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Nitro-PAH exposures of occupationally-exposed traffic workers and associated urinary 1-nitropyrene metabolite concentrations

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Journal of Environmental Sciences 2016年第11期28卷 213-221页

作者： Justin P.Miller-Schulze Michael Paulsen Takayuki Kameda Akira Toriba Kazuichi Hayakawa Brandon Cassidy Luke Naeher Manuel Aguilar Villalobos Christopher D.Simpson Department of Chemistry University of Washington WA 98195-1700 USA. Department of Environmental and Occupational Health Sciences University of Washington WA 98195 Seattle USA Laboratory of Hygienic Chemistry Instkute of Medical Pharmaceutical and Health Sciences Faculty of Pharmacy Kanazawa UniversityKakurna-machi Kanazawa Ishikawa 920-1192 Japan Graduate School of Natural Science and Technology Kanazawa University Kakma-machi Kanazawa Ishikawa 920-1192 Japan Department of Enuironmental Health Sciences University of Georgia Athens CA 30602-2102 USA Asociacion del Aire Ambiental Lima Peru

The assessment of occupational exposure to diesel exhaust（DE） is important from an epidemiological perspective. urinary biomarkers of exposure have been proposed as a novel approach for measuring exposure to DE. In this study, we measured the concentrations of two urinary metabolites of 1-nitropyrene（1NP）, a nitrated polycyclic aromatic hydrocarbon that has been suggested as a molecular marker of diesel particulate matter. These two metabolites, 6-hydroxy-1-nitropyrene and 8-hydroxy-1-nitropyrene, were determined in urine samples（10 m L） from a small group of workers who were occupationally-exposed to vehicle exhaust in Trujillo, Peru, before and after their workshifts. Workshift exposures to1 NP, as well as PM_（2.5）, 2-nitropyrene and 2-nitrofluoranthene, were also *** to 1NP were similar in all studied workers, averaging 105 ± 57.9 pg/m^3（±standard deviation）. Median urinary concentrations of the average of the pre- and post-exposure samples for 6-hydroxy-1-nitropyrene and 8-hydroxy-1-nitropyrene, were found to be 3.9 and 2.3 pg metabolite/mg creatinine, respectively in the group of occupationally-exposed subjects（n = 17） studied. A direct relationship between workshift exposure to 1NP and urinary 1NP metabolites concentrations was not observed. However,the 1NP exposures and the creatinine-corrected urinary concentrations of the hydroxynitropyrene metabolites in these Peruvian traffic workers were similar to occupationally-exposed taxi drivers in Shenyang, China, and were higher than biomarker levels in office workers from Trujillo without occupational exposure to vehicle *** study provides further evidence that urinary metabolites of 1NP are associated with exposure to DE and may serve as a useful exposure biomarker.

关键词： urinary biomarkers 1-nitropyrene diesel particulate matter

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