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Human umbilical cord-derived mesenchymal stem cells promote repair of neonatal brain injury caused by hypoxia/ischemia in rats

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Neural Regeneration Research 2022年第11期17卷 2518-2525页

作者： Yang Jiao Yue-Tong Sun Nai-Fei Chen Li-Na Zhou Xin Guan Jia-Yi Wang Wen-Juan Wei Chao Han Xiao-Lei Jiang Ya-Chen Wang Wei Zou Jing Liu stem Cell Clinical Research Center National Joint Engineering LaboratoryRegenerative Medicine CenterThe First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning ProvinceChina Dalian Innovation Institute of stem cells and Precision Medicine DalianLiaoning ProvinceChina Department of Neurology The First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning ProvinceChina College of Life Science Liaoning Normal UniversityDalianLiaoning ProvinceChina

Administration of human umbilical cord-derived mesenchymal stem cells(hUC-MSCs)is believed to be an effective method for treating neurodevelopmental disorde *** this study,we investigated the possibility of hUC-MSCs treatment of neonatal hypoxic/ischemic brain injury associated with maternal immune activation and the underlying *** established neonatal rat models of hypoxic/ischemic brain injury by exposing pregnant rats to lipopolysaccharide on day 16 or 17 of *** offspring were intranasally administe red hUC-MSCs on postnatal day *** found that polypyrimidine tract-binding protein-1(PTBP-1)participated in the regulation of lipopolysaccharide-induced maternal immune activation,which led to neonatal hypoxic/ischemic brain *** delive ry of hUC-MSCs inhibited PTBP-1 expression,alleviated neonatal brain injury-related inflammation,and regulated the number and function of glial fibrillary acidic protein-positive astrocytes,there by promoting plastic regeneration of neurons and im p roving brain *** findings suggest that hUC-MSCs can effectively promote the repair of neonatal hypoxic/ischemic brain injury related to maternal immune activation through inhibition of PTBP-1 expression and astrocyte activation.

关键词： developmental brain disease model disease-associated astrocytes intranasal administration lipopolysaccharide maternal immune activation neonatal brain injury neuroplasticity repair polypyrimidine tract-binding protein-1 stem cell therapy umbilical cord-derived mesenchymal stem cells

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umbilical cord-derived mesenchymal stem cells(UC-MSCs)suppress inflammatory responses via regulation of the Galectin-9/Tim-3 pathway in primary biliary cholangitis

Umbilical cord-derived mesenchymal stem cells(UC-MSCs)suppre...

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第十二届全国免疫学学术大会

作者： Fan junyu Wang Qian Wu Shufang Tang Xiaojun Sun Lingyun Department of Rheumatology and Immunology The Affiliated Drum Tower Hospital of Nanjing University Medical School

Background:Primary biliary cholangitis(PBC)is a cholestatic liver disease characterized by slowly progressive non-suppurative cholangitis with immune mediated destruction of intrahepatic bile *** studies have shown be... 详细信息

关键词： umbilical cord-derived mesenchymal stem cells primary biliary cholangitis Galectin-9 Tim-3

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Alopecia treatment using minimally manipulated human umbilical cord-derived mesenchymal stem cells:Three case reports and review of literature

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World Journal of Clinical Cases 2021年第15期9卷 3741-3751页

作者： Hyunjun Ahn Sang Yeon Lee Won Ju Jung Kye-Ho Lee bio Beauty&Health Company(bBHC)-stem Cell Treatment&Research Institute(STRI) Seoul 04420South Korea Department of Functional Genomics University of Science and Technology KRIBB SchoolDeajeon 34113South Korea 97.7 Beauty&Health(B&H)Clinics Seoul 04420South Korea

BACKGROUND Alopecia areata(AA)is a common autoimmune disease characterized by hair *** appears in extensive forms,such as progressive and diffusing hair loss(diffuse AA),a total loss of scalp hair(alopecia totalis),and complete loss of hair over the entire body(alopecia universalis).Recently,mesenchymal stem cells(MSCs)have been identified as a therapeutic alternative for autoimmune *** this reason,preclinical and case studies of AA and related diseases using MSCs have been *** SUMMARY Case 1:A 55-year-old woman suffered from AA in two areas of the *** was given 15 rounds of minimally manipulated umbilical cord-MSCs(MM-UC-MSCs)over 6 *** AA gradually improved 3 mo after the first *** patient was cured,and AA did not *** 2:A 30-year-old woman,with history of local steroid hormone injections,suffered from AA in one area on the *** was given two rounds of MM-UC-MSCs over 1 *** AA immediately improved after the first *** patient was cured,and AA did not *** 3:A 20-year-old woman,who was diagnosed with alopecia universalis at the age of 12,was given 14 rounds of MM-UC-MSCs over 12 *** hair began to grow about 3 mo after the first *** patient was cured,and alopecia universalis did not *** MM-UC-MSC transplantation potentially treats patients who suffer from AA and related diseases.

关键词： Alopecia areata umbilical cord-derived mesenchymal stem cells Allogenic Cell therapy Minimal manipulation Case report

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Treatment of acute ischemic stroke by minimally manipulated umbilical cord-derived mesenchymal stem cells transplantation:A case report

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World Journal of stem cells 2021年第8期13卷 1151-1159页

作者： Hyunjun Ahn Sang Yeon Lee Won Ju Jung Kye-Ho Lee bio Beauty&Health Company(bBHC)-stem Cell Treatment&Research Institute(STRI) Seoul 04420South Korea 97.7 Beauty&Health(B&H)Clinics Seoul 04420South Korea

BACKGROUND Stroke is one of the major causes of disability and death *** treatments for stroke exist,but existing treatment methods have limitations such as difficulty in the regeneration of damaged neuronal cells of the ***,mesenchymal stem cells(MSCs)have been studied as a therapeutic alternative for stroke,and various preclinical and case studies have been *** SUMMARY A 55-year-old man suffered an acute stroke,causing paralysis in the left upper and lower *** intravenously transplanted the minimally manipulated human umbilical cord-derived MSCs(MM-UC-MSCs)twice with an 8-d *** 65 wk after transplantation,the patient returned to his previous occupation as a veterinarian with no adverse *** MM-UC-MSCs transplantation potentially treats patients who suffer from acute ischemic stroke.

关键词： Acute ischemic stroke Behavioral disorder umbilical cord-derived mesenchymal stem cells Allogenic Cell therapy Minimal manipulation Case report

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Psoriasis treatment using minimally manipulated umbilical cordderived mesenchymal stem cells:A case report

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World Journal of Clinical Cases 2021年第23期9卷 6798-6803页

作者： Hyunjun Ahn Sang Yeon Lee Won-Ju Jung Jia Pi Kye-Ho Lee bio Beauty&Health Company(bBHC)-stem Cell Treatment and Research Institute(STRI) Seoul 04420South Korea Department of Functional Genomics University of Science and Technology KRIBB SchoolDeajeon 34113South Korea stem Cell Treatment 97.7 B&H ClinicSeoul 04420South Korea

BACKGROUND Psoriasis is a chronic autoimmune disease that usually manifests as a red scaly epidermis,induration,and hyperproliferation of basal *** 2%of the world’s population suffers from psoriasis but there are no clear therapeutics ***,mesenchymal stem cells(MSCs)have been regarded as a therapeutic alternative for autoimmune diseases,as they possess immunosuppressive effects without *** umbilical cord-derived MSCs effectively regulate immune cells and are characterized by low immunogenicity,which has many advantages in treating immune *** SUMMARY The patient was a 47-year-old male,diagnosed with psoriasis in *** had received various treatments for 25 years,but the psoriatic condition was not significantly *** was given three rounds of minimally manipulated umbilical cord-derived MSCs over 2 *** erythema gradually *** months after the 1st round,all erythema completely disappeared,and the psoriasis did not *** Minimally manipulated umbilical cord-derived MSC transplantation can potentially treat patients who suffer from psoriasis.

关键词： Psoriasis umbilical cord-derived mesenchymal stem cells Allogenic Cell therapy Minimal manipulation Case report

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Off-the-shelf mesenchymal stem cells from human umbilical cord tissue can significantly improve symptoms in COVID-19 patients: An analysis of evidential relations

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World Journal of stem cells 2020年第8期12卷 721-730页

作者： Phuc Van Pham Ngoc Bich Vu stem Cell Institute University of ScienceHo Chi Minh 08000Viet Nam Vietnam National University Ho Chi Minh 08000Viet Nam

Coronavirus disease-2019(COVID-19)has affected more than 200 countries *** disease has hugely affected healthcare systems as well as the economy to an extent never seen *** date,COVID-19 infection has led to about 165000 deaths in 150 *** present,there is no specific drug or efficient treatment for this *** this analysis based on evidential relationships of the biological characteristics of MSCs,especially umbilical cord(UC)-derived MSCs as well as the first clinical trial using MSCs for COVID-19 treatment,we discuss the use of UC-MSCs to improve the symptoms of COVID-19 in patients.

关键词： Coronavirus COVID-19 mesenchymal stem cells umbilical cord-derived mesenchymal stem cells

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