks Department of Plastic and Reconstructive Surgery Johns Hopkins University School of MedicineBaltimoreMD21205USA Department of Plastic and Reconstructive Surgery Dalhousie University School of MedicineHalifaxNova Scotia B3H4R2Canada Department of Orthopedic Surgery Johns Hopkins University School of MedicineBaltimoreMD21205USA

Periarticular reconstruction of appendicular bones in skeletally immature patients after tumor resection is a surgical challenge that requires a multidisciplinary approach. The authors present a case of Ewing sarcoma of the proximal femur in an 8-year old girl treated with wide resection of the primary tumor and reconstruction using a vascularized fibula epiphyseal autograft within a cadaveric femoral allograft. The native femoral head was preserved to restore articular anatomy. Postoperative course was without complications. This report demonstrates the use of a vascularized fibula autograft within a cadaveric femoral allograft to optimize growth potential and joint durability in a pediatric patient.

关键词： Femur reconstruction vascularized fibula autograft Ewing sarcoma

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Reconstruction Using a Free vascularized Fibular Graft after Frozen Autograft Reconstruction for Osteosarcoma of the Distal Tibia: A Case Report

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Modern Plastic Surgery 2013年第1期3卷 47-50页

作者： Seigo Suganuma Kaoru Tada Norio Yamamoto Toshiharu Shirai Katsuhiro Hayashi Akihiko Takeuchi Hiroyuki Tsuchiya Department of Orthopaedic Surgery Graduate School of Medical Science Kanazawa University Kanazawa Japan

Recently we have been performing biological reconstruction for malignant bone tumors of the extremities using frozen autografts. Here we present a case treated with free vascularized fibular graft (FVFG) after this method. A 23-year-old man developed osteosarcoma in his left distal tibia. There was nonunion after frozen autograft reconstruction, which we treated with FVFG. Twenty-four months later, bridging between the host bone and the frozen autograft was achieved. Our department has achieved bone union in almost all cases, but we sometimes encounter cases of nonunion after this method because of delayed blood supply. In these instances, reconstruction using FVFG may represent an attractive choice for salvage treatment.

关键词： Free vascularized Fibular Graft Frozen Autograft Reconstruction Malignant Bone Tumor

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AN ANATOMICAL STUDY OF vascularized PLANTARIS TENDON GRAFT

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Medical Bulletin of Shanghai Jiaotong University 1999年第2期20卷 98-99,112页

作者：李青峰徐靖宏张涤生

Objective To find out a new vascularized donor tendon for grafting. Methods A detailed anatomical study olplantaris tendon and its vascular connection with the posterior tibial artery was carried out in 16 legs of 8 fresh adult cadavers, and histological examination of the vascular pattern was also performed. Results There exists a close vascular connection between the crural las cial - linked part of the plantaris tendon and the posterior tibial artery. The blood supply of the plantaris tendon is provided by 2~4 transfasctal branches of the posterior tibial artery in the lower- middle part of leg. Out of these branches, one or two anastomosable arteries (more than 1.0cm) together with veins constantly emerge 5~8cm from the insertion of the plantaris tendon. A strip of Achilles tendon can be a substitute in case of plantaris missing tendon. The histotwical observation demonstrates the reliable vascularity of the paratenon and crural fascial. Conclusion The plantaris tendon is a better option of donor vascularized tendon. A composite tendofascial flap with vascularized pedicle from the posterior tibial artery or its branches is supposed to be an advisable method for vascularized tendon gralt clinically. In the case of the plantaris missing, a strip of Achilles tendon should be the second choice.

关键词： tendon transplantation vascularized plantaris tendon

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Live Fibular Graft for the Treatment of Long Bone Tumors in Children

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Journal of Cancer Therapy 2017年第3期8卷 225-233页

作者： Seung-Koo Rhee Mohammed Einayet Abdelhameed Chi-Hoon Ahn Cheol-U Kim Department of Orthopaedic Surgery Bone & Joint Tumor Division Daejeon Sun Medical Center Daejeon Korea Department of Orthopaedic Surgery Sharg Alneel Hospital Khartom Sudan

Purposes: We would like to inform the characteristics of recurred osteo-fibrous dysplasia (OFD), and also the possible use of vascularized composite autograft and allografts (VCA) combined with live fibular graft (LFG) for the treatment of aggressive benign bone tumor and osteogenic sarcomas in children. Materials and Methods: We reviewed one boy with recurred OFD after LFG, and other four children with osteogenic sarcoma in long bone which was treated with LFG and VCA, and followed them for average 9 years (3 - 14 years). Survival of the LFG and VCA was estimated by the ISOLS Functional Radiologic Scoring System, but not with Kaplans-Meier’s scoring system because of a small series of case reports. Results: All succeed after surgeries initially, but the cause of recurrence of OFD was still unclear, and one girl with osteogenic sarcoma on distal femur died with skip and lung metastasis, 4 years after surgeries. Conclusions: The causes of recurred OFD are not found thru pathologic studies of our patient, but we believe the multifocal origin of tumor cells even on the adjacent soft tissues in OFD is one of the causes. The excised long bone tumor is recycled by pasteurization or autoclaving, or allograft, then LFG, and neo-adjuvant chemotherapy would be one of elective surgery for the treatment of malignant long bone tumors in children. The LFG into recycled autograft or allograft bone is difficult to perform simultaneously, but very effective to increase more earlier regenerative vascularities and also the stabilities of the dead bones in children.

关键词： Live Fibular Graft vascularized Composite Allograft or Autograft Osteofibrous Dysplasia Osteogenic Sarcoma Children

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Long-Term Follow-Up of Microsurgical Reconstruction for Pelvic Tumor Focusing on Spinal Deformity and Quality of Life

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Journal of Cancer Therapy 2014年第4期5卷 354-362页

作者： Soichi Ejiri Shin-ichi Kikuchi Takahiro Tajino Ryoichi Kawakami Michiyuki Hakozaki Shin-ichi Konno Department of Orthopaedic Surgery Fukushima Medical University School of Medicine Fukushima Japan

Background: To provide patients with a superior quality of life (QOL) after their pelvic tumor resection, ensuring the stability of the trunk as well as satisfactory lower extremity function is important. Although microsurgical reconstructions for the pelvic ring and hip are used clinically, the details of postoperative long-term spinal deformity and QOL remain unclear. Methods: The patients were 66- and 43-year-old men and a 43-year-old woman. The mean postoperative follow-up period was 134 months. The surgical procedures performed on these patients were: pelvic ring reconstruction using a double-barreled free vascularized fibular graft (FVFG) in Patient 1;simultaneous pelvic ring reconstruction using FVFG and hip arthrodesis in Patient 2;and latissimus dorsi free flap without pelvic ring reconstruction in Patient 3. As indicators of spinal deformity, we measured the Cobb angle, thoracic kyphosis angle, lumbar lordosis angle, pelvic angle on the sagittal plane, and sagittal plane balance using whole spine radiography. To assess the patients’ QOL, we examined the International Society of Limb Salvage (ISOLS) score, the Roland-Morris Disability Questionnaire (RDQ), activities of daily living (ADL) satisfaction using a visual analogue scale (VAS), and the SF-36. Results: Spinal alignment in the frontal plane worsened in order from Patient 1 to 3. Spinal alignment and pelvic tilt in the sagittal plane were at appropriate levels in Patients 1 and 2. The trunk tilt in the sagittal plane was at an appropriate level only in Patient 1. In the QOL assessment, the function of the affected limb worsened in order from Patient 1 to 3. RDQ scores were lower than the national norm in Patients 2 and 3. With respect to ADL satisfaction and the SF-36, Patient 3 had a markedly low VAS, physical functioning, role-physical, and role-emotional scores. Conclusion: In the long-term clinical course after pelvic tumor resection, in order to obtain satisfactory spinal alignment and QOL, pelvi

关键词： Pelvic Tumor Pelvic Ring Reconstruction Quality of Life Spinal Deformity vascularized Fibular Graft

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