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underlying mechanisms and clinical potential of circRNAs in glioblastoma

Oncology Research 2023年第4期31卷 449-462页

作者： LEI ZHANG YUAN ZHANG HUIJUAN GAO XIN LI PEIFENG LI Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityQingdao UniversityQingdao266021China

Glioblastoma(GBM)is the most malignant form of glioma and is difficult to diagnose,leading to high mortality *** RNAs(circRNAs)are noncoding RNAs with a covalently closed loop *** are involved in various pathological processes and have been revealed to be important regulators of GBM *** exert their biological effects by 4 different mechanisms:serving as sponges of microRNAs(miRNAs),serving as sponges of RNA binding proteins(RBPs),modulating parental gene transcription,and encoding functional *** the 4 mechanisms,sponging miRNAs is *** good stability,broad distribution and high specificity make circRNAs promising biomarkers for GBM *** this paper,we summarized the current understanding of the characteristics and action mechanisms of circRNAs,illustrated the underlying regulatory mechanisms of circRNAs in GBM progression and explored the possible diagnostic role of circRNAs in GBM.

关键词： CircRNAs GBM underlying mechanisms Clinical value

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Additive manufacturing of magnesium and its alloys: process-formabilitymicrostructure-performance relationship and underlying mechanism

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International Journal of Extreme Manufacturing 2023年第4期5卷 247-290页

作者： Shang Sui Shuai Guo Dong Ma Can Guo Xiangquan Wu Zhongming Zhang Chunjie Xu Dan Shechtman Sergei Remennik Daniel Safranchik Rimma Lapovok School of Materials Science and Engineering Xi’an University of TechnologyXi’anShaanxi 710048People’s Republic of China Xi’an Shechtman Nobel Prize New Materials Institute Xi’an 710048People’s Republic of China Xi’an Key Laboratory of Advanced Magnesium Alloy Additive Manufacturing and Precision Forming Xi’anShaanxi 710048People’s Republic of China School of Materials Science and Engineering Liaocheng UniversityLiaochengShandong 252059People’s Republic of China Department of Materials Science and Engineering Technion-Israel Institute of TechnologyHaifa 32000Israel Center for Nanoscience&Nanotechnology Hebrew University of JerusalemEdmond J.Safra CampusJerusalem 91904Israel Israel Institute of Metals Technion CityHaifa 3200003Israel Institute for Machine Elements Engineering Design and ManufacturingFreiberg 09599Germany Geelong Waurn Ponds Campus Deakin UniversityPigdons RoadGeelongVic 3216Australia

Magnesium and its alloys,as a promising class of materials,is popular in lightweight application and biomedical implants due to their low density and good *** manufacturing(AM)of Mg and its alloys is of growing interest in academia and *** domain-by-domain localized forming characteristics of AM leads to unique microstructures and performances of AM-process Mg and its alloys,which are different from those of traditionally manufactured ***,the intrinsic mechanisms still remain unclear and need to be in-depth ***,this work aims to discuss and analyze the possible underlying mechanisms regarding defect appearance and elimination,microstructure formation and evolution,and performance improvement,based on presenting a comprehensive and systematic review on the relationship between process parameters,forming quality,microstructure characteristics and resultant ***,some key perspectives requiring focus for further progression are highlighted to promote development of AM-processed Mg and its alloys and accelerate their industrialization.

关键词： additive manufacturing magnesium alloys underlying mechanisms forming quality microstructure characteristics and properties

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Identification of ANXA1 as a potential prognostic biomarker and correlating with immune infiltrates in colorectal cancer

Identification of ANXA1 as a potential prognostic biomarker ...

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2022第27届广东省药师周大会

作者： Zhikun Liang Xiaoyan Li Department of Pharmacy the Sixth Affiliated HospitalSun Yat-Sen University

Background:ANXA1 is a calcium-dependent phospholipid-binding protein and is frequently associated with inflammation,cell proliferation and ***,the relationship between ANXA1 and the prognosis of multiple tumors and tumor infiltrating immune cells remains ***:Multivariate Cox proportional regression analysis was used for signature genes exploration in the basic of colon adenocarcinoma(COAD) RNA-sequence dataset obtained from TCGA,following the identification of 267 common differentially expressed genes,including ANXA1,among three expression profile datasets(GSE41328,GSE110224 and GSE113513).The differential expression of ANXA1 in different tumors and their corresponding normal tissues were evaluated through the Tumor Immune Estimation Resource(TIMER) and Oncomine ***,we investigated the correlation between the expression level of ANXA1 and diverse panel ofinfiltratingimmune cells and their related gene markers in colorectal cancer using correlation analysis in TIMER and GEPIA ***:ThehighexpressionofANXA1 was demonstrated to be closelycorrelatedwithpoorsurvivalinpatients with *** importantly,we found that changes in ANXA1 expression showed a moderate to strong,and statistically significant,correlation with infiltrating levels of B cells,CD8+ T cells,CD4+ T cells,macrophages,neutrophils and dendritic *** contrast,there are only weak correlations between ANXA1 expression and immune cell infiltration in ESCA and ***1 expression was considerably associated with variousimmune markers involving immune cell recruitment,polarization of tumor-associated macrophages,and T cell ***:ANXA1 is not only an independent risk factor in the prediction of theprognosis of colorectal cancer,but also a crucial regulator in immune cell *** study may shed light on the clinical value of ANXA1,especially in the areas of early diagnosisof colorectal cancer and therapeutic target

关键词： Colorectal cancer Differently expressed genes underlying mechanisms Prediction model Immune infiltrates

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