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Molecular mechanism of SCARB2-mediatec attachment and uncoating of EV71

Protein & Cell 2014年第9期5卷 692-703页

作者： Minghao Dang Xiangxi Wang Quan Wang Yaxin Wang Jianping Lin Yuna Sun Xuemei Li Liguo Zhang Zhiyong Lou Junzhi Wang Zihe Rao National Laboratory of Macromolecules Institute of Biophysics Chinese Academy of Science Beijing 100101 China Laboratory of Structural Biology School of Medicine Tsinghua University Beijing 100084 China School of Life Sciences School of Pharmacy Nankai University Tianjin 300071 China National Institutes for Food and Drug Control Beijing 100050 China

Unlike the well-established picture for the entry of enveloped viruses, the mechanism of cellular entry of non-enveloped eukaryotic viruses remains largely mysterious. Picornaviruses are representative models for such viruses, and initiate this entry process by their functional receptors. Here we present the structural and functional studies of SCARB2, a functional receptor of the important human enterovirus 71 （EV71）. SCARB2 is responsible for attachment as well as uncoating of EV71. Differences in the structures of SCARB2 under neutral and acidic conditions reveal that SCARB2 undergoes a pivotal pH-dependent conformational change which opens a lipid-transfer tunnel to mediate the expulsion of a hydrophobic pocket factor from the virion, a pre-requisite for uncoating. We have also identified the key residues essential for attachment to SCARB2, identifying the canyon region of EV71 as mediating the receptor interaction. Together these results provide a clear understanding of cellular attachment and initiation of uncoating for enteroviruses.

关键词： viral entry uncoating picornavirusesreceptor binding SCARB2 EV71 lipid transfer tunnel

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Multiple Roles of HIV-1 Capsid during the Virus Replication Cycle

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Virologica Sinica 2019年第2期34卷 119-134页

作者： Mariia Novikova Yulan Zhang Eric O. Freed Ke Peng Virus-Cell Interaction Section HIV Dynamics and Replication Program Center for Cancer Research National Cancer Institute Frederick MD 21702 USA State Key Laboratory of Virology Wuhan Institute of Virology Chinese Academy of Sciences Wuhan 430071 China

Human immunodeficiency virus-1 capsid(HIV-1 CA) is involved in different stages of the viral replication cycle. During virion assembly, CA drives the formation of the hexameric lattice in immature viral particles, while in mature virions CA monomers assemble in cone-shaped cores surrounding the viral RNA genome and associated proteins. In addition to its functions in late stages of the viral replication cycle, CA plays key roles in a number of processes during early phases of HIV-1 infection including trafficking, uncoating, recognition by host cellular proteins and nuclear import of the viral preintegration complex. As a result of efficient cooperation of CA with other viral and cellular proteins, integration of the viral genetic material into the host genome, which is an essential step for productive viral infection, successfully occurs. In this review, we will summarize available data on CA functions in HIV-1 replication, describing in detail its roles in late and early phases of the viral replication cycle.

关键词： Human immunodeficiency virus-1 (HIV-1) Capsid (CA) Assembly Post entry uncoating and nuclear import Inhibitor

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