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Ginsenoside F1 administration promotes UCP1-dependent fat browning and ameliorates obesity-associated insulin resistance

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Food Science and Human Wellness 2023年第6期12卷 2061-2072页

作者： Yuhan Meng Weili Li Chenxing Hu Si Chen Haiyang Li Feifei Bai Lujuan Zheng Ye Yuan Yuying Fan Yifa Zhou Engineering Research Center of Glycoconjugates of Ministry of Education Jilin Provincial Key Laboratory of Chemistry and Biology of Changbai Mountain Natural DrugsSchool of Life SciencesNortheast Normal UniversityChangchun 130024China

Obesity-induced type 2 diabetes is mainly due to excessive free fatty acids leading to insulin *** thermogenesis is regarded as an effective strategy for hypolipidemia and *** is a natural active component in Panax ginseng ***,and some of them enhance ***,there are few studies on the mechanism and target of ginsenosides enhancing *** thermogenic protein uncoupling protein 1(UCP1)-luciferase reporter assay,we identifi ed ginsenoside F1 as a novel UCP1 activator in the ginsenosides *** pull down assay and inhibitor interference,we found F1 binds toβ3-adrenergic receptors(β3-AR)to enhance UCP1 expression via cAMP/PKA/CREB *** also investigated the ability of F1 on energy metabolism in obesity-induced diabetic mice,including body weight,body composition and energy *** results of proteomics showed that F1 signifi cantly up-regulated thermogenesis proteins and lipolytic proteins,but down-regulated fatty acid synthesis *** F1 increased thermogenesis and ameliorated insulin resistance specifi cally by promoting the browning of white adipose tissue in obese ***,ginsenoside F1 improves norepinephrine-induced insulin resistance in adipocytes and hepatocytes,and shows a stronger mitochondria respiration ability than *** fi ndings suggest that ginsenoside F1 is a promising lead compound in the improvement of insulin resistance.

关键词： Ginsenoside F1 uncoupling protein 1 β3-Adrenergic receptor White adipose tissue browning Insulin resistance

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Visualization of Activated BAT in Mice,with FDG-PET and Its Relation to UCP1

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Advances in Molecular Imaging 2013年第3期3卷 19-22页

作者： Christian Jeanguillaume Gilles Metrard Daniel Ricquier Pierre Legras Francis Bouchet Franck Lacoeuille Francois Hindre Olivier Morel Herve Rakotonirina Service de Medecine Nucleaire CHU d’AngersAngersFrance LISA ISTIA Universite d’AngersAngersFrance Service de Medecine Nucleaire CHR d’OrleansOrleansFrance Universite Paris Descartes Institut CochinParisFrance Service Commun d’Animalerie Hospitalo Universitaire(SCAHU)AngersFrance Unite Inserm U646 AngersFrance Service de Médecine Nucléaire ICOPaul PapinAngersFrance

The visualization of symmetric structure by [18F]-FluoroDeoxyGlucose-Positron Emission Tomography (FDG-PET), corresponding to adipose density in computed tomography (CT), has led to the idea that Brown Adipose Tissue (BAT) could be present in adult human. This article studies the FDG uptake in a mice model deficient on uncoupling protein 1 (UCP1), in a simple thermal activation protocol. Methods: FDG were injected in mice, control and knock out (K.O.) for the UCP1. Before imaging mice were placed either in cold or warm environment. BAT uptake was evaluated by ratio named RISC. Results: In warm condition, mean value of the Ratio of Inter-Scapular uptake (RISC) was 1.34 +/﹣ 0.27. After cold exposure, RISC increased 2 fold for control mice, male K.O. did not increase their RISC, female K.O. increased their RISC up to 2.45. Conclusion: Our study brought a further confirmation that FDG-PET visualised activated Brown Adipose Tissue. It gives a direct proof of the role of UCP1 in this process. The FDG uptake by cold female K.O. mice was unexpected.

关键词： FDG PET Brown Adipose Tissue uncoupling protein 1 Mice

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