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Reference values of carotid intima-media thickness and arterial stiffness in Chinese adults based on ultrasound radio frequency signal: A nationwide, multicenter study

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中华医学杂志(英文版) 2024年第15期137卷 1802-1810页

作者： Xing Changyang Xie Xiujing Wu Yu Xu Lei Guan Xiangping Li Fan Zhan Xiaojun Yang Hengli Li Jinsong Zhou Qi Mu Yuming Zhou Qing Ding Yunchuan Wang Yingli Wang Xiangzhu Zheng Yu Sun Xiaofeng Li Hua Zhang Chaoxue Zhao Cheng Qiu Shaodong Yan Guozhen Yang Hong Mao Yinjuan Zhan Weiwei Ma Chunyan Gu Ying Chen Wu Xie Mingxing Jiang Tianan Yuan Lijun Department of ultrasound Medicine Tangdu Hospital Air Force Medical University Xi’an Shaanxi China Department of ultrasound Medicine The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang China Department of ultrasound Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China Department of ultrasound Xi’an Hospital of Traditional Chinese Medicine Xi’an Shaanxi China ultrasound Medical Diagnosis Center Shaanxi Provincial People’s Hospital Xi’an Shaanxi China Department of ultrasound Hospital of Northwestern Polytechnical University Xi’an Shaanxi China Department of ultrasound Xi’an No. Hospital The First Affiliated Hospital of Northwest University Xi’an Shaanxi China Department of ultrasound Diagnosis The Second Affiliated Hospital Xi’an Medical College Xi’an Shaanxi China Department of ultrasound Xi’an Gem Flower ChangQing Hospital Xi’an Shaanxi China Department of ultrasound The Second Affiliated Hospital of Xi’an Jiaotong University China Xi’an Shaanxi China Department of Echocardiography First Affiliated Hospital of Xinjiang Medical University Urumqi Xinjiang China Department of ultrasound Renmin Hospital of Wuhan University Wuhan Hubei China Department of ultrasound Yan’an Hospital The Affiliated Hospital of Kunming Medical University Kunming Yunnan China Department of ultrasound Yan’an University Xianyang Hospital Xianyang Shaanxi China Department of Function Examination Beijing University of Chinese Medicine Third Affiliated Hospital Beijing China Department of ultrasound Xi’an Central Hospital Xi’an Shaanxi China Cadre’s Wards ultrasound Department Diagnostic Ultrasound Center First Hospital of Jilin University Changchun Jilin China Department of Echocardiography Affiliated Hospital of Traditional Chinese Medicine of Xinjiang Medical University Urumqi Xinjiang China Department of ultrasound First Affiliated Hospital of Anhui Medical University Hefei

Background: Carotid intima-media thickness (IMT) and diameter, stiffness, and wave reflections, are independent and important clinical biomarkers and risk predictors for cardiovascular diseases. The purpose of the present study was to establish nationwide reference values of carotid properties for healthy Chinese adults and to explore potential clinical ***: A total of 3053 healthy Han Chinese adults (1922 women) aged 18-79 years were enrolled at 28 collaborating tertiary centers throughout China between April 2021 and July 2022. The real-time tracking of common carotid artery walls was achieved by the radio frequency (RF) ultrasound system. The IMT, diameter, compliance coefficient, β stiffness, local pulse wave velocity (PWV), local systolic blood pressure, augmented pressure (AP), and augmentation index (AIx) were then automatically measured and reported. Data were stratified by age groups and sex. The relationships between age and carotid property parameters were analyzed by Jonckheere-Terpstra test and simple linear regressions. The major clinical determinants of carotid properties were identified by Pearson’s correlation, multiple linear regression, and analyses of ***: All the parameters of carotid properties demonstrated significantly age-related trajectories. Women showed thinner IMT, smaller carotid diameter, larger AP, and AIx than men. The β stiffness and PWV were significantly higher in men than women before forties, but the differences reversed after that. The increase rate of carotid IMT (5.5 μm/year in women and 5.8 μm/year in men) and diameter (0.03 mm/year in both men and women) were similar between men and women. For the stiffness and wave reflections, women showed significantly larger age-related variations than men as demonstrated by steeper regression slopes (allP for age by sex interaction <0.05). The blood pressures, body mass index (BMI), and triglyceride levels were identified as major clinical determinants o

关键词： Intima-media thickness Arterial stiffness Reference values ultrasound radio frequency signal Wave reflections

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