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Serum albumin complexed with ellagic acid from pomegranate peel and its metabolite urolithin b

Food bioscience 2022年第2期46卷 1029-1039页

作者： Peiyu Xue Guangjie Zhang Hongmei Zhao Wencheng Wang Jie Zhang Li Ren School of biology and Food Engineering Anyang Institute of TechnologyAnyang455000China School of Life Sciences Jilin UniversityChangchun130012China College of Food Science and Engineering Jilin UniversityChangchun130062China

As one of fruit waste by-products,the pomegranate peel is rich in bioactive compounds such as ellagic acid.Ellagic acid and its main gut microbial metabolite urolithin b have been reported to exhibit numerous biological activities and widely used as dietary supplements in the past decades.Interaction of these two compounds to serum albumin(SA)might affect their metabolism,efficacy,and body distribution.The interaction of ellagic acid and urolithin b with SA was investigated and bSA interference on the anti-cancer activity of these two compounds was also evaluated.Results of spectra experiments showed that ellagic acid and urolithin b could form complexes with bovine serum albumin(bSA)and urolithin b has a higher binding force and number of binding sites than ellagic acid when forming a complex with bSA.The results of molecular docking and molecular dynamics simulations suggested that ellagic acid and urolithin b tended to bind in site I rather than site II.The MTT assay results indicated that the IC_(50) value of ellagic acid decreased from 123.58μM to 55.91μM,while the IC_(50) value of urolithin b decreased from 83.67μM to 47.40μM.Ellagic acid and urolithin b can form complexes with serum albumin and the anti-cancer activity of ellagic acid and urolithin b was enhanced when combined with bSA.

关键词： Ellagic acid urolithin b Serum albumin Anti-cancer activity

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