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Non-transmissible Sendai virus vector encoding c-myc suppressor FBP-interacting repressor for cancer therapy

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World Journal of Gastroenterology 2014年第15期20卷 4316-4328页

作者： Kazuyuki Matsushita Hideaki Shimada Yasuji Ueda Makoto Inoue Mamoru Hasegawa Takeshi Tomonaga Hisahiro Matsubara Fumio Nomura Department of Molecular Diagnosis Graduate School of MedicineChiba UniversityChiba 260-8670Japan Department of Surgery School of MedicineToho UniversityTokyo 143-8541Japan DNAVEC Corporation 6 OhkuboTsukuba CityIbaraki 300-2611Japan Proteome Research Center Proteome Research ProjectNational Institute of Biomedical InnovationOsaka 567-0085Japan Department of Frontier Surgery Chiba UniversityGraduate School of MedicineChiba 260-8670Japan

AIM:To investigate a novel therapeutic strategy to target and suppress c-myc in human cancers using far up stream element(FUSE)-binding protein-interacting repressor(FIR).METHODS:Endogenous c-Myc suppression and apoptosis induction by a transient FIR-expressing vector was examined in vivo via a HA-tagged FIR(HA-FIR)expression vector.A fusion gene-deficient,non-transmissible,Sendai virus(SeV)vector encoding FIR cDNA,SeV/dF/FIR,was prepared.SeV/dF/FIR was examined for its gene transduction efficiency,viral dose dependency of antitumor effect and apoptosis induction in HeLa(cervical squamous cell carcinoma)cells and SW480(colon adenocarcinoma)cells.Antitumor efficacy in a mouse xenograft model was also examined.The molecular mechanism of the anti-tumor effect and c-Myc suppression by SeV/dF/FIR was examined using Spliceostatin A(SSA),a SAP155 inhibitor,or SAP155siRNA which induce c-Myc by increasing FIR△exon2 in HeLa cells.RESULTS:FIR was found to repress c-myc transcription and in turn the overexpression of FIR drove apoptosis through c-myc suppression.Thus,FIR expressing vectors are potentially applicable for cancer therapy.FIR is alternatively spliced by SAP155 in cancer cells lacking the transcriptional repression domain within exon 2(FIR△exon2),counteracting FIR for c-Myc protein expression.Furthermore,FIR forms a complex with SAP155 and inhibits mutual well-established functions.Thus,both the valuable effects and side effects of exogenous FIR stimuli should be tested for future clinical application.SeV/dF/FIR,a cytoplasmic RNA virus,was successfully prepared and showed highly efficient gene transduction in in vivo experiments.Furthermore,in nude mouse tumor xenograft models,SeV/dF/FIR displayed high antitumor efficiency against human cancer cells.SeV/dF/FIR suppressed SSA-activated c-Myc.SAP155 siRNA,potentially produces FIR△exon2,and led to c-Myc overexpression with phosphorylation at Ser62.HA-FIR suppressed endogenous c-Myc expression and induced apoptosis in HeLa and SW480 cells.A c-myc transcriptional supp

关键词： Cancer gene therapy c-myc suppressor Far up stream

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优品 2013年第1期 298-306页

Corneliani将于上海设旗舰店全球高端时尚男装的领导者、意大利品牌Corneliani将位于上海的独立旗舰店开幕作为2012年底的重头戏。此店由Poddapontiarchitetti建筑设计事务所设计,深入人心的设计理念淋漓尽致地表达了新一代品牌精品店... 详细信息

Corneliani将于上海设旗舰店全球高端时尚男装的领导者、意大利品牌Corneliani将位于上海的独立旗舰店开幕作为2012年底的重头戏。此店由Poddapontiarchitetti建筑设计事务所设计,深入人心的设计理念淋漓尽致地表达了新一代品牌精品店的概念。店面的精致风格是以米兰旗舰店昕使用的材料和色调为基础,再现的过程中又进行了新的润色处理。一进入大门就会立刻被Corneliani的世界所吸引,依次陈列的有皮革制品、配饰以及深受顾客喜爱的Corneliani ID休闲系列优雅服饰。

关键词：百年灵奢侈品市场智能操作系统设计机构 up REPORT 卡萨三星电子芳草地舒尔中国电

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优品 2013年第6期 271-277页

***2013新品预览4月9日,FASHIONandcom于北京东站画廊宣布正式上线,并举办了2013春夏新品预览会。FASHIONand全新春夏广告片的女主角国际超模秦舒培也亲临现场,和全国媒体共同见证FASHIONand带来的这场时尚饕餮。FASHIONand为中国潮流... 详细信息

***2013新品预览4月9日,FASHIONandcom于北京东站画廊宣布正式上线,并举办了2013春夏新品预览会。FASHIONand全新春夏广告片的女主角国际超模秦舒培也亲临现场,和全国媒体共同见证FASHIONand带来的这场时尚饕餮。FASHIONand为中国潮流女性甄选最具质感且独特的时尚前沿品牌。

关键词：高尔夫球协会时尚前沿品牌体验 up REPORT 沃尔沃汽车珠宝品牌上海车展宝马集团飞机

A STUDY ON THE DYNAMIC RESPONSE OF CAM BEAT-up MOTIONS FOR RAPIER LOOMS

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Journal of China Textile University(English Edition) 1996年第2期13卷 48-55页

作者：施雷飚陈明

Based on the requirements of the two-phase rapier loom’s beat-up system characteristics, the dynamic responses of its beat-up system to three different types of cam input motion are studied in this paper. Also, their corresponding analytical comparisons are made. At the end of the paper, the authors put forward a proposal of new type cam beat-up motion for future practice.

关键词： beat up motion dynamic response rapier loom simple harmonic double harmonic cycloidal triple harmonic

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优品 2012年第11期 274-283页

JMWeston 2012皮具系列发布J.M.Weston从鞋履产品的结构美学中汲取灵感,推出品牌首个大件皮具系列Grand Angle,重新演绎"角与线"精巧的完美融合。此次,制鞋大师拓宽了自身视角,并秉承品牌的经典传承:热爱皮革、线条的魅力以及细节创造... 详细信息

JMWeston 2012皮具系列发布J.M.Weston从鞋履产品的结构美学中汲取灵感,推出品牌首个大件皮具系列Grand Angle,重新演绎"角与线"精巧的完美融合。此次,制鞋大师拓宽了自身视角,并秉承品牌的经典传承:热爱皮革、线条的魅力以及细节创造精致。系列中所有皮具以及包袋的手工艺制作全出自J.M.Weston工作室里的制鞋专家们。手工裁剪取代机器滚边,传统缝制工艺的细节以及高雅精致的面料,无不传承了品牌悠久历史沉淀下来的精髓。在坚持一贯的舒适性能的同时,Grand.Angle系列的每一款包袋在设计上更加注重实用性,适合全天候各种场合的搭配。

关键词：大众汽车集团 up REPORT 竹叶青茶彩妆雷克萨斯国际家具展格兰杰概念店辅助医学达

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优品 2012年第6期 24-32,34,36,38页

La Perla进驻北京新光天地4月25日,来自意大利的内衣奢侈品牌La Perla将欧洲顶级内衣带进了国际高端百货新光天地。北京新光天地的副总经理甘添信先生、庞琨瑢女士、La Perla执行董事AndreaBonardi与意大利经济参赞Livio Spadavecchia,... 详细信息

La Perla进驻北京新光天地4月25日,来自意大利的内衣奢侈品牌La Perla将欧洲顶级内衣带进了国际高端百货新光天地。北京新光天地的副总经理甘添信先生、庞琨瑢女士、La Perla执行董事AndreaBonardi与意大利经济参赞Livio Spadavecchia,一同出席了当天的活动,并与来宾们一起穿越了由La Perla精心打造的时光隧道。

关键词：新光天地奢侈品牌雅宝 up REPORT 卡萨宾利美诺台式电脑华硕电脑家电品牌

Transanal total mesorectal excision:a valid option for rectal cancer?

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World Journal of Gastroenterology 2015年第41期21卷 11700-11708页

作者： Nicolas C Buchs Gary A Nicholson Frederic Ris Neil J Mortensen Roel Hompes Department of Colorectal Surgery Churchill Hospital Oxford University Hospitals Division of Visceral Surgery Department of Surgery University Hospitals of Geneva Nuffield Department of Surgical Science University of Oxford John Radcliffe Hospital

Low anterior resection can be a challenging operation, especially in obese male patients and in particular after radiotherapy. Transanal total mesorectal excision(Ta TME) might offer technical advantages over laparoscopic or open approaches particularly for tumors in the distal third of the rectum. The aim of this article is to review the current experience with Ta TME. The limits and future developments are also explored. Although the experience with Ta TME is still limited, it might be a promising alternative to laparoscopic TME, especially for difficult cases where laparoscopy is too demanding. The preliminary data on complications and short-term oncological outcomes are good, but also emphasize the importance of careful patient selection. Finally, there is a need for large-scale trials focusing on long-term outcomes and oncological safety before widespread adoption can be recommended.

关键词： Transanal Bottom up Transanal minimally invasive s

Radiation risks associated with serial imaging in colorectal cancer patients:Should we worry?

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World Journal of Gastroenterology 2014年第1期20卷 100-109页

作者： Jeong Suk Oh Jonathan B Koea Department of Surgery North Shore HospitalAuckland 0620New Zealand

To provide an overview of the radiation related cancer risk associated with multiple computed tomographic scans required for follow up in colorectal cancer patients.A literature search of the PubMed and Cochrane Library databases was carried out and limited to the last 10 years from December 2012.Inclusion criteria were studies where computed tomographic scans or radiation from other medical imaging modalities were used and the risks associated with ionizing radiation reported.Thirty-six studies were included for appraisal with no randomized controlled trials.Thirty-four of the thirty-six studies showed a positive association between medical imaging radiation and increased risk of cancer.The radiation dose absorbed and cancer risk was greater in children and young adults than in older patients.Most studies included in the review used a linear,nothreshold model to calculate cancer risks and this may not be applicable at low radiation doses.Many studies are retrospective and ensuring complete follow up on thousands of patients is difficult.There was a minor increased risk of cancer from ionizing radiation in medical imaging studies.The radiation risks of low dose exposure(up will need to be revised to accommodate a more aggressive approach to treating metastatic disease.

关键词： Colorectal cancer Follow up Surveillance Radiology

Japan's Economy after the Catching-up Period and Sino-Japanese cooperation

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Contemporary International Relations 2003年第11期13卷 22-27页

作者： Zhang Shuying is a Research Professor and Director at the division for Japan Economy, Institute for Japanese Studies of China Academy of Social Sciences.

Japan’s GNP jumped to the second place in the world in 1968, surpassing that of West Germany. Its GNP per capita exceeded that of the U. S. in 1987. In terms of economic structure and technological e-quipments, Japan ranked among the most developed countries. Thus, Japan had completed the catching-up period and stepped into a new e-poch. The inflation and the burst of the bubble economy is another evi-

关键词： that been into of up GNP for than have