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Detection and Identification of Gonococci Resistance to Cephalosporin and Determination the Most Effective Empirical Treatment for Gonococcal urethritis in Male Human in Egypt

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Open Journal of Medical Microbiology 2022年第4期12卷 204-221页

作者： Somaih H. Mohammed Mohmed E. A. Dawoud Mohsen H. Attia Privet Microbiologist at Al-Kenana Laboratories Cairo Egypt Botany Department Faculty of Science Cairo University Cairo Egypt National Institute of Urology and Nephrology Cairo University Cairo Egypt

Introduction: Gonorrhoeae and antimicrobial resistance AMR of gonococci is a major health problem today, because emerged resistance to last line empirical treatment for gonorrhoeae cephalosporins in many countries is predictable to be untreatable disease in near future. WHO GASP, WHO GLASS and WHO’s global action plan on AMR recommends to expand nationally and internationally to collect data to monitor AMR of gonococci for public health policies. Objective: Our aim is to detect resistance of gonococci to Cepha- losporins and determine the most effective empirical treatment for un-com- plicated gonococcal urethritis in males in Egypt. Methods: We depended in our methodology on selected gonococci from male urethral discharge specimens on Thyer Martien medium;collected 33 isolates during three years from 2017 to 2020;used antibiotics with MIC according to international standards and measuring IZD according to antimicrobial susceptibility testing reference ranges in international standards. Results: By statistical studies, resistance to cephalosporins was as follows: Cephradine 97%, Cefaclor 87.9%, Cefoxitin 97%, Ceftriaxone 90.9% and 42.4% to Cefepime, that shows hetero-genecity in resistance inside cephalosporin group;while resistance to Macrolides group represented by Azithromycin and Tetracyclins group represented by Doxycycline was as follows: Azithromycin 39.4%, Doxycycilne 27.3%;finally fluoroquinolones, the most effective group, resistance, was as: Levofloxacin 15.2%, Ciprofloxacin 15.2% and Ofloxacin 24.2%. Conclusion: The most effective empirical treatment for uncomplicated gonococcal urethritis in males in EGYPT is Fluoroquinolone;especially Levofloxacin ranks first susceptibility as 78.8% and 15.2% resistance followed by Ciprofloxacin susceptibility as 69.7% and 15.2% resistance, finally Ofloxacin susceptibility as 66.7% and 24.2% resistance;for Ceftriaxone not more recommended in EGYPT as empirical treatment for uncomplicated gonococcal urethritis, it is su

关键词： Gonorrhoea urethritis Gonococcal urethritis Sexually Transmitted Diseases Resistance to Antibiotics in Human Gonococcal urethritis in Male in Egypt Resistance to Cephalosporins Resistance to Ceftriaxone Empirical Treatment for Gonococcal Urethriti Niesseria gonorrhoeae

Gonococcal urethritis accompanied by foreskin abscess:a case report

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International Journal of Dermatology and Venereology 2018年第4期1卷 243-245页

作者： Xiao-Min Zhang Hong-Quan Pi De-Hua Li Wen-Jun Zeng Department of Dermatology and STD Changping Hospital Dongguan Guangdong 523560 China Laboratory Medicine Changping Hospital Dongguan Guangdong 523560 China

Introduction urethritis, a common presentation of several sexually transmitted infections, results from infectious and noninfectious conditions. urethritis accounts for a significant burden of disease in young individuals over 2.8 million cases in the United States each year[1], and is associated with complications including acute epididymitis, orchitic, and prostatitis. Symptoms of urethritis include discharge of mucopurulent or purulent material, dysuria, or urethral frequency, pruritus. The most common infectious etiologies of urethritis are gonorrhea and chlamydia[2].

关键词： Gonococcal urethritis a significant burden of disease

103 CASES OF POSTPARTUM UROSCHESIS TREATED BY ACUPUNCTURE AT HUIYANG POINT

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Journal of Traditional Chinese Medicine 1996年第3期16卷 198-200页

作者：李玲周继芳施希鹏 Workers Hospital Taiyuan Chemical Fertilizer Plant Shanxi Province 030021 Shanxi College of Traditional Chinese Medicine Shanxi Province 030024

Retention of urine after parturition isfrequently encountered in *** methods of treatment can beadopted with certain *** these,urethral catheterization is often ***-ever,most patients are unwilling to receivethis manoeuvre because it may induce sub-sequent urethritis and urocystitis,and re-peated catheterization is required to bringforth any *** authors,nevertheless,

关键词： urethral urethritis sequent urine sensation needle acupuncture Acupuncture unable avail

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China Medical Abstracts(Internal Medicine) 1994年第1期11卷 1-4页