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Mechanism of therapeutic effects of Huangbo on ureteral stones based on network pharmacology

Journal of Hainan Medical University 2020年第22期26卷 47-52页

作者： Wen-Xiao Yu Ning Sun Fang Yuan Xiao-Hua Pei Beijing First Hospital of Integrated Traditional Chinese and Western Medicine Department of UrologyBeijing 100026 Beijing First Hospital of Integrated Traditional Chinese and Western Medicine Beijing 100026 Beijing Hospital of Traditional Chinese Medicine Capital Medical UniversityBeijing 100026China Beijing University of Chinese Medicine Hospital of Fangshan

Objective:To analyze the effective chemical components and action targets of Phellodendron chinense,and to study the mechanism of Phellodendron chinense in treating ureteral ***:Search the potential chemical active substances of Phellodendron chinense and target proteins acting on the human body through the TCMSP database,and use the genomic annotation database platform(Genecards)to predict the target of ureteral stones,and use the uniprot database Query the corresponding gene names,build a network diagram of"drug-disease-target"with the help of Cytoscape(3.7.2)software,build a protein interaction network through the String database platform,and then use the Bioconductor platform and R language GO Enrichment analysis and KEGG enrichment ***:Through screening,a total of 36 effective chemical constituents of Phellodendron chinense,8 key chemical constituents related to ureteral calculi,and 20 common targets of Phellodendron-ureteral calculi were *** core genes of PPI were FOS,CXCL8,IL6,SERPINE1,VEGFA,EGF,NOS3,SPP1,CCL2,CCND1,EGFR,HMOX1,IL10,CDKN1A,CRP;obtained 36 GO biological processes,and 14 KEGG related signaling pathways,including HIF-1 signaling pathway,FoxO signaling pathway,EGFR tyrosine kinase inhibitor resistance,endocrine resistance,viral protein interaction with cytokines and cytokine receptors,calcium signaling pathway,p53 signaling pathway,ErbB signaling pathway,MAPK signaling pathway,Ras signaling ***:Phellodendron can achieve the effect of treating ureteral calculi through multiple targets and multiple ways,which provides a theoretical basis for the future extraction of effective components to treat ureteral calculi.

关键词： Network pharmacology Huangbo ureteral stones Mechanism

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The effect of perirenal fat stranding on infectious complications after ureterorenoscopy in patients with ureteral calculi

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Asian Journal of Urology 2022年第3期9卷 307-312页

作者： Erhan Demirelli Ercan Ogreden Cemil Bayraktar Alptekin Tosun Ural Oguz Giresun University Faculty of MedicineDepartment of UrologyGiresunTurkey Ministry of Health Kayseri City HospitalDepartment of UrologyKayseriTurkey Giresun University Faculty of MedicineDepartment of RadiologyGiresunTurkey

Objective:Perirenal fat stranding(PFS)is linear areas of soft-tissue attenuation in the perirenal space on non-contrast computed *** present study aimed to investigate whether PFS is associated with infectious complications after ureterorenoscopy(URS)in patients with ureteral calculi in any ***:The data of 602 patients with ureteral stones who underwent URS were analyzed *** patients were divided into two groups as Group 1(PFS not detected)and Group 2(PFS detected).Gender,and age of patients,size,side,and location of the stone,operation time,double-J stent insertion status,perioperative ureter injury,postoperative infection after URS and related complications,and duration of hospital stay were ***:While PFS was not detected in 530 patients,PFS was detected in 72 *** mean age,male/female ratio,side and localization of the stones,operation time,and perioperative insertion of the double-J after lithotripsy were statistically similar(p>0.05).The median stone diameter was smaller in Group 2(9 mm vs.8 mm)(p=0.033).Fever was observed in 30 and 38 patients in Group 1 and Group 2,respectively(p=0.0001).Urinary tract infection was detected in 24 and 27 patients in Group 1 and Group 2,respectively(p=0.0001).The urosepsis did not occur in any patients in Group 1,whereas 8(11.1%)patients in Group 2 experienced urosepsis(p=0.0001).Conclusion:According to the results of the present study,patients with ureteral stones accompanied by PFS are much more prone to ureteral injuries and infectious complications such as urinary tract infection,fever,and sepsis after URS.

关键词： Perirenal fat stranding Infective complications Ureterorenoscopy ureteral stones Double-J stent

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Analysis on clinical distribution and drug resistance of pathogenic bacteria in the of 1368 cases mid-stream urine

Analysis on clinical distribution and drug resistance of pat...

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2014浙江省医学会男科学泌尿外科学学术年会

作者： Xiang HONG Qing kang XU Yue DUAN Wei hua SHEN Tain qing YU Xian jun SUN Department of Urology Zhejiang Provincal Crops Hospital of Chinese People’s Armed Police Force

Objective to analyze the pathogens and antibiltic resistance of urine cultu-re in patients with ureteral stones for the guidance of clinical medicine treatment and prevention and rational use of *** 1368 patients of ureteral stones treated clean urine culture and sensitivity from January of 2011-June of 2013 in our *** 238 pathogens were isolated from 1368 urine *** positive cocci accounted for 30.25%(72 cases),The majority was Enterococcus fasium and Staphylococcus aureus;In which Gram negative bacilli accounted for 66.81%(159 cases),the majority was the Escherichia coli(***)and Pseudomonas aeruginosa;Fungi accounted for 2.94%(7cases).There are a large difference in resistance to different bacterials,the performance is the different degrees of *** This study showed that with positive rate of 17.4%of the *** majority was Enterococcus fasium and the Escherichia coli(***).It is necessary for patients with ureteral calculi gived urine culture before *** are lagare significance to reduce the generation of broad-spectrum antibiotics and a reasonable choice of antibiotics.

关键词： ureteral stones urine culture pathogens drug resistance

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