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The inflammatory microenvironment and the urinary microbiome in the initiation and progression of bladder cancer

Genes & Diseases 2021年第6期8卷 781-797页

作者： Xingxing Huang Ting Pan Lili Yan Ting Jin Ruonan Zhang Bi Chen Jiao Feng Ting Duan Yu Xiang Mingming Zhang Xiaying Chen Zuyi Yang Wenzheng Zhang Xia Ding Tian Xie Xinbing Sui Department of Medical Oncology the Affiliated Hospital of Hangzhou Normal UniversityCollege of MedicineHangzhou Normal UniversityHangzhouZhejiang Province310015PR China College of Pharmacy School of MedicineHangzhou Normal UniversityHangzhouZhejiang Province311121PR China Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines Engineering Laboratory of Development and Application of Traditional Chinese MedicinesCollaborative Innovation Center of Traditional Chinese Medicines of Zhejiang ProvinceHangzhou Normal UniversityHangzhouZhejiang Province311121PR China School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing100029PR China

Accumulating evidence suggests that chronic inflammation may play a critical role in various malignancies,including bladder *** hypothesis stems in part from inflammatory cells observed in the urethral *** inflammation may drive neoplastic transformation and the progression of bladder cancer by activating a series of in-flammatory molecules and ***,it has been shown that the microbiome also plays an important role in the development and progression of bladder cancer,which can be mediated through the stimulation of chronic *** effect,the urinary microbiome can play a role in establishing the inflammatory urethral microenvironment that may facilitate the development and progression of bladder *** other words,chronic inflammation caused by the urinary microbiome may promote the initiation and progression of bladder ***,we provide a detailed and comprehensive account of the link between chronic inflammation,the microbiome and bladder ***,we highlight that targeting the urinary microbiome might enable the development of strategies for bladder cancer prevention and personalized treatment.

关键词： Bladder cancer Carcinogenesis Inflammatory microenvironment Pathogenesis Progression urinary microbiome

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Metabolic syndrome and the urinary microbiome of patients undergoing percutaneous nephrolithotomy

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Asian Journal of Urology 2024年第2期11卷 316-323页

作者： Ryan A.Dornbier Chirag P.Doshi Shalin C.Desai Petar Bajic Michelle Van Kuiken Mark Khemmani Ahmer V.Farooq Larissa Bresler Thomas M.T.Turk Alan J.Wolfe Kristin G.Baldea Loyola University Medical Center Department of UrologyMaywoodILUSA Loyola University Chicago Department of Microbiology and ImmunologyMaywoodILUSA

Objective:To identify possible stone-promoting microbes,we compared the profiles of microbes grown from stones of patients with and without metabolic syndrome(MetS).The association between MetS and urinary stone disease is well established,but the exact pathophysiologic relationship remains *** evidence suggests urinary tract dysbiosis may lead to increased nephrolithiasis ***:At the time of percutaneous nephrolithotomy,bladder urine and stone fragments were collected from patients with and without *** sample types were subjected to expanded quantitative urine culture(EQUC)and 16 S ribosomal RNA gene ***:Fifty-seven patients included 12 controls(21.1%)and 45 MetS patients(78.9%).Both cohorts were similar with respect to demographics and non-MetS *** controls had uric acid stone *** EQUC,bacteria were detected more frequently in MetS stones(42.2%)compared to controls(8.3%)(p=0.041).Bacteria also were more abundant in stones of MetS patients compared to *** validate our EQUC results,we performed 16 S ribosomal RNA gene *** 12/16(75.0%)sequence-positive stones,EQUC reliably isolated at least one species of the sequenced *** were detected in both“infectious”and“non-infectious”stone ***:Bacteria are more common and more abundant in MetS stones than control *** findings support a role for bacteria in urinary stone disease for patients with MetS regardless of stone composition.

关键词： Nephrolithiasis Urolithiasis Metabolic syndrome urinary microbiome Percutaneous nephrolithotomy

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