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The delay, symptoms, and survival of Ivorian adolescent girls and young adults with uterine cervical cancer

Gynecology and Obstetrics Clinical Medicine 2021年第3期1卷 153-159页

作者： Edele Kacou Aka Apollinaire Horo Mohamed Fanny Abdoul Koffi Luc Olou Perel Konan Ana Toure-Ecra Mamourou Kone Universite Felix Houphou et Boigny(FHB) AbidjanBPV 34AbidjanCote d'Ivoire Centre Hospitalier Universitaire de Yopougon-Abidjan Service de Gynecologie-Obstetrique 21BP 632AbidjanCote d'Ivoire

Objective:To generate data on the nature and duration of cervical cancer symptoms,risk factors for delayed consultation,and diagnosis of adolescent and young adult groups in Cote d'***:This is a hospital-based cross-sectional study,conducted from July 2012 to May 2018,at the Department of Gynecology of the Yopougon teaching hospital in Cote d’*** inclusion criteria were those who were under 40 years of age at the time of diagnosis with oral and written *** whose information was more than 10%insufficient for the standards were excluded from the *** survey files standardized anonymous pre-established data collected using medical records followed by phone ***:The average age of the participants was 34±4.95 years with a minimum of 21 *** mean parity per woman was 3.49±3.***.34.9%were HIV *** median patient delay was 122 days with a long delay in 84.62%of *** median time to total diagnosis was 209 days with a longer total delay in diagnosis of 87.18%.41%of patients honored their treatment,68.75%of which had received surgery,and 31.25%of which had received *** 5-year survival rate was 65%.Conclusion:The Ivorian health system must focus on primary and secondary prevention,the only guarantee to decrease the morbidity and mortality indicators linked to cervical cancer.

关键词： uterine cervical neoplasm Adolescent Survival Delay

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Relationship between Circulating Plasma Galectin-3 Levels and T-Cell Activation during cervical Cancer Chemotherapy

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Open Journal of Immunology 2023年第1期13卷 14-31页

作者： Folly M. Gaba Maïmouna Diop Doudou G. M. Niang Sidy Ka Doudou Diouf Moussa Ndour Comlan J. G. Montcho Moustapha Mbow Babacar Faye Rokhaya N. Diallo Maguette S. Niang Ahmadou Dem Babacar Mbengue Alioune Dieye Immunology Department Faculty of Medicine Pharmacy and Odontology University of Cheikh Anta Diop Dakar Senegal Immunology Laboratory Aristide Ledantec Hospital (HALD) Dakar Senegal Oncology Department Juliot Curie Institute Aristide Ledantec Hospital (HALD) Dakar Senegal Human Genetic Department Faculty of Medicine Pharmacy and Odontology University of Cheikh Anta Diop Dakar Senegal

Objective: Despite the existence of several therapeutic strategies, the management of cervical cancer remains challenging. Our region has very little data on the interaction between the immune system and the clinical response to chemotherapy. This work examines plasma levels of galectin-3 (Gal-3) and percentages of activated T cells in patients with cervical cancer treated with chemotherapy and investigates if there is a relationship between the rates of these two elements. Methods: We compared data from 37 patients with cervical cancer undergoing chemotherapy and 42 controls with normal cervical cytology. Plasma Gal-3 concentrations were assessed by ELISA and expression of activation markers by T cells (CD69 and HLA-DR) was assessed by flow cytometry at three different time points during chemotherapy. Results: Our results showed that patients had a significantly higher concentration of Gal-3 compared to controls (4.025 vs. 1.340, p 0.001), similarly, they had a significantly high percentage of activated lymphocytes (2.610 vs. 0.731;p 0.0001). According to the response to treatment, patients with no response to treatment had a lower concentration of circulating Gal-3 but had approximately the same percentage of activated CD4 and CD8 lymphocytes as patients with a partial or total response. In addition, we found a positive correlation between the Gal-3 level and CD4 T cells expressing the activation marker CD69 (p 0.05;rho = 0.44). Conclusion: In conclusion, our results show that there would be a relationship between circulating galectin-3 and the percentage of peripheral CD4+CD69+ cells in cervical cancer.

关键词： uterine cervical neoplasm Chemotherapy Galectin 3 T-Lymphocytes Activation

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Impact of sites versus number of metastases on survival of patients with organ metastasis from newly diagnosed cervical cancer

Impact of sites versus number of metastases on survival of p...

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2019年浙江省妇科肿瘤学学术大会

作者： Zhuomin Yin Huarong Tang Li Li Juan N Shuhui Yuan Hanmei Lou Department of Gynecologic Radiation Oncology Zhejiang Cancer Hospital

Objective:The aim of this study was to investigate the potential associations of the sites and the number of specific metastases with survival in patients newly diagnosed with cervical ***:Medical records of patients with organ metastases of newly diagnosed cervical cancer at Zhejiang Cancer Hospital from October 2006 to December 2016 were reviewed *** times were compared using the Kaplan-Meier *** associated with survival were identified using univariate and multivariate Cox proportional hazards ***:A total of 99 patients with newly diagnosed organ metastatic cervical cancer were *** follow-up was 11.6 months(range,0.5-114.7 months).Median overall survival(OS) time was 11.7 months from diagnosis,with 1-,2-,and 5-year OS rates of 48.2%,22.8%,and 12.6%,*** most common site of organ metastasis was bone(36.8%),followed by lung(32.8%) and liver(24%).In univariate analysis,OS rates were better for bone metastasis than visceral metastasis(P=0.013),oligometastasis than non-oligometastasis(P=0.003)and single organ metastasis than multiple organ metastases(P=0.016),while that for liver metastasis was poorer than non-liver metastases(Pcervical cancer,with liver metastasis signifying particularly poor overall *** treatments should be administered to patients depending on the specific metastatic sites.

关键词： uterine cervical neoplasm survival organ metastasis metastatic site number of metastases

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