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Effects of COVID-19 on the liver:The experience of a single center

World Journal of Gastroenterology 2022年第39期28卷 5735-5749页

作者： Valentina Liakina Ieva Stundiene Gabriele Milaknyte Ramune Bytautiene Rosita Reivytyte Roma Puronaite Gintare Urbanoviciute Edita Kazenaite Centre of Hepatology Gastroenterology and DieteticsClinic of GastroenterologyNephrourology and SurgeryInstitute of Clinical MedicineFaculty of MedicineVilnius UniversityVilnius 01513Lithuania Department of Chemistry and Bioengineering Faculty of Fundamental SciencesVILNIUS TECHVilnius 10223Lithuania Faculty of Medicine Vilnius UniversityVilnius 01513Lithuania Clinic of Cardiac and Vascular diseases Institute of Clinical MedicineFaculty of MedicineVilnius UniversityVilnius 01513Lithuania Institute of Data Science and Digital Technologies Faculty of Mathematics and InformaticsVilnius UniversityVilnius 01513Lithuania Department of Pathology Forensic Medicine and PharmacologyInstitute of Biomedical SciencesFaculty of MedicineVilnius UniversityVilnius 01513Lithuania

BACKGROUND The coronavirus disease 2019(COVID-19)was perhaps the most severe global health crisis in living *** respiratory symptoms,elevated liver enzymes,abnormal liver function,and even acute liver failure were reported in patients suffering from severe acute respiratory disease coronavirus 2 ***,the precise triggers of these forms of liver damage and how they affect the course and outcomes of COVID-19 itself remain *** To analyze the impact of liver enzyme abnormalities on the severity and outcomes of COVID-19 in hospitalized *** In this study,684 depersonalized medical records from patients hospitalized with COVID-19 during the 2020-2021 period were ***-19 was diagnosed according to the guidelines of the National Institutes of Health(2021).Patients were assigned to two groups:those with elevated liver enzymes(Group 1:603 patients),where at least one out of four liver enzymes were elevated(following the norm of hospital laboratory tests:alanine aminotransferase(ALT)≥40,aspartate aminotransferase(AST)≥40,gamma-glutamyl transferase≥36,or alkaline phosphatase≥150)at any point of hospitalization,from admission to discharge;and the control group(Group 2:81 patients),with normal liver enzymes during ***-19 severity was assessed according to the interim World Health Organization guidance(2022).Data on viral pneumonia complications,laboratory tests,and underlying diseases were also collected and *** In total,603(88.2%)patients produced abnormal liver test *** and AST levels were elevated by a factor of less than 3 in 54.9%and 74.8%of cases with increased enzyme levels,*** in Group 1 had almost double the chance of bacterial viral pneumonia complications[odds ratio(OR)=1.73,P=0.0217],required oxygen supply more often,and displayed higher biochemical inflammation indices than those in Group *** differences in other COVID-19 complications or underlying disea

关键词： COVID-19 SARS-CoV-2 Liver enzymes Complications underlying disease disease severity

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