检索结果-南通市图书馆

Experimental evolution and proximate mechanisms in biology

Synthetic and Systems Biotechnology 2017年第4期2卷 253-258页

作者： Xiao Yi BioTechnology Institute University of MinnesotaSt.PaulMN 55108USA

Biological functions e studied by molecular,systems and behavioral biology e are referred to as proximate mechanisms.Why and how they have emerged from the course of evolution are referred to as ultimate mechanisms.Despite the conceptual and technical schism between the disciplines that focus on each,studies from one side can benefit the other.Experimental evolution is an emerging field at the crossroads of functional and evolutionary biology.Herein microorganisms and mammalian cell lines evolve in well-controlled laboratory environments over multiple generations.Phenotypic changes arising from the process are then characterized in genetics and function to understand the evolutionary process.While providing empirical tests to evolutionary questions,such studies also offer opportunities of new insights into proximate mechanisms.Experimental evolution optimizes biological systems by means of adaptation;the adapted systems with their mutations present unique perturbed states of the systems that generate new and often unexpected output/performance.Hence,learning about these states not only adds to but also might deepen knowledge on the proximate processes.To demonstrate this point,five examples in experimental evolution are introduced,and their relevance to functional biology explicated.In some examples,from evolution experiments,updates were made to known proximate processes e gene regulation and cell polarization.In some examples,new contexts were found for known proximate processes e cell division and drug resistance of cancer.In one example,a new cellular mechanism was discovered.These cases identify ways the approach of experimental evolution can be used to ask questions in functional biology.

关键词： Experimental evolution Proximate mechanisms ultimate mechanisms Gene network Modules

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：