检索结果-南通市图书馆

Icaritin inhibits the progression of urothelial cancer by suppressing PADI2-mediated neutrophil infiltration and neutrophil extracellular trap formation

引用

Acta Pharmaceutica Sinica B 2024年第9期14卷 3916-3930页

作者： Zezhong Mou Yiling Chen Jinzhong Hu Yun Hu Lujia Zou Xinan Chen Shenghua Liu Qiuping Yin Jian Gong Shuchen Li Shanhua Mao Chenyang Xu Haowen Jiang Department of Urology Huashan HospitalFudan UniversityShanghai 200040China Fudan Institute of Urology Fudan UniversityShanghai 200040China National Clinical Research Center for Aging and Medicine Fudan UniversityShanghai 200040China

Tumor relapse and metastasis are the major causes of mortality associated with urothelial *** the tumor microenvironment,negative regulatory molecules and various immune cell subtypes suppress antitumor *** inflammatory microenvironment,associated with neutrophils and neutrophil extracellular traps(NETs),promotes tumor ***,no drugs are currently available to specifically inhibit neutrophils and *** this study,we first demonstrated that icaritin(ICT),a Chinese herbal remedy that is a first-line treatment for advanced and incurable hepatocellular carcinoma,reduces NETs caused by suicidal NETosis and prevents neutrophil infiltration in the tumor ***,ICT binds to and inhibits the expression of PADI2 in neutrophils,thereby suppressing PADI2-mediated histone ***,ICT inhibits ROS generation,suppresses the MAPK signaling pathway,and inhibits NET-induced tumor ***,ICT inhibits tumoral PADI2-mediated histone citrullination,which consequently suppresses the transcription of neutrophil-recruiting genes such as GM-CSF and *** downregulation of IL-6 expression,in turn,forms a regulatory feedback loop through the JAK2/STAT3/IL-6 *** a retrospective study of clinical samples,we found a correlation between neutrophils,NETs,UCa prognosis,and immune *** ICT with immune checkpoint inhibitors may have synergistic *** summary,our study demonstrated that ICT could be a novel inhibitor of NETs and a novel UCa treatment.

关键词： Icaritin Neutrophil Neutrophil extracellular trap PADI2 urothelial cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Potential role of transmembrane 9 superfamily member 1 as a biomarker in urothelial cancer

引用

World Journal of Clinical Oncology 2024年第8期15卷 965-967页

作者： Alvaro Pinto Abrahams Ocanto Felipe Couñago Department of Medical Oncology University Hospital La PazPaseo Castellana 261Madrid 28046Spain Department of Radiation Oncology GenesisCareHospital Universitario San Francisco de AsísMadrid 28002Spain Department of Radiation Oncology GenesisCareVithas La Milagrosa University HospitalMadrid 28010Spain National Director GenesisCare Madrid 28043Spain

Bladder cancer is a urological tumor with high rates of recurrence despite recent advances in novel *** proteins involved in the molecular mechanisms are currently an enigma,especially the transmembrane 9 superfamily member 1 which has an unclear *** et al published the function and mechanism of this protein,and showed that it could participate in the proliferation,migration and invasion of tumor cells in bladder cancer,therefore treatments directed against this protein may be beneficial in avoiding this condition.

关键词： Bladder cancer Transmembrane 9 superfamily member 1 Biomarker urothelial cancer Protein

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Increased incidence of urothelial cancer in chronic renal insufficiency

Increased incidence of Urothelial cancer in chronic renal in...

引用

第十三届全国泌尿外科学术会议暨第八届全球华人泌尿外科学术会议

作者： HanZhong Li,Ming Yuan, Ming Xia, Weigang Yan. Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730

Background: Patients with the chronic renal failure (CRF) have a high incidence of malignancy, particularly develop urothelial cancer. Uremia induces a remarkable suppression of immune status. Multiple underlying rena... 详细信息

关键词： Chronic renal insufficiency Chronic renal failure Neoplasia Aristolochic acid urothelial cancer Chinese-herb nephropathy

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：