检索结果-南通市图书馆

Impact of utilization of hepatitis C positive organs in liver transplant:Analysis of united network for organ sharing database

引用

World Journal of Hepatology 2022年第5期14卷 984-991页

作者： Amaninder Dhaliwal Banreet Dhindsa Daryl Ramai Harlan Sayles Saurabh Chandan Rajani Rangray Department of Gastroenterology and Hepatology Moffitt Cancer CenterTampaFL 33612United States Department of Gastroenterology and Hepatology University of Nebraska Medical CenterOmahaNE 68198United States Department of Internal Medicine The Brooklyn Hospital CenterBrooklynNY 11201United States Department of Biostatistics University of Nebraska Medical CenterOmahaNE 68198United States Department of Gastroenterology and Hepatology Creighton University Medical CenterOmahaNE 68124United States

BACKGROUND The utility of hepatitis C virus(HCV)organs has increased after the Food and Drug Administration approval of direct acting anti-viral(DAA)medications for the HCV *** efficacy of DAA in treating HCV is nearly 100%.AIM To analyze the united network for organ sharing(UNOS)database to compare the survival rates between the hepatitis C positive donors and negative recipients and hepatitis C negative donors and *** We analyzed the adult patients in UNOS database who underwent deceased donor liver transplant from January 2014 to December *** primary endpoint was to compare the survival rates among the four groups with different hepatitis C donor and recipient status:(Group 1)Both donor and recipient negative for HCV(Group 2)Negative donor and positive recipient for HCV(Group 3)Positive donor and negative recipient for HCV(Group 4)Both positive donor and recipient for *** 9.4 software was used for the data *** Meier log rank test was used to analyze the estimated survival rates among the four *** A total of 24512 patients were included:Group 1:16436,Group 2:6174,Group 3:253 and Group 4:*** 1-year(Group 1:91.8%,Group 2:92.12%,Group 3:87%,Group 4:92.8%),2-year(Group 1:88.4%,Group 2:88.1%,Group 3:84.3%,Group 4:87.5%),3-year(Group 1:84.9%,Group 2:84.3%,Group 3:75.9%,Group 4:83.2%)survival rates showed no statistical significance among the four *** Meier log rank test did not show any statistical significance difference in the estimated survival rates between Group 3 vs all the other *** The survival rates in hepatitis C positive donors and negative recipients are similar as compared to both hepatitis C negative donors and *** could be due to the use of DAA therapy with cure rates of nearly 100%.This study supports the use of hepatitis C positive organs in the selected group of recipients with and without HCV *** long-term studies are needed to further valid

关键词： Hepatitis C Liver transplant Survival united network for organ sharing Direct acting antiviral

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Analysis of hepatitis C virus-positive organs in liver transplantation

引用

World Journal of Hepatology 2022年第9期14卷 1840-1843页

作者： Isabel Legaz Manuel Muro Department of Legal and Forensic Medicine Biomedical Research InstituteRegional Campus of International Excellence"Campus Mare Nostrum"Faculty of MedicineUniversity of MurciaMurcia 30100Spain Department of Immunology Service Instituto Murciano de Investigación BiosanitariaHospital Clínico Universitario Virgen de la ArrixacaMurcia 30120Spain

The authors of this study note that in liver transplantation(LT),the survival rates of hepatitis C virus(HCV)-positive donors and HCV-negative receivers are compa-rable to those of HCV-negative donors and ***-acting antiviral(DAA)therapies have nearly 100%effectiveness in treating *** 2006 and 2016,the percentages of HCV-positive patients on the waiting list and HCVpositive LT recipients fell by 8.2 percent and 7.6 percent,*** from April 1,2014,in which the donor and receiver were both at least 18 years old and had a positive HCV status,were the only ones eligible for the *** analysis for this study was restricted to the first transplant recorded for each patient using a data element that documented the number of prior transplants for each recipient,although some recipients appeared multiple times in the data ***-positive recipients or people with fulminant hepatic failure were the main beneficiaries of primary biliary cirrhosis among HCV-positive ***,there is still a reticence to use HCV-positive donor organs in HCV recipients due to clinical and ethical *** survival rates between HCV-positive donors and recipients and HCV-negative donors and receivers illustrate the efficacy of these DAA regimens.

关键词： Hepatitis C virus Liver transplant Graft survival united network for organ sharing Direct-acting antiviral

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：