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Effect of universal salt iodization on antithyroid drugs

Chinese Medical Journal 2006年第13期119卷 1108-1112页

作者： DAI Wei-xin LIAN Xiao-lan LU Lin LI Su-mei LI Shu-hua LI Xiu-wei Department of Endocrinology Peking Union Medical College Hospital Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100730 China National Iodide-Deficiency Reference Laboratory of China Beijing102206 China

Iodine deficiency disease （IDD） is common in China. An universal salt iodization （USl） program has been implemented by the Chinese government since 1996. As a result, the goiter rate in 8- to 10-year old children decreased from 20.4% in 1995 to 5.8% in 2002.1 But the adverse effects of iodine excess such as iodine-induced hyperthyroidism, iodine-induced goiters, iodine-induced hypothyroidism, etc. have become a great concern to healthcare professionals as well as the general population. The impact of USI on antithyroid drugs （ATDs） might become a potential challenge to address. With a special grant from the Department of Disease Control, the Health Ministry of China, we conducted a prospective study on the effects of USI on ATDs at the thyroid section of the Endocrinology Clinic of Peking Union Medical College Hospital （PUMCH）, Beijing.

关键词： iodine deficiency disease universal salt iodization antithyroid drugs

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Relationship between Iodine Content in Household Iodized salt and Thyroid Volume Distribution in Children

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Biomedical and Environmental Sciences 2016年第6期29卷 391-397页

作者： CHAO Hong ZHANG Yu Fu LIU Peng HAN Yun Feng LIU Shou Jun Institute of Iodine Deficiency Disorders Center for Endemic Disease Control Chinese Center for Disease Control and Prevention Harbin Medical University Harbin 150081 Heilongiiang China Jiangsu Center for Disease Control and Prevention Nanjing 210009 Jiangsu China Qiqihar Medical University Qiqihar 161000 Heilongjiang China

Objective To assess the effect of different levels of salt iodine content on thyroid volume（ThV） distribution using data from the 1999, 2011, and 2014 Chinese national iodine deficiency disorder（IDD） surveys. Methods Probability proportion to size（PPS） sampling method was used to obtain a representative national sample of 34,547, 38,932, and 47,188 Chinese children aged 8-10 years in 1999, 2011, and 2014 Chinese national IDD surveys, respectively. The iodine content in household iodized salt and urinary iodine concentration were measured and thyroid ultrasound examination was performed. The data were analyzed by SAS software using histograms and box plots. The skewness and kurtosis were calculated for testing the normality of ThV. Results The median iodine content in household iodized salt dropped from 42.30 mg/kg in 1999 to 25.00 mg/kg in 2014. The median urinary iodine concentration of children aged 8-10 years decreased from 306.0 μg/L in 1999 to 197.9 μg/L in 2014. The median and interquartile range（IQR） of ThV in 1999, 2011, and 2014 surveys were 3.44 m L and 1.50 m L, 2.60 m L and 1.37 m L, 2.63 m L and 1.25 m L, respectively. The skewness and kurtosis of ThV distribution in 1999, 2011, and 2014 surveys were 1.34 and 5.84, 0.98 and 3.54, 1.27 and 5.49, respectively. Conclusion With reduced salt iodization levels, the median urinary iodine concentration and median ThV of children decreased significantly, and the symmetry of the ThV distribution improved.

关键词： Thyroid volume Iodized salt Children Iodine deficiency disorders universal salt iodization

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Iodine Content of Processed Foods and Condiments Sampled in China, 2017-2019

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Food and Nutrition Sciences 2021年第12期12卷 1217-1231页

作者： Zhu Wang Jun Wang Weisheng Xu Jing Xu Xiuwei Li Jia Zhao Guodong Wang Xiaoguang Yang National Institute for Nutrition and Health Chinese Center for Disease Control and Prevention Beijing China Key Laboratory of Trace Element Nutrition National Health Commission Beijing China Central Laboratory of Shenzhen Center for Chronic Disease Control Shenzhen China National Reference Laboratory for Iodine Deficiency Disorders Beijing China

Introduction: Facing the challenge of increasing consumption of processed foods in China, along with the demand for salt reduction, and dynamic adjustment of universal salt iodization (USI) policy, it is necessary to timely evaluate the distribution of iodine content in processed foods and condiments, so as to provide more accurate data for population dietary iodine intake assessment. Methods: From markets in 6 cities and e-commerce platforms, cereal, tuber, legume, meat, fish, egg, and dairy products, and condiments, consumed by volunteers who attended in iodine intake investigation, and top selling products in particular with well-noted brands were preferentially sampled during 2017 to 2019. After being mixed and homogenized, each sample was detected by ICP-MS method. The range and medium of iodine content in each type of product were given. Results: After merging samples with close value in the same style of the same brand, and screening out samples with no added salt or low sodium content (≤120 mg/100g), total 725 data were sub-grouped and analyzed. In comparison with the 95th percentile of the iodine distribution in relative nature source, assessed by our previous study, nearly 77% of products made from grains, potatoes, beans, nuts, livestock and poultry meat were presumed to be processed with iodized salt. In somewhat, related with sodium value marked on food labeling, the median iodine ranged from 1.1 mg/100g to 149 mg/100g. The variation of iodine in egg, milk and fish made products, and seaweed or with seaweed products was greatly affected by the background of ingredients, the median content most floated between 12.8 mg/100g and 86.8 mg/100g, even up to 1800 mg/100g in seasoned seaweed. Based on the frequency of iodine digital and the ratio of iodine to sodium, it was speculated th

关键词： Iodine Content universal salt iodization Processed Food Edible salt Database

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