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Comparing the clinical application values of the Degree of ulcerative colitis Burden of Luminal Inflammation(DUBLIN)score and ulcerative colitis endoscopic index of severity(UCEIS)in patients with ulcerative colitis

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Gastroenterology Report 2021年第6期9卷 533-542页

作者： Xiao-Fei Zhang Peng Li Xue-Li Ding Hao Chen Shao-Jun Wang Sheng-Bo Jin Jing Guo Zi-Bin Tian Department of Gastroenterology The Affiliated Hospital of Qingdao UniversityQingdaoShandong266003P.R.China Department of Urology The Affiliated Hospital of Qingdao UniversityQingdaoShandong266003P.R.China

Background:The significance of endoscopic evaluation in the diagnosis and management of ulcerative colitis(UC)has been widely *** the years,scholars have established several endoscopic ***,we assessed the clinical application value of the Mayo endoscopic Subscore(Mayo ES),the Degree of ulcerative colitis Burden of Luminal Inflammation(DUBLIN)score,and the ulcerative colitis endoscopic index of severity(UCEIS)score in UC patients,by comparing their correlation with disease activity and their predictive potential for treatment response and clinical ***:UC patients hospitalized from September 2015 to September 2019 were retrospectively *** employed Spearman’s rank correlation coefficient to assess the linear association of the assessed endoscopic scores with the clinical *** receiver-operating characteristic curve was applied to evaluate the predictive capabilities of the endoscopic scores for treatment escalation and 1-year ***:A total of 178 patients were enrolled;most of them(82%)suffered moderate or severe *** them,48(27%)patients received treatment escalation and 59(33%)were readmitted within 1 *** DUBLIN and UCEIS scores demonstrated higher correlations with clinical parameters than the Mayo *** DUBLIN scores significantly differed between patients with mild,moderate,and severe colitis(all P<0.001).The UCEIS scores demonstrated the best predictabilities for treatment escalation and 1-year readmission with an area under the curve of 0.88 and 0.75,*** to the UCEIS and DUBLIN scores,the predictive capabilities of the Mayo ES for treatment escalation(both P<0.001)and 1-year readmission(P<0.001 and P紏0.002,respectively)were *** UCEIS scores exhibited a significant difference between the steroid-responsive group and the steroid-dependent or steroid-refractory group(both P<0.001),while no significant differences in the Mayo ES and DUBLIN scores were found amon

关键词： Mayo endoscopic Subscore Degree of ulcerative colitis Burden of Luminal Inflammation score ulcerative colitis endoscopic index of severity ulcerative colitis

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Cut-off value of ulcerative colitis endoscopic index of severity(UCEIS)score for predicting the need for pouch construction in ulcerative colitis:results of a multicenter study with long-term follow-up

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Gastroenterology Report 2021年第5期9卷 435-442,I0002页

作者： Weimin Xu Weijun Ou Jihong Fu Yubei Gu Long Cui Jie Zhong Peng Du Department of Colorectal Surgery Xinhua HospitalShanghai Jiaotong University School of MedicineShanghaiP.R.China Department of Gastroenterology Rui Jin HospitalShanghai Jiao Tong University School of MedicineShanghaiP.R.China

Background Total proctocolectomy with ileal pouch–anal anastomosis(IPAA)was the first choice for the surgical treatment of the ulcerative colitis(UC)*** data on the predictive value of the ulcerative colitis endoscopic index of severity(UCEIS)for the need for IPAA in UC patients is *** aimed to establish the UCEIS cut-off value to further analyse whether the UCEIS cut-off was suitable for predicting the need for IPAA in UC *** The clinical data of UC patients from June 1986 to March 2020 at our institute were retrospectively *** UCEIS scores recorded at the time of the first colonoscopy after hospitalization were used in the *** operating characteristic curve analysis was performed to determine the UCEIS cut-off value for predicting the need for *** A total of 283 UC patients were included in the study,with a median UCEIS of *** a median follow-up of 13 years,80 patients(28.3%)received surgery invention,among whom 75(93.8%)underwent IPAA surgery and 5(6.2%)received subtotal colectomy with permanent ostomy.A UCEIS cut-off of 6 had the most significant area under the curve of 0.769 for predicting the need for IPAA(P<0.001),with a sensitivity of 72.0%and specificity of 81.8%.UCEIS≥6 was an independent predictive factor for the need for IPAA(P<0.001)and malignant transformation(P=0.010).Patients with UCEIS≥6 had a significantly shorter IPAA-free survival time than those with UCEIS<6(P<0.001).Conclusions UCEIS≥6 may be a threshold value for decision-making for IPAA and should be recommended for UC patients for reducing the incidence of malignant transformation.

关键词： ulcerative colitis endoscopic index of severity ileal pouch-anal anastomosis ulcerative colitis

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Comparison of fecal calprotectin levels and endoscopic scores for predicting relapse in patients with ulcerative colitis in remission

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World Journal of Gastroenterology 2023年第47期29卷 6111-6121页

作者： Natsuki Ishida Tatsuhiro Ito Kenichi Takahashi Yusuke Asai Takahiro Miyazu Tomohiro Higuchi Satoshi Tamura Shinya Tani Mihoko Yamade Moriya Iwaizumi Yasushi Hamaya Satoshi Osawa Ken Sugimoto Department of endoscopic and Photodynamic Medicine Hamamatsu University of School of MedicineHamamatsu 431-3192Japan First Department of Medicine Hamamatsu University of School of MedicineHamamatsu 431-3192Japan Department of Laboratory Medicine Hamamatsu University of School of MedicineHamamatsu 431-3192Japan

BACKGROUND Although the usefulness of endoscopic scores,such as the Mayo endoscopic Subscore(MES),ulcerative colitis endoscopic index of severity(UCEIS),and ulcerative colitis Colonoscopic index of severity(UCCIS),and biomarkers such as fecal calprotectin(FC)for predicting relapse in ulcerative colitis(UC)has been reported,few studies have included endoscopic scores for evaluating the entire *** To compare the usefulness of FC value and MES,UCEIS,and UCCIS for predicting relapse in patients with UC in clinical *** In total,75 patients with UC in clinical and endoscopic remission who visited our institution between February 2019 and March 2022 were *** diagnosis of UC was confirmed based on the clinical presentation,endoscopic findings,and histology,according to the current established criteria for *** samples were collected the day before or after the colonoscopy for measurement of *** evaluations were performed using MES,UCEIS,and *** primary outcome measure of this study was the assessment of the association between relapse within 12 mo and MES,UCEIS,UCCIS,and *** secondary outcome was the comparison between endoscopic scores and biomarkers in en-rolled patients with UC with mucosal *** and UCCIS showed a significant correlation with UCEIS (r = 0.537, P < 0.001 and r = 0.957, P < 0.001, respectively).Receiver-operating characteristic analysis for predicting MES 0 showed that the area under the curve ofUCCIS was significantly higher than that of FC (P < 0.01). During the 1-year observation period, 18 (24%) patientsexperienced a relapse, and both the FC and UCCIS of the relapse group were significantly higher than that of theremission group. The cut-off values for predicting relapse were set at FC = 323 mg/kg and UCCIS = 10.2. The areaunder the curve of the receiver-operating characteristic analysis for predicting relapse did not show a significantdifference between FC and UCCIS. The accuracy of the

关键词： ulcerative colitis Mayo endoscopic Subscore ulcerative colitis endoscopic index of severity ulcerative colitis Colonoscopic index of severity Fecal calprotectin Relapse

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Clinical value of the Toronto inflammatory bowel disease global endoscopic reporting score in ulcerative colitis

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World Journal of Gastroenterology 2023年第48期29卷 6208-6221页

作者： Xin-Yue Liu Zi-Bin Tian Li-Jun Zhang Ai-Ling Liu Xiao-Fei Zhang Jun Wu Xue-Li Ding Department of Gastroenterology The Affiliated Hospital of Qingdao UniversityQingdao 266003Shandong ProvinceChina Department of Population and Quantitative Health Sciences(PQHS) School of MedicineCase Western Reserve UniversityClevelandOH 44106United States Department of Gastroenterology Qingdao HospitalUniversity of Health and Rehabilitation Sciences(Qingdao Municipal Hospital)Qingdao 266011Shandong ProvinceChina

BACKGROUND endoscopic evaluation in diagnosing and managing ulcerative colitis(UC)is becoming increasingly *** endoscopic scoring systems have been established,including the ulcerative colitis endoscopic index of severity(UCEIS)score and Mayo endoscopic Subscore(MES).Furthermore,the Toronto Inflammatory Bowel Disease Global endoscopic Reporting(TIGER)score for UC has recently been proposed;however,its clinical value remains *** To investigate the clinical value of the TIGER score in UC by comparing it with the UCEIS score and *** This retrospective study included 166 patients with UC who underwent total colonoscopy between January 2017 and March 2023 at the Affiliated Hospital of Qingdao University(Qingdao,China).We retrospectively analysed endoscopic scores,laboratory and clinical data,treatment,and readmissions within 1 ***’s rank correlation coefficient,receiver operating characteristic curve,and univariate and multivariable logistic regression analyses were performed using IBM SPSS Statistics for Windows,version 26.0(IBM Corp.,Armonk,NY,United States)and GraphPad Prism version 9.0.0 for Windows(GraphPad Software,Boston,Massachusetts,United States).RESULTS The TIGER score significantly correlated with the UCEIS score and MES(r=0.721,0.626,both Pseverity among mild,moderate,and severe UC[8(4-112.75)vs 210(109–219)vs 328(219–426),all P<0.001],and exhibited predictive value in diagnosing patients with severe UC[area under the curve(AUC)=0.897,P<0.001].Additionally,the TIGER(r=0.639,0,551,0.488,0.376,all P<0.001)and UCEIS scores(r=0.622,0,540,0.494,and 0.375,all P<0.001)showed stronger correlations with laboratory and clinical parameters,including C-reactive protein,erythrocyte sedimentation rate,length of hospitalisation,and hospitalisation costs,than MES(r=0.509,0,351,0.339,and 0.270,all P<0.001).The TIGER score showed the best predictability for patients'recent advanced

关键词： ulcerative colitis Toronto Inflammatory Bowel Disease Global endoscopic Reporting score ulcerative colitis endoscopic index of severity Mayo endoscopic Subscore Endoscopy severity

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Remission endpoints in ulcerative colitis: A systematic review

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World Journal of Meta-Analysis 2017年第4期5卷 85-102页

作者： Maki Jitsumura Rory Frederick Kokelaar Dean Anthony Harris Colorectal Department Singleton Hospital Abertawe Bro Morgannwg University Health Board

AIM To summarize the current consensus on the defnition of remission and the endpoints employed in clinical *** bibliogragraphic search was performed from 1946 to 2016 sing online databases （National Library of Medicine’s PubMed Central Medline, OVID SP MEDLINE, OVID EMBASE, the Cochrane Library and Conference Abstracts） with key words：（“ulcerative colitis”） AND （“ulcerative colitis endoscopic index of severity” OR “UCEIS”） AND （“remission”） as well as （“ulcerative colitis”） AND （“ulcerative colitis disease activity index”） OR “UCDAI” OR “UC disease activity index” OR “Sutherland index”） AND （“remission”）.RESULTSThe search returned 37 and 116 articles for the UCEIS and UCDAI respectively. For the UCEIS, 12 articles were cited in the final analysis of which 9 validation studies have been identified. Despite the UCEIS has been more extensively validated in all three aspects （validity, responsiveness and reliability）, it has been little employed to monitor disease in randomised clinical trials. For the UCDAI, 37 articles were consider-ed for the final analysis. Although the UCDAI is only partially validated, 29 randomised clinical trials were acknowledged to use the UCDAI to determine endpoints and disease remission, though no clear protocol was *** the UCEIS has been more widely validated than the UCDAI, it has not been refected in the moni-toring of disease activity in clinical trials. Conversely, the UCDAI has been used in numerous large clinical trials to defne their endpoints and disease remission, however, it is challenging to determine the best possible outcomes due to a lack of homogeneity of the clinical trial protocols. Before determining a gold standard index, international agreement on remission is urgently needed to advance patient care.

关键词： ulcerative colitis Remission ulcerative colitis endoscopic index of severity ulcerative disease activity index

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