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Prestin-Mediated frequency Selectivity Does not Cover ultrahigh Frequencies in Mice

Neuroscience Bulletin 2022年第7期38卷 769-784页

作者： Jie Li Shuang Liu Chenmeng Song Tong Zhu Zhikai Zhao Wenzhi Sun Yi Wang Lei Song Wei Xiong School of Life Sciences Tsinghua UniversityBeijing 100084China IDG/MeGovern Institute for Brain Research at Tsinghua University Tsinghua UniversityBeijing 100084China Chinese Institute for Brain Research Beijing 102206China School of Basic Medical Sciences Capital Medical UniversityBeijing 100069China Department of Otolaryngology Head and Neck SurgeryShanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Ear Institute Shanghai Jiao Tong University School of MedicineShanghai 200092China Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases Shanghai 20001lChina

In mammals,the piezoelectric protein,Prestin,endows the outer hair cells(OHCs)with electromotility(eM),which confers the capacity to change cellular length in response to alterations in membrane *** with basilarmembrane resonance and possible stereociliary motility,Prestin-based OHC eM lays the foundation for enhancing cochlear sensitivity and frequency ***,it remains debatable whether Prestin contributes to ultrahigh-frequency hearing due to the intrinsic nature of the cel's low-pass *** low-pass_property of mouse OHC eM is based on the finding that eM magnitude dissipates within the frequency bandwidth of human *** this study,we examined the role of Prestin in sensing broad-range frequencies(4-80 kHz)in mice that use ultrasonic hearing and vocalization(to>100 kHz)for social *** audiometric measurements in mice showed that ablation of Prestin did not abolish hearing at frequencies>40 *** associative behavior tests confirmed that Prestin-knockout mice can learn ultrahigh-frequency sound-coupled tasks,similar to control *** vivo cochlear Ca2+imaging experiments demonstrated that without Prestin,the OHCs still exhibit ultrahigh-frequency transduction,which in contrast,can be abolished by a universal cation channel blocker,*** vivo salicylate treatment disrupts hearing at frequenciesultrahigh-frequency *** pharmacogenetic manipulation,we showed that specific ablation of the OHCs largely abolished hearing at frequencies>40 *** findings demonstrate that cochlear OHCs are the target cells that support ultrahigh-frequency transduction,which does not require Prestin.

关键词： Prestin PIEZO2 ultrahigh-frequency hearing Electromotility Outer hair cells

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